Aerosol-generating system comprising a novel delivery enhancing compound source

Patent metadata

Field	Value
Publication number	US-10485261-B2
Application number	US-201515512599-A
Country	US
Kind code	B2
Filing date	Sep 25, 2015
Priority date	Sep 26, 2014
Publication date	Nov 26, 2019
Grant date	Nov 26, 2019

Abstract

An aerosol-generating system is provided, including a nicotine source; and a delivery enhancing compound source, which includes a reaction product of one or both of:
(i) an alpha-keto carboxylic acid and a compound of formula (I)

where R 1 is selected from alkyl, phenyl, or substituted phenyl, and
(ii) an alpha-hydroxy acid and a compound of formula (II)

where X is a halogen and R 2 is selected from H, alkyl, phenyl, or substituted phenyl.

First claim

The invention claimed is:

1. An aerosol-generating system, comprising:
a nicotine source; and
a delivery enhancing compound source,
wherein the delivery enhancing compound source comprises a reaction product of one or both of:
(i) an alpha-keto carboxylic acid and a compound of formula (I)

where R 1 is selected from alkyl, phenyl, or substituted phenyl; and
(ii) an alpha-hydroxy acid and a compound of formula (II)

where X is a halogen and R 2 is selected from H, alkyl, phenyl, or substituted phenyl.

2. The aerosol-generating system according to claim 1 , wherein the delivery enhancing compound source comprises the reaction product of one or both of:
(i) an alpha-keto carboxylic acid of formula (III) and a compound of formula (I)

where R 3 is selected from C 1-4 alkyl; and
(ii) an alpha-hydroxy acid of formula (IV) and a compound of formula (II)

where R 4 is selected from C 1-4 alkyl.

3. The aerosol-generating system according to claim 1 , wherein n is an integer from 1 to 4 inclusive and R 1 is selected from C 1-4 alkyl.

4. The aerosol-generating system according to claim 1 , wherein X is Br and R 2 is selected from H and C 1-4 alkyl.

5. The aerosol-generating system according to claim 1 , wherein the delivery enhancing compound comprises a reaction product of one or both of:
(i) pyruvic acid and the compound of formula (I); and
(ii) lactic acid and the compound of formula (II).

6. The aerosol-generating system according to claim 5 , wherein the delivery enhancing compound comprises one or both of:
(i) 2,4-dimethyl-1,3-dioxolane-2-carboxylic acid; and
(ii) 2-(allyloxy)propanoic acid.

7. The aerosol-generating system according to claim 1 , further comprising:
an aerosol-generating article comprising the nicotine source and the delivery enhancing compound source; and
an aerosol-generating device configured to receive the aerosol-generating article.

8. The aerosol-generating system according to claim 7 , wherein the aerosol-generating device comprises a heater configured to heat one or both of the nicotine source and the delivery enhancing compound source of the aerosol-generating article.

9. The aerosol-generating system according to claim 8 , wherein the heater comprises a single heater configured to heat both the nicotine source and the delivery enhancing compound source of the aerosol-generating article.

10. The aerosol-generating system according to claim 7 , wherein the aerosol-generating article further comprises a first compartment comprising the nicotine source and a second compartment comprising the delivery enhancing compound source.

11. The aerosol-generating system according to claim 10 , wherein one or both of the first compartment and the second compartment are sealed by one or more frangible barriers, and the aerosol-generating device further comprises one or more piercing members configured to rupture the one or more frangible barriers.

12. The aerosol-generating system according to claim 10 , wherein the aerosol-generating article further comprises a third compartment comprising an aerosol-modifying agent.

13. An aerosol-generating article for an aerosol-generating system, the aerosol-generating article comprising:
a nicotine source and a delivery enhancing compound source,
the aerosol-generating article being removably insertable into an aerosol-generating device,
wherein the delivery enhancing compound source comprises a reaction product of one or both of:
(i) an alpha-keto carboxylic acid and a compound of formula (I)

where R 1 is selected from alkyl, phenyl, or substituted phenyl; and
(ii) an alpha-hydroxy acid and a compound of formula (II)

where X is a halogen and R 2 is selected from H, alkyl, phenyl, or substituted phenyl.

14. A method of generating an aerosol comprising nicotine salt particles, comprising:
reacting nicotine with a reaction product of one or both of:
(i) an alpha-keto carboxylic acid and a compound of formula (I)

where R 1 is selected from alkyl, phenyl, or substituted phenyl; and
(ii) an alpha-hydroxy acid and a compound of formula (II)

where X is a halogen and R 2 is selected from H, alkyl, phenyl, or substituted phenyl.

15. An aerosol-generating system for generating an aerosol comprising nicotine salt particles, comprising:
a nicotine source; and
a delivery enhancing compound source comprising one or both of:
(i) 2,4-dimethyl-1,3-dioxolane-2-carboxylic acid; and
(ii) 2-(allyloxy)propanoic acid.

Assignees

• Philip Morris Products Sa

Inventors

• Schaller Jean-Pierre

Classifications

• B65B29/10

  Packaging two or more different substances isolated from one another in the package but capable of being mixed without opening the package, e.g. forming packages containing a resin and hardener isolated by a frangible partition · CPC title

• A24B15/16 Primary

  of tobacco substitutes · CPC title

• C07D317/32

  with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms · CPC title

• C07D401/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• A24B15/167 Primary

  in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes · CPC title