Cell separation filter material and filter obtained by layering same

Patent metadata

Field	Value
Publication number	US-10478537-B2
Application number	US-201415030130-A
Country	US
Kind code	B2
Filing date	Oct 7, 2014
Priority date	Oct 18, 2013
Publication date	Nov 19, 2019
Grant date	Nov 19, 2019

Abstract

An object of the present invention is to provide a novel filter material and a filter including the same. Specifically, the present invention aims to provide a filter material capable of filtering in a short period of time, without clogging of the filter, while maintaining high cell separation properties, and a filter including the same. More specifically, the present invention aims to provide a filter material in which fiber masses (flocs) are uniformly distributed, and a filter including the same. The present invention provides a novel filter material showing excellent cell separation properties and excellent flow-through properties regardless of design choices for filters known prior to the filing of the present application, and an efficient cell separation method using a novel filter on which the filter material is stacked.

First claim

The invention claimed is:

1. A filter comprising:
an inlet and an outlet for a liquid; and
at least two nonwoven fabrics stacked in a liquid flow direction,
wherein
a nonwoven fabric, of the at least two nonwoven fabrics, on an inlet side of the filter, and a nonwoven fabric, of the at least two nonwoven fabrics, on an outlet side of the filter have an average fiber diameter of from 0.3 to 5.0 μm,
a thickness of from 0.10 to 0.60 mm,
a basis weight of from 10 to 100 g/m 2 , and
an average floc size index of from 1.0 to 4.0.

2. The filter according to claim 1 , wherein the nonwoven fabric on an outlet side of the filter has a floc size index ratio of from 0.78 to 1.02.

3. The filter according to claim 1 , wherein the nonwoven fabric on an outlet side of the filter has an average floc size index corresponding to that determined for a thickness of from 0.30 mm of 1.0 to 3.0.

4. The filter according to claim 1 , wherein the nonwoven fabric on an outlet side of the filter has a floc size index ratio of from 0.84 to 1.02 that corresponds to an average floc size index determined for a thickness of 0.30 mm.

5. The filter according to claim 1 , further comprising:
a different type of a filter material which is different from the at least two nonwoven fabrics, wherein the different type of a filter material is positioned on an inlet side, an outlet side, or both, of the filter.

6. The filter according to claim 1 , wherein
the filter comprises a first filter material positioned on an outlet side of the filter and a second filter material positioned on an inlet side of the filter, and
an average fiber diameter of the second filter material is larger than an average fiber diameter of the first filter material.

7. The filter according to claim 1 , further comprising:
a pre-filter material configured to remove microscopic aggregates and positioned on an inlet side of the filter.

8. A filter system, comprising:
the filter according to claim 1 ;
a blood collection bag connected to an inlet side of the filter; and
at least one blood bag connected to an outlet side of the filter.

9. The filter according to claim 1 , wherein the filter comprises from 5 to 100 filter materials.

10. The filter according to claim 6 , wherein the average fiber diameter of the first filter material is from 0.3 to 5.0 μm, and the average fiber diameter of the second filter material is from 1.0 to 10.0 μm.

11. The filter material according to claim 1 , wherein the nonwoven fabric on an outlet side of the filter has the average fiber diameter of from 0.4 to 4.0 μm, the thickness of from 0.14 to 0.55 mm, and the average floc size index of from 2.3 to 3.4.

12. The filter material according to claim 1 , wherein at least one of the nonwoven fabrics has an average pore size of from 4.0 μm to 30.0 μm.

Assignees

• Kaneka Corp

Inventors

• Suzuki Ikuhiro
• Miyamoto Takayuki
• Shibata Takao

Classifications

• B01D2239/1216

  Pore size · CPC title

• A61M2202/0014

  removed from the body · CPC title

• A61M2205/7527

  liquophilic, hydrophilic · CPC title

• A61M2202/0028

  fluid entering a filter · CPC title

• B01D2239/1291

  Other parameters · CPC title