Combination of tolerogenic peptides and TFG-B for use in the induction and maintenance of oral tolerance in young mammals

Patent metadata

Field	Value
Publication number	US-10478472-B2
Application number	US-201615580180-A
Country	US
Kind code	B2
Filing date	Jun 10, 2016
Priority date	Jun 12, 2015
Publication date	Nov 19, 2019
Grant date	Nov 19, 2019

Abstract

This invention relates to the administration of a combination of TGF-β and one or more peptides comprising specific sequences of β-lacto-globulin. The peptides are hypoallergenic but retain the capability to induce tolerance to the native protein. The combination of TGF-β and one or more of these peptides has the therapeutic effect of inducing and maintaining oral tolerance towards newly introduced proteins, in particular, at the weaning period. The combination can modulate the infant and toddler immune response to allergens.

First claim

The invention claimed is:

1. A method for induction and maintenance of oral tolerance to β-lactoglobulin (BLG) and maintenance of oral tolerance to other food proteins that has been acquired via consumption of maternal mill in a young mammal during and after weaning period, the method comprising administering to the young mammal a composition comprising at least eight different peptides; each having a length from five to twelve amino adds that comprises a sequence selected from SEQ ID No. 1-8, and the composition further comprising transforming growth factor-beta (TGF-β), wherein each of SEQ ID NOs: 1-8 is present in the composition.

2. A method for primary prevention of allergic reactions to milk proteins and to electedly introduced dietary protein in a young mammal during and after weaning, the method comprising administering to the young mammal a composition comprising at least eight different peptides, each having a length from five to twelve amino adds that comprises a sequence selected from SEQ ID No. 1-8, and the composition further comprising TGF-β-β), wherein each of SEQ NOs: 1-8 is present in the composition.

3. The method according to claim 1 , wherein the young mammal is a human infant or toddler.

4. The method according to claim 1 , wherein the young mammal has been fed maternal milk from a mother who has been exposed to an ingredient selected from the group consisting of milk, egg, nut, peanut, shellfish, wheat, soy, and any other food protein during the feeding period.

5. The method according to claim 1 , wherein the young mammal is at risk of developing allergy.

6. The method according to claim 1 , wherein the young mammal is a companion animal.

7. The method according to claim 2 , wherein the young mammal is a human infant or toddler.

8. The method according to claim 2 , wherein the young mammal has been fed maternal milk from a mother who has been exposed to an ingredient selected from the group consisting of milk, egg, nut, peanut, shellfish, wheat, soy, and any other food protein during the feeding period.

9. The method according to claim 2 , wherein the young mammal is at risk of developing allergy.

10. The method according to claim 2 , wherein the young mammal is a companion animal.

Assignees

• Nestec Sa
• Nestle Sa

Inventors

• Nutten Sophie Helene
• De Groot Nanda
• Verhasselt Valerie Francoise

Classifications

• A23K50/60

  for weanlings · CPC title

• A23L33/17 Primary

  Amino acids, peptides or proteins · CPC title

• A23K20/147 Primary

  Polymeric derivatives, e.g. peptides or proteins · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L33/18

  Peptides; Protein hydrolysates · CPC title