Method for inhibiting ADAM proteases with cyclic peptides

Patent metadata

Field	Value
Publication number	US-10472393-B2
Application number	US-201615372732-A
Country	US
Kind code	B2
Filing date	Dec 8, 2016
Priority date	Oct 12, 2007
Publication date	Nov 12, 2019
Grant date	Nov 12, 2019

Abstract

The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also provided are cyclic peptides which inhibit binding to an integrin-binding loop of an ADAM protease, as well as associated pharmaceutical compositions, uses and methods of treatment.

First claim

The invention claimed is:

1. A method for inhibiting an ADAM protease, comprising contacting the ADAM protease with a cyclic peptide of formula I:

wherein X 0 , X 1 , X 2 and X 3 each independently represents an amino acid residue;
wherein each amino acid residue in the cyclic peptide is joined by a peptide bond;
wherein each X 0 may be the same or different;
wherein X 1 , X 2 , and X 3 are selected such that the cyclic peptide comprises one of the following amino acid sequences: KDM, ARQ, DSD, NAT, VRQ, and TDD;
and wherein n is 0 to 4;
or a pharmaceutically acceptable salt thereof.

2. The method according claim 1 , wherein the ADAM protease comprises ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19, ADAM28 or ADAM33.

Assignees

• Cancer Research Tech Ltd
• King S College London

Inventors

• Bartsch Joerg
• Koller Garrit

Classifications

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61K38/005

  Enzyme inhibitors (protease inhibitors A61K38/55) · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title