Modulators of indoleamine 2,3-dioxygenase

Patent metadata

Field	Value
Publication number	US-10472336-B2
Application number	US-201615759600-A
Country	US
Kind code	B2
Filing date	Sep 22, 2016
Priority date	Sep 24, 2015
Publication date	Nov 12, 2019
Grant date	Nov 12, 2019

Abstract

Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the progression of AIDS and general immunosuppression.

First claim

What is claimed is:

1. A compound having the structure of Formula I:

or a pharmaceutically acceptable salt thereof, wherein:

X is
W is CR 4 ;
Y is CR 5 ;
V is CR 6 ;
R 1 is selected from the group consisting of —CO 2 H, tetrazol-5-yl, —NHSO 2 R 13 , and —CONHSO 2 R 14 ;
R 2 is selected from the group consisting of —H, —OH, —Cl, —F, and —OCH 3 ;
R 3 is —H;
R 4 is selected from the group consisting of —H and —F;
R 5 is selected from the group consisting of —H and —F;
R 6 is selected from the group consisting of —H, —F, and —Cl;
R 7 and P 8 are independently selected from the group consisting of the following structures

R 10 and R 11 are independently selected from the group consisting of —H, —CH 3 , and —CHF 3 ;

R 12 is selected from the group consisting of the following structures:

R 13 is —CH 3 ;
R 14 is selected from the group consisting of —CH 3 , —CF 3 , and -cC 3 H 5 .

2. The compound or salt of claim 1 , wherein R 1 is selected from —CO 2 H or tetrazol-5-yl.

3. The compound or salt of claim 1 , wherein R 2 is —H.

4. The compound or salt of claim 1 , wherein R 10 is —H.

5. The compound or salt of claim 1 , wherein R 11 is —CH 3 .

6. The compound or salt of claim 1 , wherein R 11 is —CF 3 .

7. The compound or salt of claim 1 , wherein

8. The compound or salt of claim 1 , wherein

9. The compound or salt of claim 1 , wherein

10. The compound or salt of claim 1 , wherein R 12

11. The compound or salt of claim 1 , wherein R 12 is

Assignees

• Glaxosmithkline Ip No 2 Ltd
• Glaxosmithkline Ip Dev Ltd

Inventors

• Chong Pek Yoke
• De La Rosa Martha Alicia
• Dickson Hamilton D
• Kazmierski Wieslaw Mieczyslaw
• Samano Vicente
• Tai Vincent Wing-Fai

Classifications

• C07D253/06

  1,2,4-Triazines · CPC title

• A61P37/02

  Immunomodulators · CPC title

• A61P31/18

  for HIV · CPC title

• C07D285/00

  Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00 · CPC title

• C07D307/66

  Nitrogen atoms · CPC title