Dispensing assembly

Patent metadata

Field	Value
Publication number	US-10466264-B2
Application number	US-201414530863-A
Country	US
Kind code	B2
Filing date	Nov 3, 2014
Priority date	May 8, 2012
Publication date	Nov 5, 2019
Grant date	Nov 5, 2019

Abstract

A dispensing assembly comprising a cartridge holder is presented. The cartridge holder can receive a cartridge for dispensing a fluid. The cartridge can comprise a reservoir for receiving the fluid. The reservoir can comprise an outlet. The reservoir can have an adjustable volume for forcing the fluid through the outlet. The cartridge can further comprise a nozzle for dispensing the fluid. The nozzle can be connected to the outlet. The dispensing assembly can further comprise an actuator for actuating the adjustable volume. The dispensing assembly can further comprise an impulse generator for imparting an impulse to the nozzle. The impulse generator can comprise an actor for contacting the nozzle. The dispenser assembly can further comprise a controller for controlling the actor and the impulse generator.

First claim

We claim:

1. A dispensing assembly, the dispensing assembly comprising:
a cartridge holder, wherein the cartridge holder receives a cartridge for dispensing a fluid, wherein the cartridge comprises a reservoir for receiving the fluid, wherein the reservoir comprises an outlet, wherein the reservoir has an adjustable volume for forcing the fluid through the outlet, wherein the cartridge further comprises a nozzle having an orifice for dispensing the fluid, wherein the nozzle is connected to the outlet;
an actuator for actuating the adjustable volume;
an impulse generator for imparting an impulse to the nozzle, wherein the impulse generator comprises an actor for contacting the nozzle and wherein the actor is in contact with the nozzle;
a meniscus detector for detecting a meniscus of the fluid, wherein the meniscus detector is located between the orifice and the actor and wherein the meniscus detector is configured to detect the meniscus in the nozzle; and
a controller programmed to control the actuator to force a predetermined volume of fluid through the outlet into the nozzle, to control the actuator to force fluid through the outlet, to detect the meniscus using the meniscus detector, and to control the actuator to halt the forcing of fluid through the outlet when the meniscus is in a predetermined location, wherein the controller is further programmed to control the impulse generator to impart an impulse to the nozzle after the predetermined volume of fluid is forced through the outlet and/or control the impulse generator to impart an impulse to the nozzle during the forcing of the predetermined volume fluid through the outlet.

2. The dispensing assembly according to claim 1 , wherein the meniscus detector is any one of the following: a capacitive sensor, an optical sensor, or a camera.

3. The dispensing assembly according to claim 1 , wherein the controller is programmed to control the actuator to withdraw a second predetermined volume of fluid through the outlet from the nozzle after controlling the impulse generator to impart the impulse.

4. The dispensing assembly according to claim 1 , wherein the nozzle is formed from a plastic.

5. The dispensing assembly according to claim 1 , wherein the nozzle dispenses the fluid in a first direction, wherein the actor contacts the nozzle with motion in a second direction, and wherein the first direction is transverse to the second direction.

6. The dispensing assembly according to claim 1 , wherein the dispensing assembly is a micro-fluidic dispensing assembly.

7. The dispensing assembly according to claim 1 , further comprises,
a valve for sealing the nozzle at a sealing location.

8. The dispensing assembly according to claim 7 , wherein withdrawing a second predetermined volume of fluid causes a meniscus of the fluid within nozzle to withdraw to a withdrawal location, and wherein the sealing location is between the withdrawal location and the orifice.

9. The dispensing assembly according to claim 1 , wherein the dispensing assembly comprises the cartridge.

10. The dispensing assembly according to claim 1 , wherein the fluid comprises any one of the following: a reagent, a blood grouping reagent, a solvent, a diluent, a catalyst, an antibody, an enzyme, a recombinant protein, a virus isolate, a virus, a biological reagent, a protein, a salt, a detergent, a nucleic acid, an acid, a base, a dispersion, latex particles, nano particles, magnetic particles, stem cells, cells, a biological structure, a microorganism, and combinations thereof.

11. The dispensing assembly according to claim 1 , wherein the cartridge comprises a syringe.

12. An automatic analyzer for analyzing a biological sample comprising a dispensing assembly according to claim 1 .

13. The dispensing assembly according to claim 1 , wherein the meniscus detector is a capacitive detector configured to surround at least a portion of the nozzle.

Assignees

• Roche Diagnostics Operations Inc

Inventors

• Bammesberger Stefan Borja
• Ernst Andreas
• Koltay Peter
• Losleben Nadine
• Tanguy Laurent

Classifications

• B05C5/0291

  the material being discharged on the work through discrete orifices as discrete droplets, beads or strips that coalesce on the work or are spread on the work so as to form a continuous coating · CPC title

• B05C5/0225

  characterised by flow controlling means, e.g. valves, located proximate the outlet (B05C5/0258, B05C5/0275 take precedence; supply valves upstream the coating head B05C11/1036) · CPC title

• B05B1/02

  designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, {or having an outlet of particular shape}(B05B1/26, B05B1/28, B05B1/34 take precedence) · CPC title

• B01L2200/143

  Quality control, feedback systems · CPC title

• B05B17/06

  using ultrasonic {or other kinds of} vibrations · CPC title