System and method for providing stable fluid flow

Patent metadata

Field	Value
Publication number	US-10466155-B2
Application number	US-201615373722-A
Country	US
Kind code	B2
Filing date	Dec 9, 2016
Priority date	Dec 30, 2015
Publication date	Nov 5, 2019
Grant date	Nov 5, 2019

Abstract

An embodiment of a system with a minute measure of pulsatility in a flow of a fluid is described that comprises a first pump configured to flow the fluid to a junction at a first flow rate that comprises a measure of pulsatility; and a second pump configured to flow a portion of the fluid from the junction at a second flow rate that is less than the first flow rate to produce a flow of the fluid at a third flow rate from the junction with a minute measure of pulsatility.

First claim

What is claimed is:

1. A system with a minute measure of pulsatility in a flow of a fluid, comprising:
a first pump configured to flow the fluid from a first junction to a second junction at a first flow rate that comprises a measure of pulsatility; and
a second pump configured to flow a portion of the fluid from the second junction to the first junction at a second flow rate that is less than the first flow rate to produce a forward flow of the fluid at a third flow rate from the second junction with a minute measure of pulsatility,
wherein the first pump, first junction, second junction, and second pump define a fluidic circuit wherein the fluid is flowed at the first flow rate in a first fluid pathway between the first junction and the second junction and wherein the fluid is flowed at the second flow rate in a second fluid pathway between the second junction and the first junction.

2. The system of claim 1 wherein the second flow rate is slower than the first flow rate.

3. The system of claim 1 wherein the first pump comprises a gear pump.

4. The system of claim 3 wherein the first pump comprises small teeth.

5. The system of claim 3 wherein the first pump operates at 1000RPM.

6. The system of claim 3 wherein the second pump comprises a gear pump.

7. The system of claim 5 the first pump comprises small teeth.

8. The system of claim 3 wherein the second pump operates at 990RPM.

9. The system of claim 1 wherein the first flow rate and the second flow rate are adjustable.

10. The system of claim 1 wherein the fluid flowing at the third flow rate enters a detection region.

11. The system of claim 10 wherein the detection region comprises a flow cell.

12. The system of claim 1 wherein a sample fluid is introduced to the fluid flowing at the third flow rate.

13. The system of claim 12 wherein the sample fluid and the fluid flowing at the third flow rate combine and become a single flow, wherein the sample fluid forms a core diameter portion of the single flow and the fluid flowing at the third flow rate comprises a sheath portion of the single flow.

14. The system of claim 13 wherein the single flow flows at a fourth flow rate.

15. The system of claim 14 wherein a third pump produces the fourth flow rate that is greater than the third flow rate, wherein the third pump draws the sample fluid into the fluid flowing at the third flow rate.

16. A method for providing a fluid flow with a minute measure of pulsatility, comprising:
while flowing a fluid in a first fluid pathway from a first junction to a second junction at a first flow rate that comprises a measure of pulsatility,
flowing a portion of the fluid in a second fluid pathway from the second junction to the first junction at a second flow rate that is less than the first flow rate to produce a forward flow at a third flow rate of the fluid from the second junction with a minute measure of pulsatility.

17. The method of claim 16 wherein the fluid flowing at the third flow rate enters a detection region.

18. The method of claim 16 wherein a sample fluid is introduced to the fluid flowing at the third flow rate.

19. The method of claim 18 , wherein the sample fluid and the fluid flowing at the third flow rate combine and become a single flow, wherein the sample fluid forms a core diameter portion of the single flow and the fluid flowing at the third flow rate comprises a sheath portion of the single flow.

20. The method of claim 19 wherein the single flow flows at a fourth flow rate.

21. The system of claim 1 , wherein the first pump is disposed in the first fluid pathway between the first junction and the second junction.

22. The system of claim 1 , wherein second pump is disposed in the second fluid pathway between the second junction and the first junction.

23. The method of claim 16 , wherein the first pump is disposed in the first fluid pathway between the first junction and the second junction.

24. The method of claim 16 , wherein second pump is disposed in the second fluid pathway between the second junction and the first junction.

Assignees

• Life Technologies Corp

Inventors

• Ward Michael
• Malkin Jason

Classifications

• F04C2270/90

  Remote control, e.g. wireless, via LAN, by radio, or by a wired connection from a central computer · CPC title

• F04C2270/44

  Conditions at the outlet of a pump or machine · CPC title

• F04C2270/215

  Controlled or regulated · CPC title

• F04C2270/205

  Controlled or regulated · CPC title

• F04C2270/185

  Controlled or regulated · CPC title