Ultraclean autosampler with syringe delivery for mass spectrometry

Patent metadata

Field	Value
Publication number	US-10465853-B2
Application number	US-201715620092-A
Country	US
Kind code	B2
Filing date	Jun 12, 2017
Priority date	Aug 19, 2014
Publication date	Nov 5, 2019
Grant date	Nov 5, 2019

Abstract

A system can include a valve assembly including a first valve and a second valve in fluid communication with the first valve. The valve assembly can be configured to deliver one or more of a sample, a chemical (e.g., an acid, a base, an organic chemical, etc.), and a standard via flow of a working fluid facilitated by one or more syringe pumps. Further, the one or more of the sample, the chemical, and the standard can maintain a physical separation from the one or more syringe pumps during delivery of the one or more of the sample, the chemical, and the standard.

First claim

What is claimed is:

1. A system comprising:
a first valve having at least three ports, the first valve switchable between a first position and a second position;
a second valve in fluid communication with the first valve, the second valve having at least four ports, the at least four ports including a mixing port, the second valve switchable between a first position and a second position;
a sample loop coupled between a first port of the first valve and a first port of the second valve;
a standard loop coupled between a second port of the first valve and a second port of the second valve;
a chemical loop coupled between a third port of the first valve and a third port of the second valve;
a plurality of syringe pumps including at least a first syringe pump, a second syringe pump, and a third syringe pump,
wherein the mixing port is in fluid communication with each of the sample loop, the standard loop, and the chemical loop when the second valve is in the second position to mix a fluid from at least two of the sample loop, the standard loop, and the chemical loop, wherein the mixing port is not in fluid communication with the sample loop, the standard loop, or the chemical loop when the second valve is in the first position, and
wherein the sample loop is in fluid communication with the first syringe pump of the plurality of syringe pumps when the second valve is in the second position, the standard loop is in fluid communication with the second syringe pump of the plurality of syringe pumps when the second valve is in the second position, the chemical loop is in fluid communication with the third syringe pump of the plurality of syringe pumps when the second valve is in the second position, and wherein each of the first syringe pump, the second syringe pump, and the third syringe pump is in fluid communication with a source of a working solution when the second valve is in the first position and in fluid communication with the second valve when the second valve is in the second position.

2. The system as recited in claim 1 , wherein the mixing port is in fluid communication with an inductively coupled plasma mass spectrometer (ICP-MS).

3. The system as recited in claim 1 , wherein the second valve includes a port positioned to receive a high purity diluent, the port in fluid communication with the mixing port.

4. The system as recited in claim 1 , wherein at least one of the sample loop, the standard loop, or the chemical loop includes a coiled fluid line.

5. The system as recited in claim 1 , wherein the mixing port is in fluid communication with a fourth syringe pump of the plurality of syringe pumps when the second valve is in the second operating position.

6. The system as recited in claim 5 , further comprising a fluid cleanup column coupled between the fourth syringe pump and the second valve.

7. The system as recited in claim 6 , further comprising a second cleanup column coupled between the first syringe pump and the first valve, a third cleanup column coupled between the second syringe pump and the first valve, and a fourth cleanup column coupled between the third syringe pump and the first valve.

8. The system as recited in claim 1 , further comprising one or more of:
a first cleanup column coupled between the first syringe pump and the first valve;
a second cleanup column coupled between the second syringe pump and the first valve; and a third cleanup column coupled between the third syringe pump and the first valve.

9. The system as recited in claim 8 , wherein one or more of the first cleanup column, the second cleanup column, and the third cleanup column includes an ion exchange resin.

Assignees

• Elemental Scientific Inc

Inventors

• Wiederin Daniel R
• Schultz Austin

Classifications

• H01J49/105

  using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP] · CPC title

• B01D15/361 Primary

  Ion-exchange · CPC title

• F15D1/06

  by influencing the boundary layer · CPC title

• F17D3/01 Primary

  for controlling, signalling, or supervising the conveyance of a product · CPC title

• G01N27/64

  using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber · CPC title