Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins and applications thereof
US-2018085436-A1 · Mar 29, 2018 · US
Oligosaccharide-protein conjugates
US10464962B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10464962-B2 |
| Application number | US-201615288486-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 7, 2016 |
| Priority date | Dec 16, 2008 |
| Publication date | Nov 5, 2019 |
| Grant date | Nov 5, 2019 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound having the structure: 2. A compound having the structure: wherein R 1 is a protecting group or a saccharide, wherein R 2 is hydrogen or methyl, and wherein R 3 is hydrogen or an allyl group. 3. The compound of claim 2 , wherein the compound is: 4. The compound of claim 2 , wherein the compound is: 5. The compound of claim 2 , wherein the compound is: 6. A compound selected from the group consisting of:
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Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title
- C07H15/04Primary
attached to an oxygen atom of the saccharide radical · CPC title
the organic macromolecular compound being a polysaccharide or a derivative thereof · CPC title
- A61K38/46Primary
Hydrolases (3) · CPC title
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- What does patent US10464962B2 cover?
- Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
- Who is the assignee on this patent?
- Genzyme Corp
- What technology area does this patent fall under?
- Primary CPC classification C07H15/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).