Nicotine salts, co-crystals, and salt co-crystal complexes
US-2018051002-A1 · Feb 22, 2018 · US
Nicotine salts, co-crystals, and salt co-crystal complexes
US10464917B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10464917-B2 |
| Application number | US-201815886496-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 1, 2018 |
| Priority date | May 27, 2014 |
| Publication date | Nov 5, 2019 |
| Grant date | Nov 5, 2019 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with orotic acid are described. The invention further provides methods of preparation and characterization of such nicotine salts. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.
First claim
Opening claim text (preview).
What is claimed: 1. A mono-orotic acid salt of nicotine and orotic acid, characterized by an X-ray powder diffraction pattern having peaks at one or more of the following 2-theta diffraction angles: 9.1, 14.7, 15.4, 17.3, 25.0, 25.4, and 27.0. 2. The salt of claim 1 , wherein at least about 50% of the salt is in crystalline form. 3. A method of preparing the salt of nicotine and orotic acid of claim 1 , comprising combining nicotine and orotic acid to form a solid and isolating the solid. 4. The method of claim 3 , wherein the combining comprises grinding the nicotine and orotic acid or comprises mixing the nicotine and orotic acid in neat nicotine or in a solvent selected from the group consisting of water, MEK, IPA, ethyl acetate and mixtures thereof. 5. The salt of claim 1 , wherein at least about 80% of the salt is in crystalline form. 6. The salt of claim 1 , wherein at least about 90% of the salt is in crystalline form.
Assignees
Inventors
Classifications
Two oxygen atoms · CPC title
battery-operated · CPC title
Fumaric acid · CPC title
Nicotine · CPC title
Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals · CPC title
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- What does patent US10464917B2 cover?
- The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with orotic acid are described. The invention further provides methods of preparation and characterization of such nicotine salts. In addition, tobacco products, including smoking articles, smokeless tobacco products, and …
- Who is the assignee on this patent?
- Reynolds Tobacco Co R
- What technology area does this patent fall under?
- Primary CPC classification C07D401/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).