Antimicrobial guanidinium and thiouronium functionalized polymers
US-2016338356-A1 · Nov 24, 2016 · US
Macromolecular chemotherapeutics
US10463746B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10463746-B2 |
| Application number | US-201715807602-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 9, 2017 |
| Priority date | Nov 9, 2017 |
| Publication date | Nov 5, 2019 |
| Grant date | Nov 5, 2019 |
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Abstract
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Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.
First claim
Opening claim text (preview).
What is claimed is: 1. A macromolecular chemotherapeutic, comprising: a block copolymer comprising: a water-soluble block comprising polyethylene oxide, a cationic block comprising subunits of formula (C-4): wherein and R5 is: a linker comprising an acetal, wherein the linker is connected to the water-soluble bock and the charged block. 2. The macromolecular chemotherapeutic of claim 1 , wherein the linker is a cleavable linker. 3. The macromolecular chemotherapeutic of claim 2 , wherein the polyethylene oxide has an average molecular weight of 2000 to 20,000 daltons. 4. The macromolecular chemotherapeutic of claim 1 , wherein the block copolymer is self-immolative at a pH less than or equal to 6.5. 5. A pharmaceutical composition, comprising: a block copolymer comprising: a water-soluble block comprising polyethylene oxide, a cationic block comprising subunits of formula (C-4): wherein and R5 is: a linker comprising an acetal, wherein the linker is connected to the water-soluble bock and the charged block; and a solvent. 6. The pharmaceutical composition according to claim 5 further comprising a plurality of micelles. 7. The pharmaceutical composition according to claim 6 , wherein the micelles are mixed micelles. 8. The pharmaceutical composition according to claim 6 , wherein the micelles have an average diameter of 20 to 200 nanometers. 9. The pharmaceutical composition of claim 5 , wherein the linker is a cleavable linker. 10. The pharmaceutical composition according to claim 5 , wherein the polyethylene oxide has an average molecular weight of 2000 to 20,000 daltons.
Assignees
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Classifications
containing acetal or formal groups · CPC title
heterocyclic · CPC title
Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule · CPC title
containing carboxyl groups, or halides, or esters thereof · CPC title
containing polyether sequences · CPC title
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Frequently asked questions
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- What does patent US10463746B2 cover?
- Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.
- Who is the assignee on this patent?
- IBM, Agency Science Tech & Res
- What technology area does this patent fall under?
- Primary CPC classification A61K47/60. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).