Method and apparatus for adjusting corneal curvature through digital corneal crosslinking

Patent metadata

Field	Value
Publication number	US-10463735-B2
Application number	US-201615352467-A
Country	US
Kind code	B2
Filing date	Nov 15, 2016
Priority date	Aug 17, 2016
Publication date	Nov 5, 2019
Grant date	Nov 5, 2019

Abstract

The present disclosure concerns a digital corneal crosslinking technology for adjusting the corneal curvature, comprising the following steps: administering in drops a composition comprising a photoinitiator compound to the corneal stromal of the subject, locally irradiating the corneal by utilizing digital micromirror device controlled by computer. The corneal curvature can be adjusted totally or locally. The invention also discloses an apparatus for the digital corneal crosslinking. The method and apparatus is minimum invasive and can be used to accurately and efficiently adjust the corneal curvature.

First claim

The invention claimed is:

1. A method of digitally adjusting a corneal curvature of an eye in a subject, the method comprising the steps of: dropping a composition comprising a photoinitiator compound to the corneal stromal of the subject, locally irradiating the corneal by utilizing a digital micromirror device controlled by graphic software in a computer, whereby the corneal curvature is altered,
wherein local irradiation area and time on the corneal is determined through biomechanical simulation by establishing a dynamic model of crosslinking traction between the photoinitiator and the corneal stromal under irradiation and determining a relation between the local irradiation time and crosslinking density,
wherein a corneal biomechanics analyzer is used to obtain biomechanical data including corneal thickness, intraocular pressure to set up a mechanical model,
wherein finite element analysis is applied to obtain an internal stress distribution for a certain curvature change and obtain a crosslinking density distribution,
wherein the digital micromirror device is used to adjust the local irradiation area and time,
wherein the method utilizes an eye tracking/positioning device and a corneal topography acquisition device, and wherein the eye tracker is a device for measuring eye ball movement, transferring information to the computer; the corneal topography acquisition device sends the corneal curvature and thickness in real-time to the computer; and the computer adjusts the irradiation area and irradiation time according to the feedback from the eye tracker and the corneal topography acquisition device.

2. The method of claim 1 , wherein the photoinitiator is selected from riboflavin, riboflavin derivatives, eosin Y, eosin Y derivatives, acriflavine, quinidine, methylene blue, or erythrosine.

3. The method of claim 2 , wherein when the photoinitiator is riboflavin or riboflavin derivatives, wavelength of light is 320-400 nm; and wherein when the photoinitiator is eosin Y, eosin Y derivatives, acriflavine, quinidine, methylene blue and erythrosine, the wavelength is 460-668 nm.

4. The method of claim 1 , wherein the amount of the photoinitiator ranges from 0.01 to 0.5% by weight.

5. The method of claim 1 , wherein the composition additionally contains an assisting penetrating agent.

6. The method of claim 5 , wherein the penetrating agent is selected from polysorbate 80, trometamol, azone, benzoyl hydroxylamine chloride, cetylpyridinium chloride, lauric acid, cetyl trimethyl ammonium chloride, polyoxyethylene, sodium salicylate, taurocholic acid, or a combination thereof; and the amount of which ranges from 0.01 to 5% by weight.

7. The method of claim 1 , wherein the composition contains dextran; and the amount of which ranges from 0.01 to 20% by weight.

8. The method of claim 1 , wherein the light irradiation time ranges from 0.1 to 5 min; the power of the light ranges from 0.1 to 5 mW/cm 2 .

9. The method of claim 2 , wherein the amount of the photoinitiator ranges from 0.01 to 0.5% by weight.

10. A method of digitally adjusting a corneal curvature of an eye in a subject, the method comprising the steps of: dropping a composition comprising a photoinitiator compound to the corneal stromal of the subject, locally irradiating the corneal by utilizing a digital micromirror device controlled by graphic software in a computer, whereby the corneal curvature is altered,
wherein local irradiation area and time on the corneal is determined through biomechanical simulation by establishing a dynamic model of crosslinking traction between the photoinitiator and the corneal stromal under irradiation and determining a relation between the local irradiation time and crosslinking density,
wherein a corneal biomechanics analyzer is used to obtain biomechanical data including corneal thickness, intraocular pressure to set up a mechanical model,
wherein finite element analysis is applied to obtain an internal stress distribution for a certain curvature change and obtain a crosslinking density distribution,

wherein the digital micromirror device is used to adjust the local irradiation area and time,
wherein the method utilizes an eye tracking/positioning device and a corneal topography acquisition device, and wherein the eye tracker is a device for measuring eye ball movement, transferring information to the computer; the corneal topography acquisition device sends the corneal curvature and thickness in real-time to the computer; and the computer adjusts the irradiation area and irradiation time according to the feedback from the eye tracker and the corneal topography acquisition device,
wherein when the photoinitiator is riboflavin or riboflavin derivatives, wavelength of light is 320-400 nm; and wherein when the photoinitiator is eosin Y, eosin Y derivatives, acriflavine, quinidine, methylene blue and erythrosine, the wavelength is 460-668 nm,
wherein the composition additionally contains an assisting penetrating agent,
wherein the penetrating agent is selected from polysorbate 80, trometamol, azone, benzoyl hydroxylamine chloride, cetylpyridinium chloride, lauric acid, cetyl trimethyl ammonium chloride, polyoxyethylene, sodium salicylate, taurocholic acid, or a combination thereof; and the amount of which ranges from 0.01 to 5% by weight.

Assignees

• Univ Zhejiang

Inventors

• Xie Tao
• Wu Jingjun
• Zhao Qian
• Huang Limei

Classifications

• A61K41/0057 Primary

  Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent · CPC title

• A61F9/008

  using laser · CPC title

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title

• A61F9/0008

  Introducing ophthalmic products into the ocular cavity or retaining products therein (putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00) · CPC title

• A61F2009/00872

  Cornea · CPC title