Artificial blood vessel, method for producing artificial blood vessel, and method for producing porous tissue regeneration substrate

Patent metadata

Field	Value
Publication number	US-10463469-B2
Application number	US-201615747815-A
Country	US
Kind code	B2
Filing date	Aug 2, 2016
Priority date	Aug 6, 2015
Publication date	Nov 5, 2019
Grant date	Nov 5, 2019

Abstract

The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.

First claim

The invention claimed is:

1. A method for producing a porous, tubular artificial blood vessel containing a bioabsorbable material, the method comprising:
a dissolving step of preparing a uniform solution containing a bioabsorbable polymer dissolved therein using a bioabsorbable polymer, a solvent 1 having a relatively low solvency for the bioabsorbable polymer, a solvent 2 having a relatively high solvency for the bioabsorbable polymer and being incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2;
an applying step of applying the uniform solution to a surface of a rod-shaped body;
a precipitating step of cooling the uniform solution on the surface of the rod-shaped body to precipitate a tubular porous body containing the bioabsorbable polymer around the rod-shaped body; and
a freeze-drying step of freeze-drying the tubular porous body to give a tubular artificial blood vessel.

2. The method for producing an artificial blood vessel according to claim 1 ,
wherein the rod-shaped body contains a metal.

3. The method for producing an artificial blood vessel according to claim 1 , further comprising the step of discharging ultrafine fibers containing a bioabsorbable material on the surface of the tubular porous body by electrospinning to form an ultrafine fiber nonwoven fabric layer on the tubular porous body.

4. A method for producing a porous tissue regeneration substrate containing a bioabsorbable polymer, the method comprising:
a dissolving step of preparing a uniform solution containing a bioabsorbable polymer dissolved therein using a bioabsorbable polymer, a solvent 1 having a relatively low solvency for the bioabsorbable polymer, a solvent 2 having a relatively high solvency for the bioabsorbable polymer and being incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2;
a precipitating step of cooling the uniform solution to precipitate a porous body containing the bioabsorbable polymer; and
a freeze-drying step of freeze-drying the porous body containing the bioabsorbable polymer to give a porous tissue regeneration substrate.

5. The method for producing a porous tissue regeneration substrate according to claim 4 ,
wherein two or more common solvents 3 are used, and a pore size of the resulting porous body is controlled by adjusting a mixing ratio between the two or more common solvents 3.

Assignees

• Gunze Kk

Inventors

• Nakayama Hidetaka
• Sawai Kosuke
• Shinoka Toshiharu
• Tara Shuhei
• Kurobe Hirotsugu

Classifications

• A61L27/507

  for artificial blood vessels (apparatus for applying cells on a blood vessel prosthesis A61F2/062) · CPC title

• C08J2201/0522

  the liquid phase being organic · CPC title

• C08J2205/024

  Organogel, i.e. a gel containing an organic composition · CPC title

• C08J2207/10

  Medical applications, e.g. biocompatible scaffolds · CPC title

• C08J2205/022

  Hydrogel, i.e. a gel containing an aqueous composition · CPC title