Bio-sensing apparatus

Patent metadata

Field	Value
Publication number	US-10460188-B2
Application number	US-201816008037-A
Country	US
Kind code	B2
Filing date	Jun 14, 2018
Priority date	Aug 26, 2014
Publication date	Oct 29, 2019
Grant date	Oct 29, 2019

Abstract

A bio-sensing apparatus is used to sense a biopolymer. The bio-sensing apparatus includes a sensing element, a light-transmitting element and a surface plasma resonance layer. The bio-sensing apparatus is disposed on the sensing element. The surface plasma resonance layer is disposed on the light-transmitting element, and is used to receive the biopolymer. The light-transmitting element is disposed between the surface plasma resonance layer and the sensing element.

First claim

What is claimed is:

1. A bio-sensing apparatus, adapted to sense a biopolymer, the bio-sensing apparatus comprising:
a sensing element, having a sensing surface;
a spatial filter element disposed on the sensing surface and comprising spatial filter sheets, wherein each of the spatial filter sheets comprising:
a light-transmitting layer; and
a spatial filter layer, disposed on the light-transmitting layer and having light-transmitting portions and light-blocking portions, each of the light-transmitting portions is surrounded by light-blocking portions of the light-blocking portions, wherein light-transmitting layers of the spatial filter sheets and spatial filter layers of the spatial filter sheets are stacked alternately in a normal direction of the sensing surface;

a light-transmitting element disposed on the spatial filter element, the spatial filter element is disposed between the light-transmitting element and the sensing element; and
a surface plasma resonance layer disposed on the light-transmitting element and adapted to receive the biopolymer, the light-transmitting element is disposed between the surface plasma resonance layer and the spatial filter element.

2. The bio-sensing apparatus as recited in claim 1 , wherein the light-blocking portions and the light-transmitting portions are arranged in alternation on the sensing surface along a first direction and a second direction, the first direction is perpendicular to the second direction, and the first direction and the second direction are all perpendicular to the normal direction of the sensing surface.

3. The bio-sensing apparatus as recited in claim 2 , wherein the light-blocking portions and the light-transmitting portions are arranged in a chessboard-type manner.

4. The bio-sensing apparatus as recited in claim 1 , wherein the light-transmitting portions expose sensing units of the sensing element, spacing between the light-transmitting portions is S, a width of each of the light-transmitting portions is W, and 0.3 W<S, a thickness of a light-transmitting layer of a first spatial filter sheet of the spatial filter sheets is T 1 , a thickness of a light-transmitting layer of a second spatial filter sheet of the spatial filter sheets is T 2 , and the bio-sensing apparatus satisfies:

0.3
×

W
S

×
T
⁢

⁢
1

≤

T
⁢

⁢
2

≤

T
⁢

⁢
1.

5. The bio-sensing apparatus as recited in claim 4 , wherein the bio-sensing apparatus satisfies:

0.3
×

W
S

×
T
⁢

⁢
1

≤

T
⁢

⁢
2

≤

0.9
×

W
S

×
T
⁢

⁢
1.

6. The bio-sensing apparatus as recited in claim 4 , wherein the bio-sensing apparatus satisfies:

0.9
×

W
S

×
T
⁢

⁢
1

≤

T
⁢

⁢
2

≤

T
⁢

⁢
1.

7. The bio-sensing apparatus as recited in claim 1 , wherein the spatial filter layers comprises a first spatial filter layer, a second spatial filter layer and a third spatial filter layer, the first spatial filter layer, the second spatial filter layer and the third spatial filter layer are overlapped with each other, light-transmitting portions of the first spatial filter layer comprises first light-transmitting portions, light-transmitting portions of the second spatial filter layer comprises second light-transmitting portions, light-transmitting portions of the third spatial filter layer comprises third light-transmitting portions, and the spatial filter element satisfies a condition below:
a size of each of the third light-transmitting portions is larger than or equal to a size of each of the second light-transmitting portions, and the size of each of the second light-transmitting portions is larger than a size of each of the first light-transmitting portions; or
the size of each of the third light-transmitting portions is larger than the size of each of the second light-transmitting portions, and the size of each of the second light-transmitting portions is larger than or equal to the size of each of the first light-transmitting portions.

8. The bio-sensing apparatus as recited in claim 7 , wherein the size of each of the third light-transmitting portions is larger than the size of each of the second light-transmitting portions, the size of each of the second light-transmitting portions is larger than the size of each of the first light-transmitting portions, and the first spatial filter layer, the second spatial filter layer, and the third spatial filter layer are sequentially arranged from the sensing element towards the light-transmitting element or from the light-transmitting element towards the sensing element.

9. The bio-sensing apparatus as recited in claim 1 , wherein light-transmitting portions of the spatial filter layers corresponding to one sensing unit of the sensing element are arranged along an oblique direction, the oblique direction and a normal direction of a surface of the light-transmitting element have an included angle θ, and 0°<θ<90°.

10. The bio-sensing apparatus as recited in claim 9 , wherein the light-transmitting portions of a spatial filter layer are arranged at a spacing P, at least one light-transmitting portion of the spatial filter layer has a diameter K, the spatial filter layer is disposed on a light-transmitting layer, the light-transmitting layer has a thickness H, and the diameter K, the spacing P, and the thickness H satisfy:

(

H

P
-

Assignees

• Gingy Technology Inc

Inventors

• Wu Jen-Chieh
• Chung Chuck
• Lin Patrick
• Huang Cheng-Jyun
• You Kuo-Liang

Classifications

• H10W72/884

  Die-attach connectors and bond wires · CPC title

• H10W90/754

  between a chip and a stacked insulating package substrate, interposer or RDL · CPC title

• H10W72/5449

  not being orthogonal to a side surface of the chip, e.g. fan-out arrangements · CPC title

• H10W90/734

  between a chip and a stacked insulating package substrate, interposer or RDL · CPC title

• G02B27/0988

  Diaphragms, spatial filters, masks for removing or filtering a part of the beam · CPC title