System and method for mass spectrometry imaging
US-2024389905-A1 · Nov 28, 2024 · US
US10456200B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10456200-B2 |
| Application number | US-9107506-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 25, 2006 |
| Priority date | Oct 25, 2005 |
| Publication date | Oct 29, 2019 |
| Grant date | Oct 29, 2019 |
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The position of a metal marker 5 relative to an optical fiber 6 is fixed, and the metal marker 5 can be moved up close to a target site such as a thrombus. It is preferable that the position, in an optical fiber longitudinal direction, of a front-end face of the optical fiber 6 is coincident with the position, in an optical fiber longitudinal direction, of a front-end face of the metal marker 5 . More specifically, since the distance between the target site and the front end of the optical fiber 6 is known by radiography, it becomes unnecessary to use a large quantity of contrast agent and irradiate a laser beam depending on skill and intuition, and therefore an effective laser beam irradiation becomes possible.
Opening claim text (preview).
The invention claimed is: 1. An examination system comprising: a catheter including: a resinous capillary tube, comprising: a trunk capillary tube comprised of resin, and having a front-portion that is surrounded by a marker made of platinum, and a branch portion that forms a first branched capillary tube comprised of resin and a second branched capillary tube comprised of resin, wherein the trunk capillary tube comprises a first through hole for at least one of a wire and a contrast agent, and a second through hole for an optical fiber, the wire passing through the first through hole, and the optical fiber passing through the second through hole; a branching adapter fixed to the first branched capillary tube, and comprising resin and having a third branched capillary tube and a fourth branched capillary tube, wherein a through hole of the third branched capillary tube is continuous with the first through hole and comprises the wire, the fourth branched capillary tube comprising the contrast agent; the optical fiber being fixed to the trunk capillary tube and in the second branched capillary tube, and having a position relative to the marker that is fixed in an optical fiber longitudinal direction; wherein a position, in the optical fiber longitudinal direction, of a front-end face of the optical fiber is coincident with a position, in the optical fiber longitudinal direction, of a front-end face of the marker; a laser light source which emits light to be inputted to the optical fiber of the catheter, the light being emitted from the front-end face of the optical fiber comprising a pulsed laser beam; a drive circuit of the laser light source; and a controller, and wherein laser driving conditions of the drive circuit are set by the controller, and the laser driving conditions of a center wavelength λ, a pulse width T, and a repetition frequency f of the pulsed laser beam are set as follows: 520 nm≤λ≤590 nm, 1 μsec≤T≤100 μsec, and 1 Hz≤f<10 Hz, a position of the optical fiber is shifted from the central axis of the second branched capillary tube to an off-center position at the branch portion of the trunk capillary tube; and a position of the first through hole is shifted from the central axis of the first branched capillary tube to an off-center position at the branch portion of the trunk capillary tube. 2. A thrombus removing device comprising: a catheter including: a resinous capillary tube, comprising: a trunk capillary tube comprised of resin, and having a front-portion that is surrounded by a marker made of platinum, and a branch n portion that forms a first branched capillary tube comprised of resin and a second branched capillary tube comprised of resin, wherein the trunk capillary tube comprises a first through hole for at least one of a wire and a contrast agent, and a second through hole for an optical fiber, the wire passing through the first through hole, and the optical fiber passing through the second through hole; a branching adapter fixed to the first branched capillary tube, and comprising resin and having a third branched capillary tube and a fourth branched capillary tube, wherein a through hole of the third branched capillary tube is continuous with the first through hole and comprises the wire, the fourth branched capillary tube comprising the contrast agent; the optical fiber being fixed to the trunk capillary tube and in the second branched capillary tube, and having a position relative to the marker that is fixed in an optical fiber longitudinal direction; wherein a position, in the optical fiber longitudinal direction, of a front-end face of the optical fiber is coincident with a position, in the optical fiber longitudinal direction, of a front-end face of the marker; a laser light source which emits light to be inputted to the optical fiber of the catheter, the light being emitted from the front-end face of the optical fiber comprising a pulsed laser beam; a drive circuit of the laser diode; and a controller, and wherein laser driving conditions of the drive circuit are set by the controller, and the laser driving conditions of a center wavelength λ, a pulse width T, and a repetition frequency f of the pulsed laser beam are set as follows: 520 nm≤λ≤590 nm, 1 μsec≤T≤100 μsec, and 1 Hz≤f<10 Hz, a position of the optical fiber is shifted from the central axis of the second branched capillary tube to an off-center portion at the branch of the trunk capillary tube; and; a position of the first through hole is shifted from the central axis of the first branched capillary tube to an off-center position at the branch portion of the trunk capillary tube. 3. A thrombus removing device comprising: a catheter including: a resinous capillary tube, comprising: a trunk capillary tube comprised of resin, and having front-portion that is surrounded by a marker made of platinum, and a branch portion that forms a first branched capillary tube comprised of resin and a second branched capillary tube comprised of resin, wherein the trunk capillary tube comprises a first through hole for at least one of a wire and a contrast agent, and a second through hole for an optical fiber, the wire passing through the first through hole, and the optical fiber passing through the second through hole; a branching adapter fixed to the first branched capillary tube, and comprising resin and having a third branched capillary tube and a fourth branched capillary tube, wherein a through hole of the third branched capillary tube is continuous with the first through hole and comprises the wire, the fourth branched capillary tube comprising the contrast agent; the optical fiber being fixed to the trunk capillary tube and in the second branched capillary tube, and having a position relative to the marker that is fixed in an optical fiber longitudinal direction; wherein a laser light source which emits light to be inputted to the optical fiber of the catheter, the light being emitted from a front-end face of the optical fiber comprising a pulsed laser beam, a position of the optical fiber is shifted from the central axis of the second branched capillary tube to an off-center position at the branch portion of the trunk capillary tube; and a position of the first through hole is shifted from the central axis of the first branched capillary tube to an off-enter position at the branch portion of the trunk capillary tube. 4. A thrombus removing device according to claim 3 , further comprising: a drive circuit of the laser light source; and a controller for the drive circuit. 5. A thrombus removing device according to claim 4 , wherein the laser light source is a diode-pumped solid state laser.
for contrast media · CPC title
characterized by lumina being arranged side-by-side · CPC title
with a catheter (A61B18/26, A61B18/28 take precedence) · CPC title
Markers, e.g. radio-opaque or breast lesions markers · CPC title
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