Method for purifying 1,4-diaminobutane

Patent metadata

Field	Value
Publication number	US-10450262-B2
Application number	US-201615572381-A
Country	US
Kind code	B2
Filing date	May 4, 2016
Priority date	May 8, 2015
Publication date	Oct 22, 2019
Grant date	Oct 22, 2019

Abstract

A method for purifying 1,4-diaminobutane comprising the steps of: separating a second composition including carbonate salt of 1,4-diaminobutane from a first composition including carbonate salt of 1,4-diaminobutane by distillation; and removing carbonate from carbonate salt of 1,4-diaminobutane included in the second composition to recover 1,4-diaminobutane.

First claim

The invention claimed is:

1. A method for purifying 1,4-diaminobutane comprising the steps of:
separating a second composition comprising carbonate salt of 1,4-diaminobutane from a first composition comprising carbonate salt of 1,4-diaminobutane by distillation; and
removing carbonate from the carbonate salt of 1,4-diaminobutane comprised in the second composition to recover 1,4-diaminobutane.

2. The method according to claim 1 , wherein the carbonate salt of 1,4-diaminobutane is at least one of 1,4-diaminobutane carbonate and 1,4-diaminobutane bicarbonate.

3. The method according to claim 1 , wherein the first composition is a fermented broth or a concentrate thereof.

4. The method according to claim 3 , wherein the concentrate is prepared by concentrating the fermented broth at a vapor temperature in a range of about 10° C. to 100° C. and a pressure in a range of about 10 mmHg to about 760 mmHg.

5. The method according to claim 3 , wherein the pH of the concentrate is 10.0 or higher.

6. The method according to claim 1 , wherein 70 wt % or more of the carbonate salt of 1,4-diaminobutane comprised in the first composition is separated by the distillation.

7. The method according to claim 1 , wherein the distillation is performed at a vapor temperature in a range of about 30° C. to 158° C. and a pressure in a range of about 10 mmHg to about 760 mmHg.

8. The method according to claim 1 , wherein the pH of the second composition is 10.0 or higher.

9. The method according to claim 1 , wherein the removing of the carbonate is performed by fractional distillation.

10. The method according to claim 9 , wherein the fractional distillation is performed at a vapor temperature in a range of about 100° C. to 230° C. and a pressure in a range of about 1 atm to about 5 atm.

11. The method according to claim 9 , wherein the fractional distillation is performed using a distillation tower.

12. The method according to claim 11 , wherein the 1,4-diaminobutane is recovered from a lower part of the distillation tower, wherein the lower part of the distillation tower is disposed below a region into which the second composition is inserted into the distillation tower.

13. A method for purifying 1,4-diaminobutane comprising the steps of:
culturing a microorganism producing 1,4-diaminobutane in a medium while being provided with a nitrogen source to produce carbonate salt of 1,4-diaminobutane;
preparing a fermented broth or a concentrate thereof that comprises carbonate salt of 1,4-diaminobutane;
separating a third composition comprising carbonate salt of 1,4-diaminobutane by distillation of the fermented broth or a concentrate thereof; and
removing carbonate from the 1,4-diaminobutane carbonate comprised in the third composition to recover 1,4-diaminobutane, and

wherein the nitrogen source is at least one selected from ammonia, ammonium salt of an organic compound, and a carbonate-based inorganic compound.

14. The method according to claim 13 , wherein the concentrate is prepared by concentrating the fermented broth at a vapor temperature in a range of about 10° C. to 100° C. and a pressure in a range of about 10 mmHg to about 760 mmHg.

15. The method according to claim 13 , wherein the pH of the concentrate is 10.0 or higher.

16. The method according to claim 13 , further comprising removing bacterial cells from the fermented broth before the separating of the third composition.

17. The method according to claim 13 , wherein the carbonate salt of 1,4-diaminobutane comprises at least one of 1,4-diaminobutane carbonate and 1,4-diaminobutane bicarbonate.

18. The method according to claim 13 , wherein 70 wt % or more of the carbonate salt of 1,4-diaminobutane comprised in the third composition is separated by the distillation.

19. The method according to claim 13 , wherein the distillation is performed at a vapor temperature in a range of about 30° C. to 158° C. and a pressure in a range of about 10 mmHg to about 760 mmHg.

20. The method according to claim 13 , wherein the pH of the third composition is 10.0 or higher.

21. The method according to claim 13 , wherein the removing of the carbonate is performed by fractional distillation.

22. The method according to claim 21 , wherein the fractional distillation is performed at a vapor temperature in a range of about 100° C. to 230° C. and a pressure in a range of about 1 atm to about 5 atm.

23. The method according to claim 21 , wherein the fractional distillation is performed using a distillation tower.

24. The method according to claim 23 , wherein the 1,4-diaminobutane is recovered from a lower part of the distillation tower, wherein the lower part of the distillation tower is disposed blow a region into which the third composition is inserted into the distillation tower.

Assignees

• Cj Cheiljedang Corp

Inventors

• Gwak Won Sik
• Li Hong Xian
• Won Hyun Ju
• Lee Hyo Hyoung
• Na Kyung Su
• Park Su Jin
• Yang Young Lyeol
• Um Hye Won
• Oh Chang Yub
• Lee Kyoung Min

Classifications

• C12P13/00

  Preparation of nitrogen-containing organic compounds · CPC title

• C07C211/09

  Diamines · CPC title

• C07C209/86 Primary

  Separation · CPC title

• C07C209/84

  Purification · CPC title

• C12P13/001

  Amines; Imines · CPC title