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Collagen scaffolds, medical implants with same and methods of use
US10449270B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10449270-B2 |
| Application number | US-201715443003-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 27, 2017 |
| Priority date | Jun 22, 2006 |
| Publication date | Oct 22, 2019 |
| Grant date | Oct 22, 2019 |
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- Title
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Abstract
Official abstract text for this publication.
The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific embodiment of the invention concerns implantable glucose sensors. Sensors comprising a collagen scaffold of the invention have improved biocompatibility by minimizing tissue reactions while stimulating angiogenesis. The subject invention also concerns methods for preparing collagen scaffolds of the invention. The subject invention also concerns sensors that have a collagen scaffold of the invention around the exterior of the sensor.
First claim
Opening claim text (preview).
We claim: 1. A device having enhanced biocompatibility for implantation into the body or tissue of a person or animal, wherein said device comprises a biocompatible collagen scaffold and/or coating embedded in a nordihydroguaiaretic acid (NDGA) bisquinone polymer matrix; and wherein said device comprises a sensor. 2. The device according to claim 1 , wherein said device is a glucose sensor. 3. The device according to claim 1 , wherein said device comprises an epoxy coating underneath said collagen scaffold and/or coating. 4. The device according to claim 3 , wherein said epoxy coating is an epoxy-polyurethane coating. 5. The device according to claim 1 , wherein said collagen scaffold and/or coating comprises open pores of about 10 μm to about 200 μm in diameter (mean). 6. The device according to claim 5 , wherein the mean pore size of said collagen scaffold and/or coating is about 60 μm or less in diameter. 7. The device according to claim 5 , wherein the mean pore size of said collagen scaffold and/or coating is between about 40 μm to about 80 μm in diameter. 8. The device according to claim 5 , wherein said pores are regularly distributed in said collagen scaffold and/or coating. 9. The device according to claim 5 , wherein said pores form an interconnected pore structure in said collagen scaffold and/or coating. 10. The device according to claim 1 , wherein said collagen scaffold and/or coating comprises an antimicrobial, anti-inflammatory, and/or angiogenic compound, drug or growth factor.
Assignees
Inventors
Classifications
Treatment of implants to prevent calcification or mineralisation in vivo · CPC title
containing macromolecular fillers · CPC title
Porous materials, {e.g. foams or sponges} · CPC title
Macromolecular materials · CPC title
Macromolecular materials · CPC title
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- What does patent US10449270B2 cover?
- The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific embodiment of the invention concerns implantable glucose sensors. Sensors comprising a collagen scaffold of the invention have improved biocompatibility by minimizing tissue reactions while stimulating ang…
- Who is the assignee on this patent?
- Ju Young Min, Moussy Francis, Koob Thomas J, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61L27/24. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).