Process for producing a preparation in powder form containing at least one carotenoid

Patent metadata

Field	Value
Publication number	US-10449153-B2
Application number	US-201615145373-A
Country	US
Kind code	B2
Filing date	May 3, 2016
Priority date	Jun 30, 2005
Publication date	Oct 22, 2019
Grant date	Oct 22, 2019

Abstract

A preparation in the form of a powder containing: (a) at least one carotenoid, (b) at least one modified starch, and (c) sucrose; wherein the at least one carotenoid is present in the powder in an amount of 1 to 25% by weight, based on the weight of the powder; and wherein the at least one carotenoid and the sucrose are present in the powder in a ratio by weight of 1:2 to 1:80.

First claim

We claim:

1. A process for producing a preparation in powder form, comprising at least one carotenoid, which comprises
i) suspending one or more carotenoids in crystalline form in an aqueous molecular dispersed or colloidal solution of at least one modified starch and sucrose,
ii) grinding the suspended particles, and
iii) subsequently converting the suspension optionally in the presence of a coating material into a dry powder;
where the suspension comprises in process step ii), based on the dry matter of the aqueous suspension, from 1 to 25% by weight of at least one carotenoid, and the ratio of carotenoid a) to sucrose c) is from 1:2 to 1:80 by weight and
said at least one modified starch is present in an amount from 5 to 30% by weight, based on the dry matter of the aqueous suspension and
wherein the ground carotenoid particles after the grinding process have a degree of crystallinity which is greater than 80%.

2. A process for producing a preparation in powder form, comprising at least one carotenoid, which comprises
i) suspending one or more carotenoids in crystalline form in an aqueous molecular dispersed or colloidal solution of modified starch,
ii) grinding the suspended particles,
iii) mixing the ground suspension with sucrose, and
iv) subsequently converting the suspension optionally in the presence of a coating material into a dry powder,
where the suspension comprises after process step iii), based on the dry matter of the aqueous suspension, from 1 to 25% by weight of at least one carotenoid, and the ratio of carotenoid a) to sucrose c) is from 1:2 to 1:80 by weight and
said at least one modified starch is present in an amount from 5 to 30% by weight, based on the dry matter of the aqueous suspension and
wherein the ground carotenoid particles after the grinding process have a degree of crystallinity which is greater than 80%.

3. The process according to claim 1 , wherein the one or more carotenoids are compounds selected from the group consisting of β-carotene, lycopene, zeaxanthin, lutein and mixtures thereof.

4. The process according to claim 2 , wherein the one or more carotenoids are compounds selected from the group consisting of β-carotene, lycopene, zeaxanthin, lutein and mixtures thereof.

5. The process according to claim 3 , wherein the modified starch is octenylsuccinate starch.

6. The process according to claim 4 , wherein the modified starch is octenylsuccinate starch.

7. The process according to claim 2 , which comprises
i) suspending one or more carotenoids in crystalline form wherein said one or more carotenoids is selected from the group consisting of β-carotene, lutein, zeaxanthin and lycopene or mixtures thereof in an aqueous molecular or colloidal solution of sodium octenylsuccinate starch,
ii) grinding the suspended particles, and
iii) mixing the ground suspension with sucrose, and
iv) subsequently converting the suspension optionally in the presence of a coating material into a dry powder,
where the suspension comprises after process step iii), based on the dry matter of the aqueous suspension, from 8 to 13% by weight of at least one carotenoid a) selected from the group consisting of β-carotene, lutein, zeaxanthin and lycopene or mixtures thereof, and the ratio of carotenoid a) to sucrose c) is from 1:5 to 1:10 by weight.

8. The process according to claim 1 , wherein the one or more carotenoids are β-carotene.

9. The process according to claim 7 , wherein the one or more carotenoids are β-carotene.

10. The process according to claim 1 , wherein the one or more carotenoids are lycopene.

11. The process according to claim 7 , wherein the one or more carotenoids are lycopene, zeaxanthin, lutein and mixtures thereof.

12. The process according to claim 1 , wherein the one or more carotenoids are zeaxanthin.

13. The process according to claim 7 , wherein the one or more carotenoids are zeaxanthin.

14. The process according to claim 1 , wherein the one or more carotenoids are lutein.

15. The process according to claim 7 , wherein the one or more carotenoids are lutein.

16. A process for producing an aqueous carotenoid-containing suspension, which comprises
i) suspending one or more carotenoids in crystalline form in an aqueous molecular dispersed or colloidal solution of at least one modified starch and sucrose, and
ii) grinding the suspended particles,
where the suspension comprises after process step ii), based on the dry matter of the aqueous suspension, from 1 to 25% by weight of at least one carotenoid, and the ratio of carotenoid a) to sucrose c) is from 1:2 to 1:80 by weight and
said at least one modified starch is present in an amount from 5 to 30% by weight, based on the dry matter of the aqueous suspension and
wherein the ground carotenoid particles after the grinding process have a degree of crystallinity which is greater than 80%.

17. The process according to claim 1 , wherein said at least one modified starch is an amount from 8 to 26% by weight, based on the dry matter of the aqueous suspension.

18. The process according to claim 2 , wherein said at least one modified starch is an amount from 8 to 26% by weight, based on the dry matter of the aqueous suspension.

19. The process according to claim 16 , wherein said at least one modified starch is an amount from 8 to 26% by weight, based on the dry matter of the aqueous suspension.

20. The process according to claim 16 , wherein the one or more carotenoids are compounds selected from the group consisting of β-carotene, lycopene, zeaxanthin, lutein and mixtures thereof and the modified starch is octenylsuccinate starch.

21. The process according to claim 7 , wherein the average particle size after grinding is from 0.02 to 100 μm.

22. The process according to claim 7 , wherein the average particle size after grinding is from 0.05 to 1 μm.

23. The process according to claim 7 , wherein the grinding takes place using a ball mill.

24. The process according to claim 7 , wherein the ground carotenoid particles after the grinding process have a degree of crystallinity which is 95 to 99%.

25. The process according to claim 7 , wherein the ratio of carotenoid to sucrose of 1:5 to 1:10.

Assignees

• Basf Se

Inventors

• Musaeus Nina
• Jensen Carsten Ninn

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A23L5/44

  using carotenoids or xanthophylls · CPC title

• A23L33/155

  Vitamins A or D · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61K47/06

  Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite · CPC title