Tissue modification devices, systems, and methods

Patent metadata

Field	Value
Publication number	US-10443107-B2
Application number	US-201816044845-A
Country	US
Kind code	B2
Filing date	Jul 25, 2018
Priority date	Sep 3, 2015
Publication date	Oct 15, 2019
Grant date	Oct 15, 2019

Abstract

A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker).

First claim

What is claimed is:

1. A tissue modification apparatus comprising:
a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue within the plane;
a first plurality of force dividers aligned in the plane with the first plurality of grippers;
wherein the first plurality of grippers are connected to a first force actuator via a plurality of pivoted connections to the first plurality of force dividers, the first plurality of grippers and the first plurality of force dividers are adapted to pivot about an axis perpendicular to the plane.

2. The tissue modification apparatus of claim 1 , further comprising a second plurality of grippers aligned in the plane opposite the first plurality of grippers, the second plurality of grippers being adapted to secure a second edge of a patch of tissue, the second plurality of grippers each being adapted to pivot about an axis perpendicular to the plane, the first plurality of grippers being adapted to pull the tissue in a direction opposite the second plurality of grippers such that a patch of tissue secured between the first and second plurality of grippers can be stretched along a first orientation.

3. The tissue modification apparatus of claim 2 , wherein the second plurality of grippers are each secured to a second force actuator via pivoted connections such that the first and second force actuators are adapted to pull the first and second pluralities of grippers in opposite directions such that a patch of tissue secured between the first and second plurality of grippers can be stretched along a first orientation.

4. The tissue modification apparatus of claim 2 , wherein the second plurality of grippers are attached to a stationary object via pivoted connections.

5. The tissue modification apparatus of claim 2 , further comprising a third plurality of grippers and a fourth plurality of grippers, the third plurality of grippers being aligned in the plane adjacent the first plurality of grippers and the fourth plurality of grippers being aligned in the plane opposite the third plurality of grippers, the third and fourth pluralities of grippers each being adapted to secure a third and fourth edge of a patch of tissue, wherein at least the third plurality of grippers are each secured to a third force actuator adapted to pull the third plurality of grippers in a direction opposite the fourth plurality of grippers such that a patch of tissue secured between the first, second, third, and fourth plurality of grippers can be stretched along both the first orientation and a second orientation.

6. The tissue modification apparatus of claim 5 , further comprising a fourth force actuator and the third and fourth force actuators are adapted to pull the third and fourth pluralities of grippers in opposite directions.

7. The tissue modification apparatus of claim 5 , wherein each of the grippers in the third and fourth pluralities of grippers are adapted to pivot in the plane via a plurality of pivoted connections.

8. The tissue modification apparatus of claim 1 , wherein each of the grippers is secured to a distal end of a beam, each beam being pivotally connected to one of the first plurality of force dividers.

9. The tissue modification apparatus of claim 8 , wherein each force divider is pivotally connected to either another force divider or to one of said force actuators and each force divider includes at least three pivoted connections.

10. The tissue modification apparatus of claim 8 , further comprising a beam fixation device adapted to lock grippers in one of said pluralities of grippers into a predetermined spacing, the beam fixation device being adapted to be released to allow for the grippers to pivot after being secured to an edge of tissue.

11. The tissue modification apparatus of claim 8 , wherein each beam is at least 1 cm long.

Assignees

• Boston Scient Scimed Inc

Inventors

• Anderson-Cunanan Crystal Marie
• Foster Daniel J
• Mccarthy Ray
• Byron Mary M
• Wulfman David Robert
• Swehla Bradley S

Classifications

• C14B17/08

  Fastening devices, e.g. clips for leather-stretching · CPC title

• C14B1/26

  Leather tensioning or stretching frames; Stretching-machines; Setting-out boards; Pasting boards (pasting processes C14B1/60; fastening devices C14B17/08) · CPC title

• C14B1/00 Primary

  Manufacture of leather; Machines or devices therefor {(machines specially adapted for forming upper shoe blanks or shoe leggings by stretching A43D8/003)} · CPC title

• A61L27/3691

  characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation · CPC title

• A61L2430/40

  Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking · CPC title