Methods and devices for activating brown adipose tissue with light

Patent metadata

Field	Value
Publication number	US-10441808-B2
Application number	US-201113977536-A
Country	US
Kind code	B2
Filing date	Dec 21, 2011
Priority date	Dec 29, 2010
Publication date	Oct 15, 2019
Grant date	Oct 15, 2019

Abstract

Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.

First claim

What is claimed is:

1. A medical method, comprising:
positioning a housing in contact with tissue of a patient, the housing having housed therein a light source operatively positioned proximate to a depot of brown adipose tissue;
activating the light source to deliver light energy to the patient to activate the brown adipose tissue and increase energy expenditure of the brown adipose tissue;
after the activating, sensing with a sensor a characteristic of the brown adipose tissue and transmitting the sensed characteristic to a controller operatively coupled to the light source;
changing, with the controller, the light energy being delivered by the light source based on the sensed characteristic, wherein the changing includes either turning off the light source to stop delivering the light energy or altering at least one of pulse duration, power, duty cycle, frequency of delivery, and wavelength of the light energy;
delivering a light activatable medium to the depot of brown adipose tissue, the light activatable medium being configured to respond to the light energy when the light energy is delivered to the patient, the response of the light activatable medium causing activation of the brown adipose tissue; and
delivering a different light activatable medium to the depot of brown adipose tissue, wherein:
the housing has an additional light source housed therein positioned proximate to the depot of brown adipose tissue;
the method further comprises activating the additional light source to deliver additional light energy to the patient to activate the brown adipose tissue and increase energy expenditure of the brown adipose tissue;
the light energy has a first wavelength and the additional light energy has a different wavelength;
the light activatable medium is activated by the first wavelength but is not activatable by the different wavelength; and
the different light activatable medium is activated by the different wavelength but is not activatable by the first wavelength.

2. The method of claim 1 , wherein the first wavelength of the light energy is in an infrared range of about 0.7 to 1000 μm.

3. The method of claim 1 , wherein the first wavelength of the light energy is in an ultraviolet range of about 0.01 to 0.4 μm.

4. The method of claim 1 , wherein delivering the light activatable medium to the depot of brown adipose tissue comprises alternating at least once between delivering the light activatable medium to the patient during a first period of time and not delivering the light activatable medium to the patient during a second period of time.

5. The method of claim 1 , further comprising targeting the light energy to a nerve innervating the brown adipose tissue to activate the brown adipose tissue.

6. The method of claim 1 , wherein the depot of brown adipose tissue is in a supraclavicular region of the patient.

7. The method of claim 1 , wherein positioning the housing in contact with tissue of the patient comprises transcutaneously applying the housing to an exterior skin surface of the patient.

8. The method of claim 1 , wherein positioning the housing in contact with tissue of the patient comprises subcutaneously positioning at least a portion of the housing within the patient.

9. The method of claim 1 , wherein the light energy delivered by the light source is continuously delivered to the patient for a predetermined amount of time in a range of one day to four weeks.

10. The method of claim 9 , further comprising
after the light energy has been continuously delivered to the patient for the predetermined amount of time, removing the housing from the patient;
repositioning the housing in contact with tissue of the patient with the light source proximate to another depot of brown adipose tissue; and
activating the light source to deliver additional light energy by the light source to the patient to activate the other depot of brown adipose tissue and increase energy expenditure of the other depot of brown adipose tissue.

11. The method of claim 10 , wherein the depot of brown adipose tissue is in a supraclavicular region on one of a left and right side of a sagittal plane of the patient, and the other depot of brown adipose tissue is in a supraclavicular region on the other of the left and right side of the sagittal plane of the patient.

12. The method of claim 10 , further comprising, after the additional light energy has been delivered to the patient, in response to a trigger event, removing the housing from contact with tissue of the patient proximate to the other depot of brown adipose tissue and repositioning the housing to be in contact with another area of tissue of the patient with the light source proximate to a third depot of brown adipose tissue, wherein the trigger event includes at least one of the patient eating, the patient resting, a threshold temperature of the patient, a directional orientation of the patient, a change in the patient's weight, a change in the patient's tissue impedance, manual activation by the patient or other human, and a blood chemistry change in the patient.

13. The method of claim 9 , wherein the predetermined amount of time is at least seven days.

14. The method of claim 9 , further comprising waiting a second predetermined amount of time after the light source has delivered the light energy to the patient and then activating the light source to deliver additional light energy to the patient to activate the depot of brown adipose tissue and increase energy expenditure of the brown adipose tissue.

15. The method of claim 1 , wherein the characteristic of the depot of brown adipose tissue includes at least one of temperature and an electrical signal.

Assignees

• Harris Jason L
• Kaplan Lee M
• Plescia David N
• Aronhalt Taylor W
• Voegele James W
• Stylopoulos Nicholas
• Ethicon Endo Surgery Inc
• Massachusetts Gen Hospital

Inventors

• Harris Jason L
• Kaplan Lee M
• Plescia David N
• Aronhalt Taylor W
• Voegele James W
• Stylopoulos Nicholas

Classifications

• A61N5/062

  Photodynamic therapy, i.e. excitation of an agent · CPC title

• A61M2230/201

  Glucose concentration · CPC title

• A61M2230/06

  Heartbeat rate only · CPC title

• A61N5/0613 Primary

  Apparatus adapted for a specific treatment · CPC title

• A61M5/14276 Primary

  specially adapted for implantation · CPC title