Systems and methods for broad line fundus imaging

Patent metadata

Field	Value
Publication number	US-10441167-B2
Application number	US-201615246926-A
Country	US
Kind code	B2
Filing date	Aug 25, 2016
Priority date	Mar 15, 2013
Publication date	Oct 15, 2019
Grant date	Oct 15, 2019

Abstract

Systems and methods for Broad Line Fundus Imaging (BLFI), an imaging approach that is a hybrid between confocal and widefield imaging systems, are presented. These systems and methods are focused on improving the quality and signal of broad line fundus images or imaging methods to create high contrast and high resolution fundus images. Embodiments related to improved pupil splitting, artifact removal, reflex minimization, adaptable field of view, instrument alignment and illumination details are considered.

First claim

What is claimed:

1. A system for imaging the eye of a patient, said system comprising:
a light source for producing a beam of radiation;
optics for directing the beam of radiation to the retina of the eye of a patient to illuminate a two-dimensional region on the retina;
a detector for collecting light returning from the eye and generating output signals in response thereto;
pupil splitting optics for separating the light illuminating the retina from light returning from the retina, wherein the pupil splitting optics establish two regions of illumination outside of one region of detection and wherein the regions of illumination and the region of detection are separated by a region through which no radiation passes, and wherein the pupil splitting optics can be adjusted so that either only one or both of the illumination regions are used during imaging; and

means for moving the beam to various locations across the retina of the eye such that a series of two dimensional regions of the eye are illuminated.

2. A system as recited in claim 1 , wherein the pupil splitting is accomplished in a first direction selected such that the etendue of the illumination beam is lower in the first direction of the pupil splitting than in the orthogonal direction.

3. A system as recited in claim 2 , wherein the extent of the illumination in the pupil of the eye is narrower in the lower etendue direction.

4. A system as recited in claim 3 , wherein the angular distribution of the illumination light in the pupil is lower in the lower etendue direction than in the orthogonal direction.

5. A system as recited in claim 2 , wherein the angular distribution of the illumination light in the pupil in the lower etendue direction is lower than in the orthogonal direction.

6. A system as recited in claim 2 , wherein the beam illuminates an area on the retina with a two-dimensional extent having a long axis and a short axis, and the splitting direction leads to a no-man's zone near the cornea which is oriented parallel to the long axis of the illuminated area on the retina.

7. A system as recited in claim 1 , wherein the means for moving the beam is a scanner.

8. A system as recited in claim 1 , wherein the means for moving the beam is a moving slit in front of the light source.

9. A system as recited in claim 1 , wherein the means for moving the beam is a transverse movement of the light source.

10. A system as recited in claim 1 , wherein optics direct returning light to different regions on the detector depending on the area of the retina being illuminated.

11. A system as recited in claim 1 , wherein optics direct returning light to the same region or regions on the detector regardless of the locations on the retina being illuminated.

12. A system as recited in claim 1 , further comprising:
generating an image from the collected light, wherein the transverse extent of the illumination is visible in the image;
using the sharpness of the line between the illuminated and unilluminated areas to optimize the focus of the imaging system.

13. A system as recited in claim 1 , wherein the light returning from the eye contains light reflected or emitted from other areas of the eye not illuminated by the source, and the system further comprises a processor for subtracting the detector signals corresponding to the other areas from the signals corresponding to the imaged region and for generating an image based on the subtraction.

14. A system as recited in claim 13 , wherein the optics for directing reflected or emitted light towards the detector direct the light to the same region or regions on the detector regardless of the locations on the retina being illuminated.

15. A system as recited in claim 14 , wherein the reflected light from unilluminated areas is collected at locations above and below the region on the detector where the reflected or emitted light from illuminated areas of the retina.

16. A system as recited in claim 1 , wherein only one illumination region of the pupil splitting optics used when the pupil of the eye is small.

17. A system as recited in claim 1 , wherein the illumination regions are separated vertically and only the lower illumination region is used during imaging.

18. A system as recited in claim 1 , wherein the light source comprises one or more LEDs and a laser and wherein the LEDs and laser are used for different imaging modalities.

19. A system as recited in claim 1 , further comprising an optical element for scattering the beam of radiation so that the beam of radiation is enlarged at the pupil plane of the system.

20. A system as recited in claim 19 , wherein the optical element is rotated during imaging.

Assignees

• Zeiss Carl Meditec Inc
• Zeiss Carl Meditec Ag

Inventors

• Bublitz Daniel
• Everett Matthew J
• Farkas Csaba
• Kempe Michael
• Qiu Yue
• Schmitt-Manderbach Tobias

Classifications

• A61B3/1025 Primary

  for confocal scanning · CPC title

• G02B21/0032

  Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers (G02B21/0036 - G02B21/008; means for illumination of specimens in general G02B21/06) · CPC title

• G02B21/0028

  specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes · CPC title

• A61B3/12

  for looking at the eye fundus, e.g. ophthalmoscopes (A61B3/13 takes precedence) · CPC title

• A61B3/14 Primary

  Arrangements specially adapted for eye photography · CPC title