Use of active substances for controlling virus infection in plants

Patent metadata

Field	Value
Publication number	US-10440952-B2
Application number	US-201716069242-A
Country	US
Kind code	B2
Filing date	Jan 12, 2017
Priority date	Jan 13, 2016
Publication date	Oct 15, 2019
Grant date	Oct 15, 2019

Abstract

The present invention relates to the use of specific active substances, alone or in combination, for controlling virus infections in plants and to a method for using said specific active substances for controlling said virus infections in the field of plant protection and the protection of materials.

First claim

The invention claimed is:

1. A method for controlling viral disease in plants, comprising applying to the plants at least one compound of formula (I):

wherein
R1 is a thienyl or phenyl, wherein said thienyl or phenyl may be substituted with one or more substituents independently selected from the group consisting of halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkylthio, ((C 1 -C 6 )alkoxy)(C 1 -C 6 )alkyl, ((C 1 -C 6 )alkylthio)(C 1 -C 6 )alkyl and phenyl; and
R2 is a phenyl which may be substituted with one or more substituents independently selected from the group consisting of halogen, (C 1 -C 6 )alkyl and (C 1 -C 6 )alkoxy.

2. The method according to claim 1 , wherein R1 is selected from the group consisting of 2-thienyl, phenyl, 3-methyl-2-thienyl, 5-methyl-2-thienyl, 2-methylphenyl, 4-methylphenyl, 4-phenyl-2-thienyl, 5-phenyl-2-thienyl, 4-bromo-2-thienyl, 5-bromo-2-thienyl, 5-chloro-2-thienyl, 4-bromo-5-methyl-2-thienyl, 4-bromo-5-ethyl-2-thienyl, 3-(methyl sulfanyl)-2-thienyl, 4-bromo-5-[(methylsulfanyl)methyl]-2-thienyl, 3-(methoxymethyl)-2-thienyl, 2,6-dimethylphenyl, 2,4,5-trimethylphenyl, 2,4,6-trimethylphenyl and 2,6-dichlorophenyl.

3. The method according to claim 1 , wherein R2 is selected from the group consisting of phenyl, 2-chlorophenyl, 2-fluorophenyl, 3-chlorophenyl, 4-fluorophenyl, 2,3-dichlorophenyl, 2,4-dichlorophenyl, 2,5-dichlorophenyl, 3,4-dichlorophenyl, 2-chloro-5-fluorophenyl, 2-methylphenyl, 4-methylphenyl, 2-methoxyphenyl, 3-methoxyphenyl and 4-methoxyphenyl.

4. The method according to claim 1 , wherein the control is based on a stimulation of the natural defense mechanism of plants against viruses.

5. The method according to claim 4 , wherein the natural defense mechanism of plants against viruses is a RNA-silencing based plant defense mechanism.

6. The method according to claim 1 , wherein said method is a preventive method.

7. The method according to claim 1 , wherein said plants are selected from the group consisting of cotton, flax, grapevine, fruit, vegetables, crop plants, ornamental plants for gardens and wooded area and genetically modified varieties of each of these plants.

8. The method according to claim 1 , wherein said plants are selected from the group consisting of Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp., Rubiaceae sp., Theaceae sp., Sterculiceae sp., Rutaceae sp.; Solanaceae sp., Liliaceae sp., Asteraceae sp., Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp., Alliaceae sp., Papilionaceae sp., Asteraceae sp., Brassicaceae sp., Fabacae sp., Papilionaceae sp., Solanaceae sp. and Chenopodiaceae sp.

9. The method according to claim 1 , wherein said viruses are selected from the group consisting of the following families or genus: Caulimoviridae, Geminiviridae, Bromoviridae, Closteroviridae, Comoviridae Potyviridae, Sequiviridae, Tombusviridae, Rhabdoviridae, Bunyaviridae, Partitiviridae, Rheoviridae, Capillovirus, Carlavirus, Enamovirus, Furovirus, Hordeivirus, Idaeovirus, Luteovirus, Marafivirus, Potexvirus, Sobemovirus, Tenuivirus, Tobamovirus, Tobravirus, Trichovirus, Tymovirus and Umbravirus.

10. The method according to claim 1 , wherein said viruses are selected from the group consisting of Turnip mosaic virus, turnip crinkle virus, bean pod mottle virus, cauliflower mosaic virus, tobacco mosaic virus, tomato bushy stunt virus, rice ragged stunt virus, cucumber mosaic virus, barley yellow dwarf virus, beet yellows virus, lettuce yellows virus, maise mosaic virus, peanut stunt virus and potato virus Y.

11. The method according to claim 1 , wherein the compound of formula (I) is applied by spraying to the plants.

12. The method according to claim 1 , wherein the compound of formula (I) is applied to the plants in an amount ranging from 0.01 to 5 kg/ha.

13. The method according to claim 1 , wherein R1 is selected from the group consisting of 2-methylphenyl, 4-methylphenyl, 2,6-dimethylphenyl, 2,4,5-trimethylphenyl, 2,4,6-trimethylphenyl and 2,6-dichlorophenyl.

14. The method according to claim 13 , wherein R2 is 2-chlorophenyl.

Assignees

• Bayer Cropscience Ag
• Bayer Corp Science Ag

Inventors

• Baltz Rachel
• Bernier David
• Jay-Brioudes Florence
• Knobloch Thomas
• Vitel Maxime
• Voinnet Olivier

Classifications

• C07D409/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D261/12

  Oxygen atoms · CPC title

• A61P31/12

  Antivirals · CPC title

• A61K31/42

  Oxazoles · CPC title

• A01N43/80 Primary

  five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2 · CPC title