Material comprising outer layer having entanglement of hydrophobic polymer host blended with anhydride functionalized hydrophobic polymer co-host and hydrophilic guest

Patent metadata

Field	Value
Publication number	US-10435523-B2
Application number	US-201615388355-A
Country	US
Kind code	B2
Filing date	Dec 22, 2016
Priority date	Oct 30, 2001
Publication date	Oct 8, 2019
Grant date	Oct 8, 2019

Abstract

The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.

First claim

We claim:

1. A material comprising:
(i) an outer layer comprising an entanglement; and
(ii) a hydrophilic outer surface of said outer layer,
wherein said entanglement comprises a physical blend of a hydrophobic polymer host and an anhydride functionalized hydrophobic polymer co-host, and a hydrophilic guest;
wherein said hydrophobic polymer host comprises a polyolefin;
wherein said anhydride functionalized hydrophobic polymer co-host comprises a polyolefin which has been functionalized with anhydride functional groups; and
wherein said hydrophilic guest comprises a salt of a glycosaminoglycan;
said entanglement having been synthesized by: (a) intermingling cloaked hydrophilic guest complexes with said physical blend of said host and said co-host; (b) crosslinking molecules of said guest with said guest; and (c) performing a hydrolysis reaction.

2. The material according to claim 1 , wherein: said co-host is selected from the group consisting of: maleic anhydride-graft-polyethylene, maleic anhydride-graft-polypropylene; and maleic anhydride-graft-polystyrene.

3. The material according to claim 1 , wherein said cloaked hydrophilic guest complexes are selected from the group consisting of silylated guest complexes and acylated guest complexes.

4. The material according to claim 3 , wherein said cloaked hydrophilic guest complexes are silylated guest complexes.

5. The material according to claim 1 , wherein said entanglement is surface treated with glycosaminoglycan.

6. The material according to claim 3 , wherein: said co-host is selected from the group consisting of: maleic anhydride-graft-polyethylene, maleic anhydride-graft-polypropylene; and maleic anhydride-graft-polystyrene.

7. The material according to claim 4 , wherein said entanglement is surface treated with glycosaminoglycan.

8. The material according to claim 2 , wherein: said functionalized polyolefin comprises a polyolefin backbone to which the anhydride functional groups have been grafted; and said entanglement, after performing said hydrolysis reaction, having also been: (a) doped with a host-material crosslinking agent and an antioxidant; (b) surface treated using glycosaminoglycan; and (c) crosslinked, using poly(diisocyanate), to crosslink at least a portion of said guest compound with itself.

9. The material according to claim 8 , molded while at least a portion of said host and said co-host are being crosslinked using said host-material crosslinking agent.

10. The material according to claim 9 , wherein said host-material crosslinking agent is selected from the group consisting of silanes and peroxides.

11. The material according to claim 1 , wherein said hydrophilic outer surface of said outer layer is selected from the group consisting of: a bearing surface adapted for mechanical wear; a flexible barrier surface separating a first and second area; a transparent member surface; an in vivo implant surface; a drag reduction surface; a reaction resin surface; a topical dressing surface; and a dental splint surface.

12. The material according to claim 1 , wherein said polyolefin which has been functionalized with anhydride functional groups comprises a polyolefin backbone into which the anhydride functional groups have been incorporated.

13. The material according to claim 12 , wherein said hydrophilic outer surface of said outer layer is selected from the group consisting of: a bearing surface adapted for mechanical wear; a flexible barrier surface separating a first and second area; a transparent member surface; an in vivo implant surface; a drag reduction surface; a reaction resin surface; a topical dressing surface; and a dental splint surface.

14. A medical device comprising the material according to claim 1 .

Assignees

• Univ Colorado State Res Found

Inventors

• James Susan P
• Zhang Min
• Beauregard Guy
• Oldinski Rachael Kurkowski

Classifications

• C08J9/42

  with macromolecular compounds · CPC title

• C08B37/0072

  Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates · CPC title

• Y10T428/249953

  Composite having voids in a component [e.g., porous, cellular, etc.] · CPC title

• A61L31/048

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title

• C08B37/00

  Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof (cellulose D21; {microbiological processes C12P}) · CPC title