Medical glass element

Patent metadata

Field	Value
Publication number	US-10434224-B2
Application number	US-201815862840-A
Country	US
Kind code	B2
Filing date	Jan 5, 2018
Priority date	Sep 22, 2015
Publication date	Oct 8, 2019
Grant date	Oct 8, 2019

Abstract

A material that is less populated by biofilms than known materials and is well tolerated by the body is provided. The material is an element introducible into or attachable on a human or animal body and includes a glass and/or glass ceramic and/or ceramic material at least in some areas thereof, which inhibits the formation of biofilms and/or on which human or animal cells grow if the element is introduced into the human or animal body or attached thereto, wherein the glass and/or glass ceramic material comprises at least: SiO 2 in a range from 60 to 75 wt % and ZnO in a range from 1 to 7 wt %.

First claim

What is claimed is:

1. A structural article, consisting of a unitary, monolithic material capable of inhibiting the formation of biofilms thereon when the structural article is in contact with a human or animal body, the material comprising a glass and/or glass ceramic and/or ceramic that comprises
SiO 2 in a range from 60 to 75 wt %,
R 2 O in a range from 5 to 20 wt %,
RO in a range from 0 to 10 wt %,
Al 2 O 3 in a range from 1 to 6 wt %,
B 2 O 3 in a range from 0 to 10 wt %,
TiO 2 in a range from 0 to 8 wt %,
ZnO in a range from 1 to 7 wt %, and
FeO in a range from 0 to 5 wt %,
wherein R 2 O is an oxide or a combination of oxides selected from the group consisting of Li 2 O, Na 2 O, and K 2 O, and
wherein RO is an oxide or a combination of oxides selected from the group consisting of MgO, CaO, BaO, SrO, and any combinations thereof.

2. The structural article as claimed in claim 1 , wherein the glass and/or glass ceramic and/or ceramic material comprises:
SiO 2 in a range from 60 to 70 wt %,
R 2 O in a range from 5 to 20 wt %,
RO in a range from 0 to 10 wt %,
Al 2 O 3 in a range from 1 to 5 wt %,
B 2 O 3 in a range from 0 to 10 wt %,
TiO 2 in a range from 0 to 8 wt %,
ZnO in a range from 1 to 7 wt %,
FeO in a range from 0 to 5 wt %, and
Na 2 O in a range from 2 to 10 wt %, and/or
K 2 O in a range from 3.5 to 10 wt %.

3. The structural article as claimed in claim 1 , wherein the glass and/or glass ceramic and/or ceramic material comprises:
a content of Ag of less than 0.3 wt %; and/or
a content of P 2 O 5 of less than 0.5 wt %; and/or
a content of F of less than 1 wt %.

4. The structural article as claimed in claim 1 , wherein the structural article is configured to be introduced into the human or animal body.

5. The structural article as claimed in claim 1 , wherein the structural article is configured to be implanted into the human or animal body.

6. The structural article as claimed in claim 1 , wherein the structural article is configured to be attached to the human or animal body.

7. The structural article as claimed in claim 1 , wherein the structural article is selected from the group consisting of an implant, a casing feedthrough of an implant, a vascular support, a stent, a catheter, an artificial heart valve, a casing for a transponder, a casing for a defibrillator, a casing for a pacemaker, a lab-on-chip, and a contact lens.

8. The structural article of a material as claimed in claim 1 , wherein the material comprises
SiO 2 in a range from 62 to 66 wt %,
Al 2 O 3 in a range from 3.8 to 4.5 wt %,
B 2 O 3 in a range from 0 to 10 wt %,
TiO 2 in a range from 3.5 to 4.5 wt %,
ZnO in a range from 5 to 7 wt %,
FeO in a range from 0.001 to 0.005 wt %,
Na 2 O in a range from 5.9 to 6.5 wt %,
K 2 O in a range from 8.3 to 9.1 wt %, and
SeO 2 in a range from 0 to 0.04 wt %.

9. A structural article consisting of a substrate capable of inhibiting the formation of biofilms thereon when introduced into or attached onto a human or animal body, wherein the substrate includes a material of a glass and/or glass ceramic and/or ceramic of:
SiO 2 in a range from 60 to 75 wt %,
R 2 O in a range from 5 to 20 wt %,
RO in a range from 0 to 10 wt %,
Al 2 O 3 in a range from 1 to 6 wt %,
B 2 O 3 in a range from 0 to 10 wt %,
TiO 2 in a range from 0 to 8 wt %,
ZnO in a range from 1 to 7 wt %, and
FeO in a range from 0 to 5 wt %,
wherein R 2 O is an oxide or a combination of oxides selected from the group consisting of Li 2 O, Na 2 O, and K 2 O, and
wherein RO is an oxide or a combination of oxides selected from the group consisting of MgO, CaO, BaO, SrO, and any combinations thereof.

10. The structural article as claimed in claim 9 , wherein the glass and/or glass ceramic and/or ceramic material comprises:
SiO 2 in a range from 60 to 70 wt %,
R 2 O in a range from 5 to 20 wt %,
RO in a range from 0 to 10 wt %,
Al 2 O 3 in a range from 1 to 5 wt %,
B 2 O 3 in a range from 0 to 10 wt %,
TiO 2 in a range from 0 to 8 wt %,
ZnO in a range from 1 to 7 wt %,
FeO in a range from 0 to 5 wt %, and
Na 2 O in a range from 2 to 10 wt %, and/or
K 2 O in a range from 3.5 to 10 wt %.

11. The structural article as claimed in claim 9 , wherein the glass and/or glass ceramic and/or ceramic material comprises:
a content of Ag of less than 0.3 wt %; and/or
a content of P 2 O 5 of less than 0.5 wt %; and/or
a content of F of less than 1 wt %.

12. The structural article as claimed in claim 9 , wherein the structural article is configured to be introduced into the human or animal body.

13. The structural article as claimed in claim 9 , wherein the structural article is configured to be implanted into the human or animal body.

14. The structural article as claimed in claim 9 , wherein the structural article is configured to be attached to the human or animal body.

15. The structural article as claimed in claim 9 , wherein the structural article is selected from the group consisting of an implant, a casing feedthrough of an implant, a vascular support, a stent, a catheter, an artificial heart valve, a casing for a transponder, a casing for a defibrillator, a casing for a pacemaker, a lab-on-chip, and a contact lens.

16. The structural article of a material as claimed in claim 9 , wherein the material comprises
SiO 2 in a range from 62 to 66 wt %,
Al 2 O 3 in a range from 3.8 to 4.5 wt %,
B 2 O 3 in a range from 0 to 10 wt %,
TiO 2 in a range from 3.5 to 4.5 wt %,
ZnO in a range from 5 to 7 wt %,
FeO in a range from 0.001 to 0.005 wt %,
Na 2 O in a range from 5.9 to 6.5 wt %,
K 2 O in a range from 8.3 to 9.1 wt %, and
SeO 2 in a range from 0 to 0.04 wt %.

Assignees

• Schott Ag

Inventors

• Pichler-Wilhelm Sabine
• Makarewicz Oliwia
• Lautenschläger Christian
• Klinger-Strobel Mareike
• Stallmach Andreas
• Pletz Mathias W R

Classifications

• A61L31/14

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L31/088 Primary

  Other specific inorganic materials not covered by A61L31/084 or A61L31/086 · CPC title

• C03C3/093

  containing zinc or zirconium · CPC title

• A61L29/16

  Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)} · CPC title

• C03C8/04

  containing zinc · CPC title