Hyaluronic acid-collagen matrices for dermal filling and volumizing applications

Patent metadata

Field	Value
Publication number	US-10434214-B2
Application number	US-201715727916-A
Country	US
Kind code	B2
Filing date	Oct 9, 2017
Priority date	Sep 6, 2011
Publication date	Oct 8, 2019
Grant date	Oct 8, 2019

Abstract

Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

First claim

What is claimed is:

1. A soft tissue aesthetic product comprising:
an injectable hydrogel composition comprising:
(i) water; and
(ii) a hyaluronic acid crosslinked with a collagen via a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an amide bond; and wherein the hyaluronic acid concentration is from 6 mg/ml to 20 mg/ml; the collagen concentration is from 3 mg/ml to 12 mg/ml; the hyaluronic acid:collagen weight ratio is from 1:1 to 7:1; and the hydrogel has a storage modulus value of between 850 Pa and 5,000 Pa.

2. The product of claim 1 , wherein the product further comprises a label, and wherein the label comprises instructions for injecting the hydrogel composition into a human tissue.

3. The product of claim 1 , wherein the collagen is collagen type I, collagen type Ill, or a combination thereof.

4. The product of claim 3 , wherein the collagen is collagen type I.

5. The product of claim 3 , wherein the collagen is derived from a human or porcine source.

6. The product of claim 1 , wherein the hyaluronic acid has a molecular weight of about 1,000,000 Da to about 5,000,000 Da.

7. The product of claim 1 , wherein the hyaluronic acid has a molecular weight of about 1,000,000 Da to about 3,000,000 Da.

8. The product of claim 1 , wherein the ratio of the hyaluronic acid to the collagen ranges from 1:1 to 2:1.

9. The product of claim 1 , wherein the ratio of the hyaluronic acid to the collagen is 1:1.

10. The product of claim 1 , wherein the hydrogel has a storage modulus value of between 1,000 Pa and 5,000 Pa.

11. The product of claim 1 , wherein the hydrogel has a hyaluronic acid concentration of 12 mg/ml or 16 mg/ml.

12. The product of claim 1 , wherein the hydrogel has a collagen concentration of 6 mg/ml, 8 mg/ml or 12 mg/ml.

13. The product of claim 1 , wherein the hydrogel has a hyaluronic acid concentration of 12 mg/ml and a collagen concentration of 6 mg/ml.

14. The product of claim 1 , wherein the hydrogel has a hyaluronic acid concentration of 12 mg/ml and a collagen concentration of 12 mg/ml.

15. The product of claim 1 , wherein the hydrogel has a hyaluronic acid concentration of 16 mg/ml and a collagen concentration of 8 mg/ml.

16. The product of claim 2 , wherein the injection is intradermal.

17. The product of claim 2 , wherein the injection is subcutaneous.

18. The product of claim 2 , wherein the human tissue contains adipose tissue.

Assignees

• Allergan Inc

Inventors

• Yu Xiaojie
• Manesis Nicholas J
• Pollock Jacob

Classifications

• A61L27/52

  Hydrogels or hydrocolloids · CPC title

• A61K8/042

  Gels · CPC title

• A61Q19/08

  Anti-ageing preparations · CPC title

• A61L27/24 Primary

  Collagen · CPC title

• A61L2430/34

  for soft tissue reconstruction · CPC title