Sterilizing device and sterilization method having energy recovery
US-2015374864-A1 · Dec 31, 2015 · US
Method for continuous virus inactivation
US10434201B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10434201-B2 |
| Application number | US-201615569635-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 25, 2016 |
| Priority date | Apr 28, 2015 |
| Publication date | Oct 8, 2019 |
| Grant date | Oct 8, 2019 |
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Abstract
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The invention provides a method for continuous virus inactivation. The product stream is segmented by introducing a separating medium which is immiscible with the product stream and the segmented product stream is transported into a reactor 1 as detention segment under virus-inactivating conditions for the required detention time.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for continuous virus inactivation of a product stream that is to be inactivated in a reactor having a low hydraulic diameter of 0.01 mm to 6 mm, comprising: a. providing a product stream that is to be inactivated, b. setting a virus-inactivating condition, wherein the virus-inactivating condition comprises a low pH, using a detergent, or UV or thermal treatment, c. introducing a separating medium that is immiscible with the product stream into the product stream to segment the product stream, d. feeding and passaging the segmented product stream from c) under the virus-inactivating condition through a detention segment formed by the reactor, e. outflowing the segmented product stream from the detention segment. 2. A method according to claim 1 , wherein, in b), the pH of the product stream is set to ≤4, provided that the pH of the product stream that is to be inactivated does not already have the required set pH. 3. A method according to claim 1 , wherein the product stream that is to be inactivated is a solution of macromolecules. 4. A method according to claim 1 , further comprising a step f), wherein, in f), the separating medium is separated off continuously. 5. A method according to claim 1 , wherein the reactor has a hydraulic diameter of 0.5 mm to 3 mm. 6. A method according to claim 1 , wherein the product stream that is to be inactivated is a protein or peptide solution. 7. A method according to claim 1 , wherein the product stream that is to be inactivated is an antibody solution. 8. A method according to claim 1 , wherein the virus-inactivating condition is a low pH of ≤4. 9. A method according to claim 1 , wherein the virus-inactivating condition is using a detergent. 10. A method according to claim 1 , wherein the virus-inactivating condition is UV or thermal treatment.
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Frequently asked questions
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- What does patent US10434201B2 cover?
- The invention provides a method for continuous virus inactivation. The product stream is segmented by introducing a separating medium which is immiscible with the product stream and the segmented product stream is transported into a reactor 1 as detention segment under virus-inactivating conditions for the required detention time.
- Who is the assignee on this patent?
- Bayer Ag
- What technology area does this patent fall under?
- Primary CPC classification A61L2/04. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).