Powerful MHC-class II peptides derived from survivin

Patent metadata

Field	Value
Publication number	US-10434136-B2
Application number	US-201313931413-A
Country	US
Kind code	B2
Filing date	Jun 28, 2013
Priority date	May 14, 2008
Publication date	Oct 8, 2019
Grant date	Oct 8, 2019

Abstract

The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention specifically relates to three novel peptide sequences and variants thereof derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.

First claim

The invention claimed is:

1. A pharmaceutical composition comprising a single peptide consisting of the amino acid sequence of TLGEFLKLDRERAKD (SEQ ID NO:3) and an immunologically effective amount of an adjuvant.

2. A kit, comprising:
(a) a container that contains the pharmaceutical composition according to claim 1 in solution or in lyophilized form;
(b) optionally, a second container containing a diluent or reconstituting solution for the lyophilized formulation; and
(c) optionally, instructions for the use of the solution and/or the reconstitution and/or use of the lyophilized formulation.

3. A pharmaceutical composition comprising a single peptide consisting essentially of a peptide consisting of the amino acid sequence of TLGEFLKLDRERAKD (SEQ ID NO:3) and an immunologically effective amount of an adjuvant.

Assignees

• Immatics Biotechnologies Gmbh

Inventors

• Rammensee Hans-Georg
• Stevanovic Stefan
• Gouttefangeas Cecile
• Weinschenk Toni
• Lewandrowski Peter

Classifications

• A61P35/02

  specific for leukemia · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• C07K7/08

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title

• C12N15/10

  Processes for the isolation, preparation or purification of DNA or RNA (chemical preparation of DNA or RNA C07H21/00; preparation of non-structural polynucleotides from microorganisms or with enzymes C12P19/34) · CPC title

• A61K38/10 Primary

  Peptides having 12 to 20 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title