Antimicrobial substrate surface

Patent metadata

Field	Value
Publication number	US-10433542-B2
Application number	US-201815871190-A
Country	US
Kind code	B2
Filing date	Jan 15, 2018
Priority date	Jan 31, 2017
Publication date	Oct 8, 2019
Grant date	Oct 8, 2019

Abstract

Embodiments described herein include an antimicrobial substrate surface. An example embodiment includes a structure that includes an antimicrobial surface on a substrate. The antimicrobial surface includes a plurality of nanostructures. Each nanostructure includes a nanopillar on the substrate. The nanopillar has a height. Each nanostructure also includes a head covering a distal end and at least part of the height of the nanopillar.

First claim

What is claimed is:

1. A structure comprising an antimicrobial surface on a substrate, wherein the antimicrobial surface comprises a plurality of nanostructures, and wherein each nanostructure comprises:
a nanopillar on the substrate, wherein the nanopillar has a height; and
a head covering a distal end and at least part of the height of the nanopillar;
wherein each of the heads covers only a part of the height of the respective nanopillar, thereby forming a nanopillar portion not covered by the head,
wherein the nanopillar portions not covered by the heads have an average width,
wherein the heads have a width and a height,
wherein the widths of the heads are larger than the average width of the nanopillar portions not covered by the heads, and
wherein the ratio of head width to head height is from about 0.7 to about 1.3.

2. The structure according to claim 1 , wherein the head is round, spherical, spheroidal, ellipsoidal, or rectangular.

3. The structure according to claim 1 , wherein the antimicrobial surface is synthetic.

4. The structure according to claim 1 ,
wherein the antimicrobial surface comprises an antimicrobial property, and
wherein the antimicrobial property of the antimicrobial surface is biophysical in nature.

5. The structure according to claim 1 , wherein distances between corresponding points of two adjacent nanopillars of two adjacent nanostructures of the plurality of nanostructures is, on average, between 20 nm and 500 nm.

6. The structure according to claim 1 , wherein an average width among the nanopillars of the plurality of nanostructures is between 10 nm and 300 nm.

7. The structure according to claim 1 , wherein the height of each of the nanopillars is between 10 nm and 840 nm.

8. The structure according to claim 1 ,
wherein the head has a width, and
wherein the width of the head is between 40 nm and 510 nm.

9. The structure according to claim 1 , wherein each of the nanopillar portions not covered by the heads are capable of flexing to an extent that heads of adjacent nanostructures within the plurality of nanostructures can touch each other.

10. The structure according to claim 1 , wherein the structure is usable to kill or inhibit growth of a microorganism.

11. The structure according to claim 10 , wherein the microorganism is a bacterium, a virus, or a fungus.

12. The structure according to claim 10 ,
wherein the antimicrobial surface comprises gaps defined between the heads of adjacent nanostructures,
wherein the gaps each have a width, measured parallel to the substrate at least one position along a height of the gaps, of between 2 nm and 40 nm, and
wherein the gaps each have a depth measured from the at least one position along the height of the gaps to the substrate of at least 10 nm.

13. The structure according to claim 1 ,
wherein the heads of the nanostructures are nanoparticles,
wherein the nanoparticles have a width of between 20 nm and 400 nm,
wherein the nanoparticles are packed in such a way that gaps exist in the antimicrobial surface, between the nanoparticles,
wherein the gaps are between 2 nm and 400 nm,
wherein the structure further comprises a coating layer covering the nanoparticles, and
wherein the coating layer is thinner than the width of the nanoparticles.

14. The structure according to claim 13 , wherein the coating layer is thinner than half of the width of the nanoparticles.

15. A method for making a structure comprising an antimicrobial surface on a substrate, comprising:
providing a substrate with a plurality of nanopillars thereon, wherein each nanopillar has a height; and
forming a head at a distal end of each nanopillar, wherein each head covers the distal end and at least part of the height of the respective nanopillar on which it is formed,
wherein each of the heads covers only a part of the height of the respective nanopillar, thereby forming a nanopillar portion not covered by the head,
wherein the nanopillar portions not covered by the heads have an average width,
wherein the heads have a width and a height,
wherein the widths of the heads are larger than the average width of the nanopillar portions not covered by the heads, and
wherein the ratio of head width to head height is from about 0.7 to about 1.3.

16. The method according to claim 15 ,
wherein each head only covers part of the height of the respective nanopillar on which it is formed, thereby defining a respective nanopillar portion that is not covered by the head, and
wherein each head has a width that is larger than an average width of the respective nanopillar portion.

17. The method according to claim 15 , wherein providing the substrate with the plurality of nanopillars thereon comprises:
phase separating a layer of a block copolymer into a cylindrical phase and a non-cylindrical phase; and
removing the non-cylindrical phase, thereby forming the plurality of nanopillars.

18. A method for making a structure comprising an antimicrobial surface on a substrate, comprising:
providing a mold for a plurality of nanostructures, comprising:
a substrate-shaped cavity; and
a plurality of nanostructure-shaped cavities opening therein, wherein each nanostructure-shaped cavity comprises:
a nanopillar-shaped portion; and
a head portion on a distal end of the nanopillar-shaped portion,
wherein the head portion has a width and a height, and the nanopillar portion has an average width,
wherein the width of the head portion is larger than the average width of the nanopillar portion, and
wherein the ratio of head width to head height is from about 0.7 to about 1.3;

filling the mold with a precursor material; and
removing the mold from the precursor material.

19. The method according to claim 18 , further comprising hardening the precursor material prior to removing the mold from the precursor material.

Assignees

• Imec Vzw

Inventors

• Xu Xiumei

Classifications

• H10P50/242

  of Group IV materials · CPC title

• B81B2207/056

  of static structures · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• B81B2203/0361

  Tips, pillars · CPC title

• A01N25/34 Primary

  Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group · CPC title