Simultaneous dynamic contrast enhanced and dynamic susceptibility magnetic resonance imaging using magnetic resonance fingerprinting

Patent metadata

Field	Value
Publication number	US-10429468-B2
Application number	US-201715464456-A
Country	US
Kind code	B2
Filing date	Mar 21, 2017
Priority date	Mar 25, 2016
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

Quantitative perfusion parameter maps can be generated based on multiple different relaxation parameter maps that are simultaneously produced from images acquired using contrast-enhanced magnetic resonance imaging (“MRI”) techniques.

First claim

The invention claimed is:

1. A method for using a magnetic resonance imaging (MRI) system to estimate quantitative perfusion parameters of a subject that has been administered a contrast agent, the steps of the method comprising:
(a) estimating optimized acquisition parameters that are optimized to direct the MRI system to generate a plurality of different signal evolutions that maximize discrimination between different magnetic resonance relaxation parameters in a minimized number of repetition time (TR) periods;
(b) acquiring contrast-enhanced data with the MRI system by directing the MRI system to perform a plurality of pulse sequences using the optimized acquisition parameters, the acquired contrast-enhanced data representing the plurality of different signal evolutions;
(c) simultaneously estimating longitudinal relaxation parameters and transverse relaxation parameters by comparing the acquired contrast-enhanced data with a dictionary database comprising a plurality of different signal evolution templates; and
(d) computing quantitative perfusion parameters based on the longitudinal relaxation parameters and the transverse relaxation parameters.

2. The method as recited in claim 1 , wherein the longitudinal relaxation parameters include at least one of longitudinal relaxation time (T1) or longitudinal relaxation rate (R1), and the transverse relaxation parameters include at least one of transverse relaxation time (T2), transverse relaxation rate (R2), apparent transverse relaxation time (T2*), or apparent transverse relaxation rate (R2*).

3. The method as recited in claim 1 , wherein step (d) includes computing at least one of blood volume, blood flow, or mean transit time.

4. The method as recited in claim 3 , wherein the blood volume is a cerebral blood volume and the blood flow is a cerebral blood flow.

5. The method as recited in claim 1 , wherein step (d) includes using pharmacokinetic modeling to compute at least one of transfer coefficient (K trans ) or area under the curve (AUC).

6. The method as recited in claim 1 , wherein step (b) includes acquiring the contrast-enhanced data using an echo-planar imaging (EPI) pulse sequence that samples k-space during each of a plurality of different TR periods and such that the contrast-enhanced data acquired during each TR period represents a plurality of different signal evolutions acquired using different acquisition parameter settings.

7. The method as recited in claim 6 , wherein the EPI pulse sequence samples k-space along a Cartesian trajectory.

8. The method as recited in claim 6 , wherein the EPI pulse sequence samples k-space by undersampling k-space.

9. The method as recited in claim 6 , wherein the EPI pulse sequence is a spin-echo EPI pulse sequence.

10. A magnetic resonance imaging (MRI) system, comprising:
a magnet system that generates a polarizing magnetic field about at least a portion of a subject arranged in the magnet system;
a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field along each of at least three directions;
a radio frequency (RF) system configured to apply an excitation field to the subject and acquire magnetic resonance data therefrom;
a computer system programmed to:
estimate optimized acquisition parameters that are optimized to direct the plurality of gradient coils and the RF system to generate a plurality of different signal evolutions that maximize discrimination between different magnetic resonance relaxation parameters in a minimized number of repetition time (TR) periods;
direct the plurality of gradient coils and the RF system to perform a plurality of pulse sequences using the optimized acquisition parameters in order to acquire contrast-enhanced data that represents the plurality of different signal evolutions; and
simultaneously estimate longitudinal relaxation parameters and transverse relaxation parameters by comparing the acquired contrast-enhanced data with a dictionary database comprising a plurality of different signal evolution templates; and
compute quantitative perfusion parameters based on the longitudinal relaxation parameters and the transverse relaxation parameters.

11. The MRI system as recited in claim 10 , wherein the computer system estimates the longitudinal relaxation parameters as at least one of longitudinal relaxation time (T1) or longitudinal relaxation rate (R1), and the computer system estimates the transverse relaxation parameters as at least one of transverse relaxation time (T2), transverse relaxation rate (R2), apparent transverse relaxation time (T2*), or apparent transverse relaxation rate (R2*).

12. The MRI system as recited in claim 10 , wherein the computer system is programmed to compute the quantitative perfusion parameters as one of at least blood volume, blood flow, or mean transit time.

13. The MRI system as recited in claim 12 , wherein the computer system is programmed to compute the blood volume as a cerebral blood volume and to compute the blood flow as a cerebral blood flow.

14. The MRI system as recited in claim 10 , wherein the computer system is programmed to compute the quantitative perfusion parameters using pharmacokinetic modeling to compute at least one of transfer coefficient (K trans ) or area under the curve (AUC).

15. The MRI system as recited in claim 10 , wherein the computer system is programmed to direct the plurality of gradient coils and the RF system to perform the plurality of pulse sequences as echo-planar imaging (EPI) pulse sequences that sample k-space during each of a plurality of different TR periods and such that the contrast-enhanced data acquired during each TR period represents a plurality of different signal evolutions acquired using different acquisition parameter settings.

16. The MRI system as recited in claim 15 , wherein the computer system is programmed to direct the plurality of gradient coils and the RF system to perform the plurality of pulse sequences as echo-planar imaging (EPI) pulse sequences that sample k-space along a Cartesian trajectory.

17. The MRI system as recited in claim 15 , wherein the computer system is programmed to direct the plurality of gradient coils and the RF system to perform the plurality of pulse sequences as echo-planar imaging (EPI) pulse sequences that undersample k-space.

18. The MRI system as recited in claim 16 , wherein the computer system is programmed to direct the plurality of gradient coils and the RF system to perform the plurality of pulse sequences as echo-planar imaging (EPI) pulse sequences that are spin-echo EPI pulse sequences.

Assignees

• Massachusetts Gen Hospital

Inventors

• Cohen Ouri

Classifications

• G01R33/4806 Primary

  Functional imaging of brain activation · CPC title

• G01R33/5601

  involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent · CPC title

• G01R33/50

  based on the determination of relaxation times {, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences} · CPC title

• G01R33/56366

  Perfusion imaging · CPC title

• G01R33/482

  using a Cartesian trajectory · CPC title