Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain

Patent metadata

Field	Value
Publication number	US-10428115-B2
Application number	US-201414893800-A
Country	US
Kind code	B2
Filing date	May 23, 2014
Priority date	May 24, 2013
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

Described are Dynorphin A analog compounds and uses thereof for treating pain in humans and lower animals by administering to a human or lower animal in need of treatment. The compounds interact with the bradykinin receptor to relieve pain. Preferred compounds are amphipathic [Des-Arg7]-dynorphin A peptide analogs and specific cyclic dynorphin A peptide analogs.

First claim

The invention claimed is:

1. A peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 4-6, 28, 30, 33, 34, and 36-45.

2. The peptide of claim 1 , wherein said peptide is selected from the group consisting of SEQ ID NOs: 4, 5, 28, 33, 34, and 37-42.

3. A pharmaceutical composition comprising a peptide of claim 1 or a pharmaceutically acceptable salt thereof.

4. The pharmaceutical composition of claim 3 , wherein said pharmaceutical composition further comprises a pharmaceutically acceptable carrier.

5. A method for treating pain in a subject, said method comprising administering to a subject in need of pain treatment a peptide of claim 1 .

6. The method of claim 5 , wherein said peptide is administered 1 to 4 times per day, with a total dose of 0.1 to 30.0 mg/kg.

7. The method of claim 5 , wherein the pain is selected from the group consisting of nociceptive pain, somatic pain, visceral pain, neuropathic pain, pain syndrome, pain associated with diabetic neuropathy, trigeminal neuralgia, postherpetic neuralgia, post-stroke pain, complex regional pain syndrome, reflex sympathetic dystrophy, causalgia, psychogenic pain, or a combination thereof.

8. A peptide consisting of the amino acid sequence of SEQ ID NO: 46.

Assignees

• Univ Arizona

Inventors

• Lee Yeon Sun
• Hruby Victor J
• Porreca Frank
• Lai Josephine

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title

• C07K14/665 Primary

  derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• C07K7/08

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title