5′-substituted nucleoside compounds
US-9840532-B2 · Dec 12, 2017 · US
Substituted nucleoside derivatives useful as anticancer agents
US10428104B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10428104-B2 |
| Application number | US-201615045679-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 17, 2016 |
| Priority date | Feb 24, 2015 |
| Publication date | Oct 1, 2019 |
| Grant date | Oct 1, 2019 |
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Abstract
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Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.
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A compound selected from: (2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(4-fluoro-3-methylphenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(3-chloro-4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(4-fluoro-3-methoxyphenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, 5-((R)-((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-2-yl)(hydroxy)methyl)-2-fluorobenzonitrile, (2R,3S,4R,5R)-2-((R)-(2-(dimethylamino)pyridin-4-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-indazol-6-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-hydroxy(3-(trifluoromethyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (3S,4R,5R)-2-((3-fluoro-5-(trifluoromethyl)phenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(4-fluoro-3-(trifluoromethyl)phenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-hydroxy(3-(methylsulfonyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-hydroxy(4-(methylsulfonyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(3-(difluoromethyl)benzofuran-5-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(1-(difluoromethyl)-1H-benzo[d]imidazol-6-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(1-(difluoromethyl)-1H-benzo[d]imidazol-5-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2S,3S,4R,5R)-2-((R)-1-hydroxy-2-(phenylsulfonyl)ethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-indol-6-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-1-hydroxy-2-phenylethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2((S)-1-hydroxy-2-phenylethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-1-hydroxy-3-phenylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-1-hydroxy-3-phenylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(3-chlorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-(3-chlorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(3-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(3,5-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-(3,5-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-1-hydroxypropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-1-hydroxypropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-cyclopentyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-cyclopentyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-cyclopropyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-cyclopropyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-1-hydroxy-2-methylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-1-hydroxy-2-methylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-hydroxy(1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((R)-cyclobutyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((S)-cyclobutyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2S,3S,4R,5R)-2-((S)-furan-2-yl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2S,3S,4R,5R)-2-((R)-furan-2-yl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)tetrahydrofuran-3,4-diol, (2R,3S,4R,5R)-2-((1H-pyrazol-1-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (3S,4R,5R)-2-(difluoro(4-fluorophenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-hydroxypropyl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-hydroxybutyl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol, (2R,3R,4S,5S)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol, (2R,3R,4S,5S)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol, (2R,3R,4S,5R)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(oxazol-5-yl)tetrahydrofuran-3,4-diol, (2S,3S,4R,5R)-2-((R)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2S,3S,4R,5R)-2-(hydroxymethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol, (2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(1H-pyrazol-5-yl)tetrahydro
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- What does patent US10428104B2 cover?
- Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.
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- Pfizer
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- Primary CPC classification C07H19/14. Mapped technology areas include Chemistry & Metallurgy.
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- Publication date Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
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