Guanidine-functionalized perlite particles, articles containing the particles, and methods of using the particles and articles

Patent metadata

Field	Value
Publication number	US-10427131-B2
Application number	US-201615555679-A
Country	US
Kind code	B2
Filing date	Mar 15, 2016
Priority date	Mar 19, 2015
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

Guanidine-functionalized perlite particles are provided. Nonwoven articles are also provided, including a fibrous porous matrix and guanidine-functionalized perlite particles enmeshed in the fibrous porous matrix. Laminated articles are additionally provided, including a first substrate and a second substrate sealed to the first substrate along at least a portion of a perimeter of the first substrate. The laminated article further includes guanidine-functionalized perlite particles disposed between the first substrate and the second substrate. Methods of detecting microorganisms or target cellular analytes in a fluid sample using guanidine-functionalized particles or laminated articles are also provided.

First claim

What is claimed is:

1. A guanidine-functionalized perlite particle comprising a perlite particle that is modified with at least one silane having the formula
X 3-n R a n Si—Y-G,

wherein:
n is 0, 1, or 2;
each R a , if present, is independently an alkyl, aralkyl, or aryl;
Y is a divalent group comprising an alkylene having 2 to 20 carbons;
G is a guanidine group of the formula —NH—C(═NH)—NH 2 ; and
each X is independently alkoxy or acyloxy.

2. The guanidine-functionalized perlite particle of claim 1 , wherein the divalent group further comprises an arylene, oxy, —NH—, or a combination thereof.

3. The guanidine-functionalized perlite particle of claim 1 , wherein the divalent group is alkylene having 3 to 6 carbons.

4. The guanidine-functionalized perlite particle of claim 1 , wherein the guanidine group is the reaction product of a primary amine and an O-methylisourea salt.

5. The guanidine-functionalized perlite particle of claim 4 , wherein the primary amine is 3-aminopropyltrimethoxysilane.

6. The guanidine-functionalized perlite particle of claim 1 , having a surface nitrogen content of at least 2 atomic percent as measured by x-ray photoelectron spectroscopy (XPS).

7. A nonwoven article comprising a) a fibrous porous matrix and b) a plurality of guanidine-functionalized perlite particles enmeshed in the fibrous porous matrix, and wherein each of the guanidine-functionalized perlite particles comprises a perlite particle that is modified with at least one silane having the formula
X 3-n R a n Si—Y-G,

wherein:
n is 0, 1, or 2;
each R a , if present, is independently an alkyl, aralkyl, or aryl;
Y is a divalent group comprising an alkylene having 2 to 20 carbons;
G is a guanidine group of the formula —NH—C(═NH)—NH 2 ; and
each X is independently alkoxy or acyloxy.

8. The nonwoven article of claim 7 , wherein the fibrous porous matrix has a thickness of between 0.15 millimeters and 2 millimeters.

9. The nonwoven article of claim 7 , wherein the fibrous porous matrix is a nonwoven fibrous layer comprising polymeric fibers and inorganic fibers.

10. The nonwoven article of claim 7 , wherein the fibrous porous matrix is a nonwoven fibrous layer and the guanidine-functionalized perlite particles are distributed throughout the nonwoven fibrous layer.

11. The nonwoven article of claim 7 , wherein the fibrous porous matrix is a nonwoven fibrous layer comprising uncrimped polymeric fibers.

12. A laminated article comprising:
a. a first substrate;
b. a second substrate sealed to the first substrate along at least a portion of a perimeter of the first substrate; and
c. a plurality of guanidine-functionalized perlite particles disposed between the first substrate and the second substrate, wherein each of the guanidine-functionalized perlite particles comprises a perlite particle that is modified with at least one silane having the formula
X 3-n R a n Si—Y-G,

wherein:
n is 0, 1, or 2;
each R a , if present, is independently an alkyl, aralkyl, or aryl;
Y is a divalent group comprising an alkylene having 2 to 20 carbons;
G is a guanidine group of the formula —NH—C(═NH)—NH 2 ; and
each X is independently alkoxy or acyloxy.

13. The laminated article of claim 12 , wherein the first substrate and the second substrate are independently selected from a spunbond polypropylene, a spunbond polyamide, a spunbond blend of polyamide and polyester, a spunbond polyethylene, a spunbond polyester, a spunbond polybutylene terephthalate, and a spunbond polypropylene.

14. A method of detecting microorganisms or target cellular analytes in a fluid sample, the method comprising:
a) providing a laminated article according to claim 12 ;
b) providing a fluid sample suspected of containing at least one microorganism strain or target cellular analyte;
c) contacting the fluid sample with the laminated article such that at least a portion of the at least one microorganism strain or target cellular analyte is bound to the laminated article; and
d) detecting the presence of the at least one bound microorganism strain or bound target cellular analyte.

15. The method of claim 14 , wherein the detecting comprises a bioluminescence method.

16. The method of claim 14 , wherein the bound target cellular analyte comprises a nucleic acid, a protein, a cell wall component, ATP, or a combination thereof.

17. The method of claim 14 , wherein the contacting comprises passing the fluid sample through the laminated article at a pressure of 4.0 pounds per square inch (psi) (27.58 kilopascals (kPa)) or less.

18. A method of detecting microorganisms or target cellular analytes in a fluid sample, the method comprising:
a) providing a plurality of guanidine-functionalized perlite particles according to claim 1 ;
b) providing a fluid sample suspected of containing at least one microorganism strain or target cellular analyte;
c) contacting the fluid sample with the plurality of guanidine-functionalized perlite particles such that at least a portion of the at least one microorganism strain or target cellular analyte is bound to the guanidine-functionalized perlite particles; and
d) detecting the presence of the at least one bound microorganism strain or bound target cellular analyte.

Assignees

• 3M Innovative Properties Co

Inventors

• Kshirsagar Manjiri T
• Griesgraber George W

Classifications

• B01J20/3259

  comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom · CPC title

• B01J20/3204

  Inorganic carriers, supports or substrates · CPC title

• C04B2111/00991

  for testing · CPC title

• G01N33/569

  for microorganisms, e.g. protozoa, bacteria, viruses · CPC title

• G01N33/56916

  Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia · CPC title