Disconnector device

Patent metadata

Field	Value
Publication number	US-10427127-B2
Application number	US-201615547011-A
Country	US
Kind code	B2
Filing date	Mar 16, 2016
Priority date	Mar 16, 2015
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

The present invention relates to an automated radiosynthesis device adapted for enhanced automatic disconnection of a disposable kit once a radiosynthesis has been carried out. The automated radiosynthesis device of the invention therefore reduces the time to remove the disposable kit from the radiosynthesis device and reduces radiation exposure to the operator.

First claim

The invention claimed is:

1. An automated radiosynthesis device comprising:
a plurality of fluidic connectors for removably attaching a disposable kit to said automated radiosynthesis device;
automated attachment means for automated attachment to and removal from said automated radiosynthesis device of said disposable kit;
a disconnector device comprising a rigid substantially planar body defining an aperture therethrough, the disconnector device rigidly attached to the automated attachment means such that movement of the disposable kit away from the from the automated radiosynthesis device disconnects at least one fluidic connector;
a plurality of actuators to selectively control moving parts of said disposable kit;
a control unit for directing the selective control of the moving parts of said disposable kit by said plurality of actuators;
a reaction vessel heating well;
an inert gas conduit;
a vacuum conduit; and
a radioisotope conduit.

2. The automated radiosynthesis device as defined in claim 1 , wherein said fluidic connectors include push-on connectors, luer slip connectors, luer screw connectors, or combinations thereof.

3. The automated radiosynthesis device as defined in claim 2 , wherein the body of the disconnector device includes a fork with arms spaced apart by a distance slightly less than a maximum diameter of a male part of a luer connector.

4. The automated radiosynthesis device as defined in claim 2 , wherein the aperture of the disconnector device has an O-shape with a diameter slightly less than a maximum diameter of a male part of a luer connector.

5. The automated radiosynthesis device as defined in claim 1 , wherein said disposable kit is suitable for the synthesis of a radiotracer compound.

6. The automated radiosynthesis device as defined in claim 1 , wherein said disposable kit is suitable for the synthesis of a 18 F-labelled PET radiotracer compound.

7. The automated radiosynthesis device as defined in claim 1 , wherein said disposable kit is a single-use cassette.

8. The automated radiosynthesis device as defined in claim 1 , wherein said plurality of actuators include rotatable arms for stopcocks of valves, linear actuators, arms that press onto reagent vials, pinch valves, or combinations thereof.

9. The automated radiosynthesis device as defined in claim 1 , wherein said moving parts of said disposable kit include reagent vials, syringes, valves or combinations thereof.

10. The automated radiosynthesis device as defined in claim 1 , wherein said control unit includes software comprising instructions for a particular radiosynthesis method to be carried out on said disposable kit attached to said automated radiosynthesis device.

11. The automated radiosynthesis device as defined in claim 1 , wherein said automated attachment means comprises a drawer into which said disposable kit can be loaded and wherein said drawer is moveable between a first position for loading and/or disconnecting said disposable kit and a second position where said loaded disposable kit is attached to said face of said automated radiosynthesis device.

12. The automated radiosynthesis device as defined as defined in claim 1 , wherein the body of the disconnection device is configured to form rigid arms defining said aperture therebetween.

13. The automated radiosynthesis device as defined in claim 12 , wherein said rigid arms are spaced apart at at least one point along their lengths a distance slightly less than the maximum diameter of a male part of a luer connector.

14. The automated radiosynthesis device as defined in as defined in claim 1 , wherein said disconnector device is made from a metal or a rigid plastic.

15. A radiosynthesis method comprising:
attaching the disposable kit to the automated radiosynthesis device of claim 1 , wherein said disposable kit comprises at least one line having one of said fluidic connectors at the end distal to the disposable kit;
connecting said at least one line to a respective vial;
carrying out a radiosynthesis on said attached disposable kit;
disconnecting said disposable kit following said connecting wherein said disconnecting includes disconnecting said at least one line from its respective vial by means of the disconnector device.

16. The radiosynthesis method as defined in claim 15 , wherein said at least one line is connected to a product collection vial.

17. The radiosynthesis method as defined in claim 15 , wherein said radiosynthesis is the radiosynthesis of a 18 F-labelled compound.

18. The radiosynthesis method as defined in claim 15 , wherein said at least one line is connected to a 18 O-water recovery vial.

19. The radiosynthesis method as defined in claim 17 , wherein said at least one line is connected to a product collection vial.

Assignees

• Ge Healthcare Ltd

Inventors

• Dumont Philippe

Classifications

• B01J19/0093 Primary

  Microreactors, e.g. miniaturised or microfabricated reactors (laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027) · CPC title

• C07B59/00

  Introduction of isotopes of elements into organic compounds {; Labelled organic compounds per se} · CPC title

• B01J2219/00927

  Particle radiation or gamma-radiation · CPC title

• B01J2219/00894

  More than two inlets · CPC title

• B01J2219/00799

  Cup-shaped · CPC title