Drug delivery device with threaded housing and piston, and method for manufacturing the same

Patent metadata

Field	Value
Publication number	US-10426893-B2
Application number	US-201515321998-A
Country	US
Kind code	B2
Filing date	Jul 1, 2015
Priority date	Jul 1, 2014
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing having a tubular portion with an inner thread, a piston rod having a threaded portion and a distal end, and a bearing having a distal face and a proximal face. The bearing includes a retaining stem protruding from the proximal face. The piston rod includes a distal portion having an outer diameter which is smaller than the inner diameter of the inner thread of the tubular portion and comprising at its distal end at least one retaining clip engaging the retaining stem. The axial length of the tubular portion is smaller than or equal to the axial distance between the proximal face of the bearing disc and the distal end of the threaded portion of the piston rod. During manufacturing of the device, the retaining clip engages the retaining stem prior to the inner thread of the tubular portion engages with the threaded portion of the piston rod.

First claim

The invention claimed is:

1. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising: a housing defining a longitudinal axis and having a tubular portion with an inner thread, a piston rod having a threaded portion and a distal end, and a bearing having a distal face and a proximal face, wherein the bearing comprises a retaining stem protruding from the proximal face, wherein the piston rod comprises a distal portion having an outer diameter which is smaller than an inner diameter of the inner thread of the tubular portion, and, a retaining clip engaging the retaining stem at a distal end of the piston rod, and wherein an axial length of the tubular portion is smaller than or equal to an axial distance between the proximal face of the bearing and the distal end of the threaded portion of the piston rod.

2. The drug delivery device according to claim 1 , wherein the tubular portion extends between its distal end and a proximal side of the inner thread.

3. The drug delivery device according to claim 1 , wherein the distal portion of the piston rod has a cylindrical outer surface.

4. The drug delivery device according to claim 1 , wherein the retaining clip comprises a distally extending clip arm located at the distal end of the piston rod defining an insertion space for receiving the retaining stem.

5. The drug delivery device according to claim 1 , wherein internal faces of the retaining clip subtend a total angle between 150° and 190° about the longitudinal axis of the piston rod.

6. The drug delivery device according to claim 1 , wherein a first convex contact surface is provided on one of the retaining stem and the retaining clip and a second contact surface is provided on the other of the retaining stem and the retaining clip, and wherein a radius of curvature of the first convex contact surface is smaller than a radius of curvature of the second contact surface.

7. The drug delivery device according to claim 1 , further comprising
a dose setting member rotatable relative to the housing during dose setting,
a drive member rotationally constrained to the piston rod and rotationally constrained to the housing in a first dose setting mode and rotatable relative to the housing in a second dose dispensing mode,
an actuation button movable relative to the housing in a direction parallel to the longitudinal axis between a first dose setting position and a second dose dispensing position for switching the drug delivery device between the first dose setting mode and the second dose dispensing mode, and
a ratchet for transmitting torque from the dose setting member to the drive member during dose dispensing and allowing relative rotational movement between the dose setting member and the drive member during dose setting, the ratchet comprising first ratchet features rotationally constrained to the drive member and second ratchet features rotationally constrained to the dose setting member.

8. The drug delivery device according to claim 7 , wherein the first ratchet features and the second ratchet features comprise teeth having a ramp angles allowing to overhaul the ratchet for dose correction.

9. The drug delivery device according to claim 7 , wherein the housing has a first aperture or window, and the drug delivery device further comprises
a dose indicator positioned within the housing and rotatable with respect to the housing during dose setting and during dose dispensing,
a gauge element interposed between the housing and the dose indicator, wherein the gauge element has a second aperture or window positioned with respect to the first aperture or window of the housing such that at least a part of the dose indicator is visible through the first and second apertures or windows, and wherein the gauge element is axially guided within the housing and in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element, and
a resilient member adapted to provide a force necessary for ejecting a dose from the drug delivery device.

10. The drug delivery device according to claim 9 , wherein the resilient member is a torsion spring which is strained during dose setting.

11. The drug delivery device according to claim 9 , further comprising a second clutch configured to rotationally couple the actuation button to the dose indicator when the actuation button is in the first dose setting position and configured to de-couple the actuation button from the dose indicator when the actuation button is in the second dose dispensing position.

12. The drug delivery device according to claim 1 , comprising a limiter mechanism defining a maximum settable dose and a minimum settable dose and/or a last dose protection mechanism for preventing the setting of a dose exceeding an amount of liquid left in a cartridge.

13. The drug delivery device according to claim 1 , further comprising a cartridge containing a medicament.

Assignees

• Sanofi Sa

Inventors

• Marsh William
• Morris Anthony Paul

Classifications

• A61M5/31541

  Means preventing setting of a dose beyond the amount remaining in the cartridge · CPC title

• A61M5/31553 Primary

  without axial movement of dose setting member · CPC title

• A61M2205/582

  by tactile feedback · CPC title

• A61M5/20

  Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 {, A61M5/46} take precedence; {hypodermic projectiles F42B12/54}) · CPC title

• A61M5/31515

  Connection of piston with piston rod · CPC title