Expansible cardiovascular graft system

Patent metadata

Field	Value
Publication number	US-10426593-B2
Application number	US-201615557012-A
Country	US
Kind code	B2
Filing date	Mar 11, 2016
Priority date	Mar 11, 2015
Publication date	Oct 1, 2019
Grant date	Oct 1, 2019

Abstract

An expansible cardiovascular graft system for replacing vasculature such as a portion of the aorta. The portion of the aorta may include but is not limited to the ascending aorta, the aortic arch, or the descending aorta. The system features a graft conduit with a proximal anchor disposed at the proximal end and a distal anchor disposed at the distal end and an expansible portion disposed between the proximal anchor and the distal anchor. At least a portion of the expansible system is adapted to gradually expand.

First claim

What is claimed is:

1. An expansible cardiovascular graft system ( 100 ) comprising: a graft conduit ( 110 ) having a proximal end ( 111 ) and a distal end ( 112 ) and having corrugations ( 200 ) stacked from the proximal end ( 111 ) to the distal end ( 112 ), wherein a proximal anchor ( 121 ) is disposed at the proximal end ( 111 ) of the graft conduit ( 110 ) and an inner edge ( 121 a ) of the proximal anchor ( 121 ) comprises serrations ( 125 ) that cut across the stacked corrugations ( 200 ) of the graft conduit and a distal anchor ( 122 ) is disposed at the distal end ( 112 ) of the graft conduit ( 110 ) and an inner edge ( 122 a ) of the distal anchor ( 122 ) comprises serrations ( 125 ) that cut across the stacked corrugations ( 200 ) of the graft conduit; and an expansible portion ( 130 ) is disposed between the proximal anchor ( 121 ) and the distal anchor ( 122 ), wherein the serrations allow the expansible portion ( 130 ) to gradually expand in systole and recoil in diastole.

2. The system ( 100 ) of claim 1 , wherein the system ( 100 ) absorbs at least a portion of left ventricular stroke volume in systole.

3. The system ( 100 ) of claim 2 , wherein the system ( 100 ) absorbs at least 5 cc of ventricular stroke volume.

4. The system ( 100 ) of claim 2 , wherein the system ( 100 ) absorbs at least 15 cc of ventricular stroke volume.

5. The system ( 100 ) of claim 1 , wherein the proximal end ( 111 ) and the distal end ( 112 ) of the graft conduit ( 110 ) are rigid or non-compliant.

6. The system ( 100 ) of claim 1 , wherein the proximal anchor ( 121 ), the distal anchor ( 122 ), both the proximal anchor ( 121 ) and distal anchor ( 122 ), or a portion thereof are rigid or non-compliant.

7. The system ( 100 ) of claim 1 , wherein a portion of the proximal anchor ( 121 ), the distal anchor ( 122 ), or both the proximal anchor ( 121 ) and distal anchor ( 122 ) is expansible.

8. The system ( 100 ) of claim 1 , wherein material of the expansible portion ( 130 ) extends a length of the graft conduit ( 110 ).

9. The system ( 100 ) of claim 1 , wherein the proximal anchor ( 121 ) and distal anchor ( 122 ) encase or coat at least a portion of the expansible portion ( 130 ).

10. The system ( 100 ) of claim 1 , wherein the expansible portion comprises a plurality of expansible portion segments to form a gradient of elasticity.

11. The system ( 100 ) of claim 1 , wherein the proximal anchor ( 121 ) and distal anchor ( 122 ) are constructed from a material that is less compliant than that of the expansible portion ( 130 ).

12. The system ( 100 ) of claim 1 , wherein the graft conduit ( 110 ) or a portion thereof is coated.

13. The system ( 100 ) of claim 1 , wherein the graft conduit ( 110 ) or a portion thereof is encased in a secondary tube or conduit.

14. The system ( 100 ) of claim 1 further comprising a catheter ( 140 ), wherein the graft conduit ( 110 ) is disposed inside the catheter ( 140 ).

15. The system ( 100 ) of claim 1 further comprising a catheter ( 140 ), wherein the graft conduit ( 110 ) is integrated into the catheter ( 140 ).

16. The system ( 100 ) of claim 1 further comprising a secondary channel ( 150 ) fluidly connected to the proximal anchor ( 121 ), the distal anchor ( 122 ), the expansible portion ( 130 ), a combination thereof, or a portion thereof.

17. The system ( 100 ) of claim 16 , wherein the secondary channel ( 150 ) comprises an expansible portion ( 150 a ).

18. A method of replacing a portion of a vessel, said method comprising: a) providing an expansible cardiovascular graft system, said system comprises a graft conduit ( 110 ) having a proximal end ( 111 ) and a distal end ( 112 ) and having corrugations ( 200 ) stacked between the proximal end and the distal end, wherein a proximal anchor ( 121 ) is disposed at the proximal end ( 111 ) of the graft conduit ( 110 ) and an inner edge ( 121 a ) of the proximal anchor ( 121 ) comprises serrations that cut across the stacked corrugations ( 200 ) and wherein a distal anchor ( 122 ) is disposed at the distal end ( 112 ) of the graft conduit ( 110 ) and an inner edge ( 122 a ) of the distal anchor ( 122 ) comprises serrations ( 125 ) that cut across the stacked corrugations; and an expansible portion ( 130 ) is disposed between the proximal anchor ( 121 ) and the distal anchor ( 122 ), wherein the serrations allow the expansible portion ( 130 ) to gradually expand in systole and recoil in diastole; b) inserting into the vessel the expansible cardiovascular graft system ( 100 ); and c) suturing the proximal end ( 111 ) of the graft conduit ( 110 ) to a first attachment site of the vessel and suturing the distal end ( 112 ) of the graft conduit ( 110 ) to a second attachment site of the vessel.

19. The method of claim 18 , wherein the vessel includes a portion of the aorta.

20. The method of claim 18 , wherein the first attachment site is a sinotubular junction and the second attachment site is a distal ascending aorta.

Assignees

• Univ Arizona
• Banner Health

Inventors

• Lick Scott D
• Smith Richard G

Classifications

• A61F2210/0076

  multilayered, e.g. laminated structures · CPC title

• A61F2250/0018

  differing in elasticity, stiffness or compressibility · CPC title

• A61F2210/0057

  stretchable · CPC title

• A61F2220/0008

  Fixation appliances for connecting prostheses to the body · CPC title

• A61F2/06 Primary

  Blood vessels · CPC title