System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors
US-9463335-B2 · Oct 11, 2016 · US
US10426427B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10426427-B2 |
| Application number | US-201415102671-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 16, 2014 |
| Priority date | Dec 17, 2013 |
| Publication date | Oct 1, 2019 |
| Grant date | Oct 1, 2019 |
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The invention relates to a system ( 10 ) for providing an object ( 2 ) in a body ( 1 ), a processor ( 18 ) arranged to be used in the system ( 10 ) for providing an object ( 2 ) in a body ( 1 ), an instrument ( 12 ) for providing an object ( 2 ) into a body ( 1 ), a method for detecting a providing of an object ( 2 ) in a body ( 1 ) and a software product for detecting a providing of an object ( 2 ) in a body ( 1 ). In order to allow for a providing of an object ( 2 ) in a body ( 1 ) and a detecting hereof while avoiding the drawbacks on the known approaches, e.g. giving an opportunity for reliable localization in ultrasound images used for real-time monitoring of a medical procedure with reduced error proneness to electromagnetic interference, the invention utilizes the finding that the characteristics of a reception or transmission of an ultrasound transducer ( 24, 26 ) are influenced by the surrounding environment of the ultrasound transducer ( 24, 26 ). By detecting changes in the characteristics the presence or absence of an object ( 2 ) to be provided at the ultrasound transducer ( 24, 26 ) is determined.
Opening claim text (preview).
The invention claimed is: 1. A system for providing an object in a body, comprising: an ultrasound probe for monitoring an area of the body in which the object is to be provided; an instrument for providing the object in the body, the instrument comprising one or more ultrasound transducers which are arranged such that a reception characteristic for receiving an ultrasound transmission from the ultrasound probe and/or a transmission characteristic for transmitting an ultrasound transmission to the ultrasound probe changes with a presence of the object to be provided in a portion of the instrument and/or a passing of the object to be provided into and/or from the portion of the instrument; and a processor arranged to be used in a system for providing an object in a body, wherein the processor is arranged to determine, based on a signal output of one or more ultrasound transducers of an instrument for providing the object in the body which are arranged such that a reception characteristic for receiving an ultrasound transmission from an ultrasound probe changes with a presence of the object to be provided in a portion of the instrument or a passing of the object to be provided into or from the portion of the instrument, or based on a signal output of an ultrasound probe for monitoring an area of the body in which the object is to be provided, the signal output being in response to an ultrasound transmission from one or more ultrasound transducers of the instrument for providing the object in the body which are arranged such that a transmission characteristic for transmitting an ultrasound transmission to the ultrasound probe changes with a presence of the object to be provided in a portion of the instrument or a passing of the object to be provided into or from the portion of the instrument, without regard to an object to be provided by the instrument being present in the portion of the instrument or passing into or from the portion of the instrument, wherein; the processor is arranged to determine, based on a signal output of the one or more ultrasound transducers or the ultrasound probe, if, at least, an object to be provided by the instrument is present in the portion of the instrument or passing into or from the portion of the instrument; and to determine a position of the instrument relative to the ultrasound probe based on the signal output of the one or more ultrasound transducers and information on the ultrasound transmission of the ultrasound probe, or based on information on the ultrasound transmission of the one or more ultrasound transducers and the signal output of the ultrasound probe, wherein the system is arranged for providing multiple objects by delivering the objects to respective positions in the body, further comprising a delivery management circuit arranged to store delivery positions of the objects based on the determination of the processor. 2. The system according to claim 1 wherein the delivery management circuit is provided with a mapping for positions for the objects to be delivered to and is arranged to modify the mapping for objects to be delivered based on stored delivery positions of delivered objects in order for an overall delivery distribution to conform to a predetermined condition. 3. The system according to claim 2 , wherein the objects to be delivered are radiation sources and the delivery management circuit is arranged to compute a radiation dose based on delivery positions of delivered radiation sources and the mapping of radiation sources to be delivered and to modify the mapping for one or more radiation sources to be delivered in case the computed radiation dose does not fall into a predetermined range. 4. The system according to claim 1 , wherein the one or more ultrasound transducers are formed to enclose one or more portions of the instrument. 5. The system according to claim 1 , wherein at least one of the one or more ultrasound transducers includes a piezoelectric material based on a lead zirconate titanate material, a polyvinlyidene fluoride-trifluoroethylene-copolymer or a polyvinlyidene fluoride-tetrafluoroethylene-copolymer, in particular a piezoelectric material obtained by a sol-gel technique or a capacitive micromachined ultrasonic transducer or a fiber optic hydrophone. 6. The system according to claim 1 , wherein the instrument is arranged for removably providing the object at a predetermined position inside the instrument, wherein a first one of the one or more ultrasound transducers is arranged at the position inside the instrument to which the object is to be provided. 7. A system for providing an object in a body, wherein the object is a radiation source for radiation therapy and the system comprises: an ultrasound probe for monitoring an area of the body in which the object is to be provided; an instrument for providing the object in the body , the instrument comprising one or more ultrasound transducers, which are arranged such that a reception characteristic for receiving an ultrasound transmission from the ultrasound probe or a transmission characteristic for transmitting an ultrasound transmission to the ultrasound probe changes with a presence of the object to be provided in a portion of the instrument or a passing of the object to be provided into or from the portion of the instrument; and a processor arranged to determine, based on a signal output of one or more ultrasound transducers of an instrument for providing the object in the body, which are arranged such that a reception characteristic for receiving an ultrasound transmission from an ultrasound probe for monitoring an area of the body, in which the object is to be provided, changes with a presence of the object to be provided in a portion of the instrument or a passing of the object to be provided into or from the portion of the instrument, or based on the signal output of an ultrasound probe for monitoring an area of the body in which the object is to be provided, the signal output being in response to an ultrasound transmission from one or more ultrasound transducers of the instrument for providing the object in the body, the one or more ultrasonics transducer being arranged such that a transmission characteristic for transmitting an ultrasound transmission to the ultrasound probe changes with a presence of the object to be provided in a portion of the instrument and/or a passing of the object to be provided into and/or from the portion of the instrument, without regard to an object to be provided by the instrument being present in the portion of the instrument or passing into or from the portion of the instrument, wherein: the instrument is arranged for delivering the object into the body through a tip of the instrument; a first one of the one or more ultrasound transducers is arranged at a distance to the tip of the instrument, the distance being less than a length of the object to be delivered; and a second one of the one or more ultrasound transducers is arranged at a distance to the first one which is larger than the length of the object to be delivered. 8. The system according to claim 7 , wherein the processor is arranged to determine a position of the instrument relative to the ultrasound probe, based on the signal output of the one or more ultrasound transducers and information on the ultrasound transmission of the ultrasound probe and/or based on information on the ultrasound transmission of the one or more ultrasound transducers and the signal output of the ultrasound probe, wherein the system is arranged for providing multiple objects by delivering the objects to respective positions in the body, further comprising a delivery management circuit arranged to store delivery positions of the objects based on the determination of the proces
Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis · CPC title
in body cavities or body tracts, e.g. by using catheters · CPC title
characterised by features of the ultrasound transducer · CPC title
Arrangements or means for the introduction of sources into the body · CPC title
Acoustic tracking systems, e.g. using ultrasound · CPC title
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