Filtration system for preparation of fluids for medical applications

Patent metadata

Field	Value
Publication number	US-10420871-B2
Application number	US-201715615655-A
Country	US
Kind code	B2
Filing date	Jun 6, 2017
Priority date	Jan 7, 2003
Publication date	Sep 24, 2019
Grant date	Sep 24, 2019

Abstract

A fluid preparation system has a sealed sterilized fluid circuit with a sealed sterilized container with a conductivity sensor in communication with an interior of said container. Further, at least one sealed connector is adapted for adding fluid to said container, and at least one sealed connector is adapted for removing fluid from said container. The conductivity sensor is contained in a test line in communication with said interior and is adapted to be connected to a source of suction thereby to draw a sample of contents of said container. Furthermore, the test line may have a check valve to prevent ingress of contaminants into said container, and the sealed connector is adapted for adding fluid to said container and may have an inline sterile filter. Furthermore, the system may have a controller that controls pumping actuators.

First claim

The invention claimed is:

1. A fluid preparation system, comprising:
a disposable component with preconnected tubing, the disposable component including a sealed sterilized fluid circuit that includes
a sealed sterilized container;
a conductivity sensor preconnected to the container and in communication with an interior of said container;
at least one sealed connector adapted for adding fluid to said container;
at least one sealed connector adapted for removing fluid from said container, wherein
said conductivity sensor is contained in a test line that is preconnected to the container, the test line being in communication with said interior and adapted to be connected to a source of suction thereby to draw a sample of contents of said container, and

wherein the conductivity sensor includes a cage that prevents a wall of the container from coming into contact with conductivity sensor.

2. A system as in claim 1 , wherein said test line includes a check valve to prevent ingress of contaminants into said container.

3. A system as in claim 2 , wherein said at least one sealed connector is adapted for adding fluid to said container and includes an inline sterile filter.

4. A system as in claim 1 , wherein said at least one sealed connector is adapted for adding fluid to said container and includes an inline sterile filter.

5. A system as in claim 3 , further comprising:
a controller;
pumping actuators;
clamps controlled by the controller; and
a deionization water purifier with a product water outlet having a connector for connection to said sterile filter.

6. A system as in claim 4 , further comprising:
a controller;
pumping actuators;
clamps controlled by the controller; and
a deionization water purifier with a product water outlet having a connector for connection to said sterile filter.

7. A system as in claim 1 , further comprising:
a controller;
pumping actuators;
clamps controlled by the controller; and
a deionization water purifier with a product water outlet having a connector for connection to a sterile filter.

8. The system of claim 7 , wherein the fluid circuit includes a quantity of medicament concentrate.

9. The system of claim 8 , wherein said controller is programmed to pump said concentrate into said sterilized container and to dilute the same using water from the product water outlet.

10. The system of claim 9 , wherein the controller reads a fluid quality sensor reading from said conductivity sensor and controls a pump to continue or discontinue pumping responsively to said sensor reading.

11. The system of claim 10 , wherein said controller is programmed to maintain a clamp on a mixed fluid outlet of said sterilized container responsively to said sensor reading.

12. The system of claim 5 , wherein the fluid circuit includes a quantity of medicament concentrate.

13. The system of claim 12 , wherein said controller is programmed to pump said concentrate into said sterilized container and to dilute the same using water from the product water outlet.

14. The system of claim 13 , wherein the controller reads a fluid quality sensor reading from said conductivity sensor and controls a pump to continue or discontinue pumping responsively to said sensor reading.

15. The system of claim 14 , wherein said controller is programmed to maintain a clamp on a mixed fluid outlet of said sterilized container responsively to said sensor reading.

16. A fluid preparation system, comprising:
a sealed sterilized fluid circuit with a sealed sterilized container with a conductivity sensor in communication with an interior of said container;
at least one sealed connector adapted for adding fluid to said container;
at least one sealed connector adapted for removing fluid from said container, wherein
the container is connected, through an opening, to a test line in communication with said interior that is adapted to be connected to a source of suction thereby to draw a sample of contents of said container past the conductivity sensor;
said opening includes a cage that prevents a flexible wall of the container from coming into contact with the opening and blocking flow through said opening.

17. The system according to claim 16 , wherein
the cage of the conductivity sensor is sealed to one wall of the container.

Assignees

• Nxstage Medical Inc

Inventors

• Burbank Jeffrey H
• Treu Dennis M
• Friederichs Goetz
• Green Brian C
• Mcdowell Christopher S
• Brugger James M

Classifications

• A61M1/1656 Primary

  Apparatus for preparing dialysates · CPC title

• A61M2205/12

  with interchangeable cassettes forming partially or totally the fluid circuit · CPC title

• A61M1/3462

  Circuits for the preparation thereof · CPC title

• A61M1/167

  Flexible packaging for solid concentrates · CPC title

• A61M1/1672

  using membrane filters, e.g. for sterilising the dialysate · CPC title