Vaccine pharmaceutical composition for transdermal administration

Patent metadata

Field	Value
Publication number	US-10420837-B2
Application number	US-201515514868-A
Country	US
Kind code	B2
Filing date	Oct 1, 2015
Priority date	Oct 2, 2014
Publication date	Sep 24, 2019
Grant date	Sep 24, 2019

Abstract

The present invention provides a vaccine pharmaceutical composition for transdermal administration which is safe, usable as a prophylactic or therapeutic agent for cancer or infectious diseases, and capable of safely and effectively inducing a systemic immune response. It can be administered to a human or animal skin, the vaccine pharmaceutical composition including: a lipopolysaccharide or its salt, derived from at least one gram-negative bacterium such as Serratia, Lelercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas , and Enterobacter , as an immunostimulant; and at least one antigen, the vaccine pharmaceutical composition having a mass ratio between the immunostimulant and the antigen, the total mass of the immunostimulant/the total mass of the antigen, of 0.002 to 500.

First claim

The invention claimed is:

1. A vaccine pharmaceutical composition for transdermal administration [to be administered to] a human or an animal,
the vaccine pharmaceutical composition comprising: a lipopolysaccharide or its salt derived from at least one gram-negative bacterium selected from the group consisting of Pantoea, Acetobacter, Zymomonas , and Xanthomonas , as an immunostimulant; and at least one antigen,
the vaccine pharmaceutical composition having a ratio of the total mass of the immunostimulant to the total mass of the antigen from 0.002:1 to 500:1.

2. The vaccine pharmaceutical composition for transdermal administration according to claim 1 , structured and arranged as a dosage form of a patch.

3. The vaccine pharmaceutical composition for transdermal administration according to claim 2 , wherein the patch includes a support and an adhesive layer containing an adhesive, and the adhesive contains a hydrophilic base material.

4. The vaccine pharmaceutical composition for transdermal administration according to claim 1 , which is used for inducing humoral immunity.

5. The vaccine pharmaceutical composition for transdermal administration according to claim 1 , which is used for treating an infectious disease.

6. The vaccine pharmaceutical composition for transdermal administration according to claim 1 , which is used for treating cancer.

7. The vaccine pharmaceutical composition for transdermal administration according to claim 1 , wherein the antigen is at least one of a pathogen-derived antigen and a cancer antigen.

8. A method for inducing humoral immunity comprising administering to the skin of a subject a vaccine pharmaceutical composition,
the vaccine pharmaceutical composition comprising: an immunostimulant-effective amount of a lipopolysaccharide or its salt derived from at least one gram-negative bacterium selected from the group consisting of Pantoea, Acetobacter, Zymomonas , and Xanthomonas , and at least one antigen,
the vaccine pharmaceutical composition having a ratio of the total mass of the immunostimulant to the total mass of the antigen from 0.002:1 to 500:1.

9. The method according to claim 8 , comprising administering the vaccine pharmaceutical composition by a patch.

10. The method of claim 9 , wherein the patch includes a support and an adhesive layer, the adhesive layer containing an adhesive, and the adhesive containing a hydrophilic base material.

11. The method according to claim 8 , wherein the subject is a human at risk of infection with an infectious disease.

12. The method according to claim 8 , wherein the subject is a human with cancer.

13. The method according to claim 8 , wherein the antigen is at least one of a pathogen-derived antigen and a cancer antigen.

14. The method according to claim 8 , wherein the administering induces humoral immunity in the subject.

15. The method according to claim 8 , wherein the subject is a human at risk for developing cancer.

16. The method according to claim 8 , wherein the administering reduces the likelihood of developing an infection disease.

17. The method according to claim 8 , wherein the administering reduces the likelihood of developing cancer.

Assignees

• Nitto Denko Corp

Inventors

• Shishido takuya
• Asari Daisuke
• Matsushita Kyohei
• Okubo Katsuyuki
• Hori Mitsuhiko

Classifications

• A61K39/12

  Viral antigens · CPC title

• A61K2039/70

  Multivalent vaccine · CPC title

• A61K2039/55572

  Lipopolysaccharides; Lipid A; Monophosphoryl lipid A · CPC title

• A61K39/39 Primary

  characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title

• A61K2039/54

  characterised by the route of administration · CPC title