Brachytherapy device for facilitating asymmetrical irradiation of a body cavity

Patent metadata

Field	Value
Publication number	US-10413750-B2
Application number	US-201615236265-A
Country	US
Kind code	B2
Filing date	Aug 12, 2016
Priority date	Nov 18, 2005
Publication date	Sep 17, 2019
Grant date	Sep 17, 2019

Abstract

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

First claim

What is claimed is:

1. A method of treating tissue adjacent a body cavity comprising:
inserting at least partially into the body cavity a device comprising a shaft and an inflatable member disposed about a portion of the shaft;
inflating the inflatable member such that at least a portion of the inflatable member at least partially contacts tissue that defines the body cavity;
expanding away from an axis of the shaft, spaced apart from but within the inflatable member, a radiation delivery tube; and
inserting a radiation source into the radiation delivery tube.

2. The method of claim 1 , wherein expanding the radiation delivery tube comprises not contacting an inner surface of the inflated inflatable member.

3. The method of claim 1 , wherein the radiation tube is disposed in the shaft and wherein the shaft is deflectable away from the axis.

4. The method of claim 3 , further comprising pulling a pull wire so as to expand the radiation delivery tube.

5. The method of claim 1 , further comprising pushing the radiation delivery tube into a lumen so as to expand the radiation delivery tube.

6. The method of claim 1 , wherein the radiation delivery tube is at least partially disposed in a compartmented support element that extends between a proximal end and a distal end of the inflatable member along the axis of the shaft, and wherein expanding the radiation delivery tube comprises extending the radiation delivery tube away from the compartmented support element.

7. The method of claim 6 , wherein the compartmented support element defines a compartment that is configured to receive at least a portion of the radiation delivery tube and extends longitudinally along the compartmented support element, and wherein extending the radiation delivery tube comprises radially extending the radiation delivery tube out of the compartment.

8. A brachytherapy method comprising:
inserting at least a portion of a brachytherapy device having an inflatable member into a body cavity;
inflating the inflatable member within the body cavity; and
radially expanding from a first position to a second position, a radiation delivery tube within the inflatable member, wherein radial expansion of the radiation delivery tube occurs separate from inflation of the inflatable member.

9. The method of claim 8 , wherein when in the first position, the radiation delivery tube is disposed in a support element within an interior of the inflatable member, and when in the second position, the radiation delivery tube extends from the support element, and wherein radially expanding the radiation delivery tube comprises extending the radiation delivery tube at least partially out of the support element.

10. The method of claim 9 , wherein extending the radiation delivery tube at least partially out of the support element comprises positioning the radiation delivery tube in a substantially curved configuration relative to the support element.

11. The method of claim 8 , further comprising restricting contact between the radiation delivery tube and an inner surface of the inflatable member when in the second position.

12. The method of claim 8 , wherein radially expanding the radiation delivery tube comprising sliding the radiation delivery tube within the brachytherapy device.

13. The method of claim 8 , wherein inflating the inflatable member comprises delivering inflation fluid into the brachytherapy device.

14. The method of claim 8 , further comprising inserting a radiation source into the radiation delivery tube.

15. A brachytherapy method comprising:
inserting a brachytherapy device into a body cavity, wherein the brachytherapy device comprises an inflatable element, at least one radiation delivery tube, and a support element wherein the support element is disposed at least partially within the inflatable element and defines a plurality of compartments, and wherein each compartment of the plurality of compartments is configured to receive a radiation delivery tube of the at least one radiation delivery tube;
inflating the inflatable element so as to contact the body cavity; and
extending the at least one radiation delivery tube out of the corresponding compartment.

16. The method of claim 15 , wherein the plurality of compartments extend longitudinally along the support element, and wherein extending the at least one radiation delivery tube comprises radially extending the at least one radiation delivery tube out of the corresponding compartment and within the inflatable element.

17. The method of claim 15 , wherein extending the at least one radiation delivery tube comprises expanding the at least one radiation delivery tube in a substantially curved configuration from the support element.

18. The method of claim 17 , wherein the at least one radiation delivery tube comprises a plurality of radiation delivery tubes, each received in corresponding compartments of the support element, and wherein extending the at least one radiation delivery tube comprises extending two or more radiation delivery tubes of the plurality of radiation delivery tubes out of the corresponding compartments.

19. The method of claim 18 , further comprising individually extending the two or more radiation delivery tubes out of the corresponding compartments.

20. The method of claim 15 , wherein the at least one radiation delivery tube comprises a plurality of radiation delivery tubes, each received in corresponding compartment of the support element, and wherein extending the at least one radiation delivery tube comprises extending one or more radiation delivery tubes of the plurality of radiation delivery tubes out of the corresponding compartment and fixing one or more radiation delivery tubes of the plurality of radiation delivery tubes at least partially within the corresponding compartment.

Assignees

• Hologic Inc

Inventors

• Lubock Paul
• Jones Michael L
• Louw Frank R

Classifications

• A61N5/1014 Primary

  Intracavitary radiation therapy · CPC title

• A61N5/1015 Primary

  Treatment of resected cavities created by surgery, e.g. lumpectomy · CPC title

• A61N2005/1004

  having expandable radiation sources · CPC title

• A61N5/1002

  Intraluminal radiation therapy · CPC title

• A61N2005/1005

  with asymmetrical radiation pattern · CPC title