Systems and methods for use and control of an automated separator with adsorption columns

Patent metadata

Field	Value
Publication number	US-10413652-B2
Application number	US-201114110587-A
Country	US
Kind code	B2
Filing date	Apr 13, 2011
Priority date	Apr 13, 2011
Publication date	Sep 17, 2019
Grant date	Sep 17, 2019

Abstract

Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

First claim

The invention claimed is:

1. A blood treatment system comprising, in combination:
a blood separation system configured to separate a blood component from blood; and
a disposable flow circuit including
a blood separation chamber in which the blood component is separated from the blood,
an adsorption device that is separate from the blood separation system and configured to receive at least a portion of said blood component from the blood separation system,
at least one cassette fluidly connected between the blood separation chamber and the adsorption device and including a plurality of valve stations configured to be actuated by the blood separation system to direct fluid flow through the at least one cassette, and
a plurality of containers fluidly connected to the at least one cassette, wherein the blood separation system includes
a fluid flow element configured to actuate the at least one cassette for flowing said at least a portion of said blood component from the blood separation system continuously into the adsorption device,
a plurality of valve actuators each configured to alternately open and close an associated one of the plurality of valve stations to change fluid flow through the at least one cassette, and
a controller configured to
control the fluid flow element based at least in part on one or more processing parameters including a maximum flow rate of said at least a portion of said blood component flowed into the adsorption device and/or a maximum pressure of said at least a portion of said blood component flowed into the adsorption device, and
actuate at least one of the plurality of valve actuators to change fluid flow through the at least one cassette so as to selectively allow and prevent fluid communication between the at least one cassette and at least one of the plurality of containers during flow of said blood component out of the blood separation system, with at least a portion of the blood component flowing out of the blood separation chamber being directed from the at least one cassette into said at least one of the plurality of containers instead of flowing from the at least one cassette into the adsorption device when there is fluid communication between the at least one cassette and said at least one of the plurality of containers, wherein
allowing fluid communication between the at least one cassette and said at least one of the plurality of containers during flow of said blood component out of the blood separation system causes the blood component to be flowed out of the blood separation chamber at a flow rate that is different from an actual flow rate at which said at least a portion of said blood component is flowed into the adsorption device and/or at a pressure that is different from an actual pressure at which said at least a portion of said blood component is flowed into the adsorption device, and
said actual flow rate is greater than zero.

2. The blood treatment system of claim 1 , wherein the controller is configured to receive as input the maximum flow rate and/or the maximum pressure at which said at least a portion of said blood component is to be flowed into the adsorption device.

3. The blood treatment system of claim 1 , wherein the controller is pre-programmed with the maximum flow rate and/or the maximum pressure at which said at least a portion of said blood component is to be flowed into the adsorption device.

4. The blood treatment system of claim 1 , wherein the blood separation system further includes at least one pressure sensing transducer configured to cooperate with the controller to determine the actual pressure and/or actual flow rate at which said at least a portion of said blood component is being flowed into the adsorption device.

5. The blood treatment system of claim 1 , wherein the blood separation system further includes at least one weight scale configured to cooperate with the controller to determine the actual flow rate at which said at least a portion of said blood component is being flowed into the adsorption device.

6. The blood treatment system of claim 1 , wherein
the blood separation system includes a centrifuge in which the blood component is separated from the blood, and
the controller is configured to allow the blood component to be flowed out of the centrifuge at a greater flow rate than the actual flow rate at which said at least a portion of said blood component is flowed into the adsorption device.

7. The blood treatment system of claim 1 , wherein the controller is configured to execute a reinfusion procedure following the blood separation system separating the blood component from blood and the adsorption device receiving said at least a portion of said blood component, the reinfusion procedure comprising flowing fluid to a blood source along a path that bypasses the adsorption device.

8. The blood treatment system of claim 1 , wherein the controller is configured to determine whether said blood component separated from the blood includes a cellular blood component and, if so, to prevent said blood component from flowing into the adsorption device.

9. The blood treatment system of claim 1 , wherein
the flow circuit includes a tubing including an upstream portion and a downstream portion,
the upstream portion of the tubing includes an upstream connector connected to an upstream portion of the adsorption device,
the downstream portion of the tubing includes a downstream connector connected to a downstream portion of the adsorption device, and
the upstream and downstream connectors are configured to be disconnected from the adsorption device and directly connected to each other.

10. The blood treatment system of claim 9 , wherein one of the upstream and downstream connectors comprises a male part of a luer connector and the other one of the upstream and downstream connectors comprises a female part of the luer connector that mates with the male part of the luer connector.

11. The blood treatment system of claim 1 , wherein
the fluid flow element comprises a peristaltic pump, and
the at least one cassette includes at least one tubing loop configured to cooperate with the peristaltic pump.

12. A blood treatment system comprising, in combination:
a blood separation system configured to separate a blood component from blood; and
a disposable flow circuit including
a blood separation chamber in which the blood component is separated from the blood,
an adsorption device that is separate from the blood separation system and configured to receive at least a portion of said blood component from the blood separation system,
at least one cassette fluidly connected between the blood separation chamber and the adsorption device and including a plurality of valve stations configured to be actuated by the blood separation system to direct fluid flow through the at least one cassette, and
a plurality of containers fluidly connected to the at least one cassette, including a vent container, wherein the blood separation system includes
a fluid flow element configured to actuate the at least one cassette for flowing said at least a portion of said blood component from the blood separation system continuously into the adsorption device,
a plurality of valve actuators each configured to alternately open and close an associated one of the plurality of valve stations to change fluid flow through the at least one cassette, and
a controller configured to
control the fluid flow element based at least in part on one or more processing parameters including a maximum flow rate of said at least a portion of said blood component flowed into the adsorption device and/or a maximum pressure of said at

Assignees

• Foley John T
• Prendergast Jonathan
• Nguyen Lan T
• Case Brian C
• Fenwal Inc

Inventors

• Foley John T
• Prendergast Jonathan
• Nguyen Lan T
• Case Brian C

Classifications

• A61M1/3641

  Pressure isolators · CPC title

• A61M1/3696

  with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation · CPC title

• A61M1/3693

  using separation based on different densities of components, e.g. centrifuging · CPC title

• A61M1/3639

  Blood pressure control, pressure transducers specially adapted therefor · CPC title

• A61M1/3679 Primary

  by absorption (A61M1/3675 takes precedence) · CPC title