Coherent optical imaging for detecting neural signatures and medical imaging applications using holographic imaging techniques

Patent metadata

Field	Value
Publication number	US-10413186-B2
Application number	US-201615348397-A
Country	US
Kind code	B2
Filing date	Nov 10, 2016
Priority date	Nov 12, 2015
Publication date	Sep 17, 2019
Grant date	Sep 17, 2019

Abstract

A neural imaging system may include an imaging array, an image data processor operably coupled to the imaging array to process image data received from the imaging array, and a beam angle separator disposed between the imaging array and an object being imaged. The beam angle separator may be configured to separate an object beam reflected from the object being imaged into a plurality of reference beams each having different angular separation with respect to the object beam. The image data processor may be configured to generate image data of the object for each one of the reference beams to correspond to a respective different depth within the object.

First claim

That which is claimed:

1. A neural imaging system comprising:
an imaging array;
an image data processor operably coupled to the imaging array to process image data received from the imaging array; and
a beam angle separator disposed between the imaging array and an object being imaged,
wherein the beam angle separator is configured to separate an object beam reflected from the object being imaged into a plurality of reference beams each having different angular separation with respect to the object beam,
wherein the image data processor is configured to generate image data of the object for each of the reference beams, the image data for each of the reference beams corresponding to a different depth within the object, and
wherein the beam angle separator comprises a plurality of windows, each of the windows refracting the object beam into a respective different one of the reference beams.

2. The neural imaging system of claim 1 , wherein a number of the plurality of windows corresponds to a number of different depths within the object at which image data is generated.

3. The neural imaging system of claim 1 , wherein each of the windows has a substantially same index of refraction.

4. The neural imaging system of claim 1 , wherein each of the windows is tilted at a different angle relative to a plane of the imaging array.

5. The neural imaging system of claim 1 , wherein the imaging array comprises a plurality of sub-arrays.

6. The neural imaging system of claim 5 , wherein the imaging array comprises at least four sub-arrays configured to sequentially acquire at least four images of the object.

7. The neural imaging system of claim 1 , further comprising an optical source, wherein the object beam is generated responsive to the optical source illuminating the object.

8. The neural imaging system of claim 7 , wherein the optical source comprises a moderate or short coherence length laser.

9. The neural imaging system of claim 1 , wherein the object comprises neural tissue and the different depths comprise different depths within the neural tissue.

10. A method comprising:
receiving an object beam reflected from an object;
separating the object beam into a plurality of reference beams each having different angular separation with respect to the object beam, wherein separating the object beam comprises refracting the object beam into the plurality of reference beams using a corresponding plurality of windows, each of the windows defining a respective different one of the reference beams;
generating image data of the object for each of the reference beams corresponding to a different depth within the object; and
transmitting the image data to an image data processor.

11. The method of claim 10 , wherein generating the image data comprises generating image data corresponding to a different depth within the object for each respective one of the windows.

12. The method of claim 10 , further comprising receiving, by an imaging array, light resulting from constructive interference of the reference beams with a plurality of object beams, separate from the object beam, that are reflected from the object.

13. The method of claim 10 , wherein image data for each reference beam is generated based at least on an incident angle of the respective reference beam on an imaging array.

14. A brain computer interface sensor, comprising:
an imaging array configured to be operably coupled to an image data processor to process image data received from the imaging array; and
a beam angle separator disposed between the imaging array and neural tissue being imaged,
wherein the beam angle separator is configured to separate an object beam reflected from the neural tissue being imaged into a plurality of reference beams each having different angular separation with respect to the object beam,
wherein the beam angle separator comprises a plurality of windows, each of the windows refracting the object beam into a respective different one of the reference beams.

15. The brain computer interface sensor of claim 14 , wherein each of the reference beams corresponds to an image at a different depth within the neural tissue.

16. The brain computer interface sensor of claim 14 , wherein each of the windows has a substantially same index of refraction.

17. The brain computer interface sensor of claim 14 , wherein each of the windows is tilted at a different angle relative to a plane of the imaging array.

18. The neural imaging system of claim 1 , wherein each reference beam is received by the imaging array at a respective incident angle relative to a plane of the imaging array due to each reference beam having different angular separation, and
wherein the image data processor is configured to generate the image data of the object for each of the reference beams based on the respective incident angles.

19. The method of claim 10 , further comprising receiving, at an imaging array, each reference beam at a respective incident angle relative to a plane of the imaging array due to each reference beam having different angular separation.

20. The brain computer interface sensor of claim 14 , wherein each reference beam is formed to be received by the imaging array at a respective incident angle relative to a plane of the imaging array due to each reference beam having different angular separation, and wherein the reference beams are distinguishable based on the respective incident angle for each of the reference beams.

Assignees

• Univ Johns Hopkins

Inventors

• Blodgett David W
• Chevillet Mark A
• Mcloughlin Michael P

Classifications

• G16H30/40

  for processing medical images, e.g. editing · CPC title

• G03H2226/13

  Multiple recording means · CPC title

• G03H2222/20

  Coherence of the light source · CPC title

• G03H2001/0469

  Object light being reflected by the object · CPC title

• G03H1/0465

  Particular recording light; Beam shape or geometry (G03H1/06 takes precedence) · CPC title