Probe adaptor assembly

Patent metadata

Field	Value
Publication number	US-10410848-B2
Application number	US-201815947609-A
Country	US
Kind code	B2
Filing date	Apr 6, 2018
Priority date	Apr 11, 2016
Publication date	Sep 10, 2019
Grant date	Sep 10, 2019

Abstract

An apparatus for connecting an ionization probe assembly to a mass and/or ion mobility spectrometer is disclosed. The apparatus comprises: an attachment member for releasably attaching a probe assembly to the apparatus; a cap for enclosing the attachment member; wherein the apparatus is operable to deliver a voltage to a probe assembly only when the cap is arranged to enclose the attachment member; and wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus.

First claim

The invention claimed is:

1. Apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the apparatus comprising:
an attachment member for releasably attaching a probe assembly to the apparatus; and
a cap for enclosing the attachment member, the cap comprising an aperture through which at least a portion of the probe assembly can pass;
wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus; and
wherein the apparatus comprises a device configured to close the aperture when the cap is arranged to enclose the attachment member and when no probe assembly is attached to the apparatus.

2. The apparatus of claim 1 , wherein the cap is configurable to enclose the attachment member when no probe assembly is attached to the apparatus so as to prevent a probe assembly being brought into contact with the attachment member.

3. The apparatus of claim 1 , wherein the device is configured such that the aperture is openable, in use, only when the attachment member is not enclosed by the cap.

4. The apparatus of claim 1 , wherein the device comprises one or more balls or other objects and one or more pockets for receiving the one or more balls or other objects.

5. The apparatus of claim 4 , wherein the one or more balls or other objects have a size and/or shape such that the one or more balls or other objects cannot pass through the aperture.

6. The apparatus of claim 4 , wherein the one or more balls or other objects have a diameter greater than the diameter of the aperture.

7. The apparatus of claim 4 , wherein the one or more pockets comprise at least a first pocket for receiving the one or more balls or other objects, and wherein the cap is configured such that, when the cap is in an upright position, the one or more balls or other objects will fall into the first pocket.

8. The apparatus of claim 7 , wherein the one or more pockets further comprise one or more second pockets, and wherein the cap is configured such that, when the cap is in a horizontal position, the one or more balls or other objects will fall into the one or more second pockets.

9. The apparatus of claim 8 , wherein the one or more second pockets comprise a single pocket that extends in a loop around the aperture.

10. An adaptor for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the adaptor comprising apparatus as claimed in claim 1 .

11. A mass and/or ion mobility spectrometer comprising apparatus as claimed in claim 1 .

12. A method of delivering eluent to a mass and/or ion mobility spectrometer comprising:
providing a probe assembly;
providing apparatus as claimed in claim 1 ;
releasably attaching the probe assembly to the apparatus using the attachment member; and
supplying eluent to the probe assembly such that eluent is transmitted through the probe assembly into the spectrometer.

13. Apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the apparatus comprising:
an attachment member for releasably attaching a probe assembly to the apparatus; and
a probe tip configured to receive a capillary of the probe assembly;
wherein the apparatus is configured such that the position of the capillary relative to the probe tip remains substantially unaltered when a probe assembly is detached from and/or attached to the apparatus.

14. The apparatus of claim 13 , wherein:
the probe tip comprises a capillary configured to receive the capillary of the probe assembly; and
the apparatus is configured such that the position of the capillary relative to the probe tip capillary remains substantially unaltered when a probe assembly is detached from and/or attached to the apparatus.

15. The apparatus of claim 14 , wherein:
the apparatus further comprises a cap for enclosing the attachment member;
the attachment member is provided in a main body of the apparatus; and
the cap is releasably securable to the main body so as to enclose the attachment member.

16. The apparatus of claim 15 , wherein:
the cap comprises a first mechanism that is engageable with a second mechanism in the main body; and
the first and/or second mechanisms are configured such that the position of the capillary relative to the probe tip remains substantially unaltered when the cap is secured to and/or released from the main body.

17. The apparatus of claim 16 , wherein:
the cap further comprises one or more springs or other elastic devices that are connected to the first and/or second mechanisms;
wherein the one or more springs or other elastic devices are configured so as to be elastically deformed when the first and/or second mechanisms are moved.

18. Apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the apparatus comprising:
an attachment member for releasably attaching a probe assembly to the apparatus; and
a cap for enclosing the attachment member, the cap comprising two or more buttons or flippers;
wherein the two or more buttons or flippers are configured such that when the buttons or flippers are pushed together, the cap is opened.

19. The apparatus of claim 18 , wherein the two or more buttons or flippers are configured such that a pinching action is required in order to open the cap.

20. The apparatus of claim 18 , wherein the cap further comprises one or more springs or elastic devices, wherein the one or more springs or elastic devices are configured such that when the cap is opened, the cap is ejected from the apparatus.

Assignees

• Micromass Ltd

Inventors

• Trivett Ian
• O'Brien Stephen
• Dutton Graeme

Classifications

• G01N30/7266

  by electric field, e.g. electrospray · CPC title

• H01J49/167

  Capillaries and nozzles specially adapted therefor; (electrostatic spraying per se B05B5/00) · CPC title

• H01J49/0422 Primary

  for gaseous samples (interfaces to gas chromatographs G01N30/7206) · CPC title

• G01N30/7206

  interfaced to gas chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04) · CPC title

• H01J49/0404 Primary

  Capillaries used for transferring samples or ions (electrospray nozzles H01J49/167) · CPC title