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Ligands modified by circular permutation as agonists and antagonists
US10407481B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10407481-B2 |
| Application number | US-201615218193-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 25, 2016 |
| Priority date | Jun 8, 2012 |
| Publication date | Sep 10, 2019 |
| Grant date | Sep 10, 2019 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.
First claim
Opening claim text (preview).
The invention claimed is: 1. A fusion polypeptide comprising the amino acids 1-303 of SEQ ID NO: 26 or an amino acid sequence homologous thereto having at least about 98% amino acid sequence identity over the length of amino acids 1-303 of SEQ ID NO: 26 and having the receptor agonist activity of amino acids 1-303 of SEQ ID NO: 26. 2. A pharmaceutical composition comprising the fusion polypeptide of claim 1 , and a pharmaceutically acceptable excipient.
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Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title
Immunosuppressants, e.g. drugs for graft rejection · CPC title
Immunomodulators · CPC title
Drugs for immunological or allergic disorders · CPC title
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- What does patent US10407481B2 cover?
- The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist act…
- Who is the assignee on this patent?
- Alkermes Inc, Alkermes Pharma Ireland Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07K14/5412. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).