System and method for cooling the brain of a human subject

Patent metadata

Field	Value
Publication number	US-10406022-B2
Application number	US-201916242527-A
Country	US
Kind code	B2
Filing date	Jan 8, 2019
Priority date	Jan 8, 2018
Publication date	Sep 10, 2019
Grant date	Sep 10, 2019

Abstract

A system for cooling the brain of a human subject, includes a cooling subsystem which inputs a flow of air or breathable gas, cool the air or breathable gas, and output cooled air or breathable gas which is delivered to a human subject. A flow control device to controls a flow rate of the flow of the air or breathable gas input to the cooling subsystem and a flow rate of the cooled air or breathable gas delivered to the human subject. One or more flow rate sensors measure at least a flow rate of flow of cooled air or breathable gas. One or more temperature sensors measure at least a temperature of a brain and the temperature of the flow of cooled air or breathable gas. A controller adjusts a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject to cool the brain of the human subject.

First claim

What is claimed is:

1. A system for cooling the brain of a human subject, the system comprising:
a cooling subsystem configured to input a flow of air or breathable gas, cool the air or breathable gas, and output cooled air or breathable gas to a line coupled to a device adapted to deliver the cooled air or breathable gas to a human subject, the cooling subsystem including a flat gas block comprised of a thermally conductive material and a flat thermal electric cooling (TEC) device coupled between the flat gas block and a flat conductor block;
a flow control device coupled to the cooling subsystem configured to control a flow rate of the flow of the air or breathable gas input to the cooling subsystem and a flow rate of the cooled air or breathable gas output to the line;
one or more flow rate sensors coupled to the cooling subsystem configured to measure at least a flow rate of flow of cooled air or breathable gas;
one or more temperature sensors configured to measure at least a temperature of a brain or a brain correlative site of the human subject and the temperature of the flow of cooled air or breathable gas; and
a controller coupled to the cooling subsystem, the flow control device, the one or more flow rate sensors, and the one or more temperature sensors, the controller configured to adjust a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject based on at least the measured temperature of the brain or the brain correlative site and the measured flow rate of the flow of cooled air or breathable gas to cool the brain of the human subject.

2. The system of claim 1 in which the controller is configured to adjust the temperature and the flow rate of the flow of cooled air or breathable gas to provide therapeutic hypothermic (TH) and/or target temperature management (TTM) to normothermic levels.

3. The system of claim 1 in which the controller is configured to control the flow control device to provide a flow rate of the cooled air or breathable gas at flow rate in the range of about 0 L/min to about 50 L/min.

4. The system of claim 1 in which the cooling subsystem cooling subsystem is configured to input the air or breathable gas having a temperature in the range of about −10° C. to about 10° C.

5. The system of claim 4 in which the controller is configured to control the cooling subsystem to cool the air or breathable gas and provide the flow of cooled air or breathable gas delivered to the human subject having a temperature in the range of about −14° C. to about 7° C.

6. The system of claim 1 in which the one or more temperature sensors includes a tympanic sensor or temporal artery sensor.

7. The system of claim 1 in which the device adapted to deliver the cooled air or breathable gas to a human subject includes a nasal cannula.

8. The system of claim 7 in which the one or more temperature sensors are adapted to be placed on an end of the nasal cannula.

9. The system of claim 1 in which the controller is configured to control the flow control device to adjust a pressure of the flow of cooled air or breathable gas.

10. The system of claim 1 in which the cooling subsystem includes a gas block comprised of a thermally conductive material, the gas block including an inlet configured to input the flow of air or breathable gas and an outlet configured to output the flow of cooled air or breathable gas.

11. The system of claim 10 in which the air block includes a plurality of flow channels comprised of the thermally conductive material configured to cool the flow of air or breathable gas and provide and direct the flow of cooled air or breathable gas to the outlet.

12. The system of claim 1 in which the cooling subsystem includes a heat transfer subsystem coupled to the gas block and configured as a thermal electric cooling (TEC) device.

13. The system of claim 12 in which the controller is configured to control a current or voltage applied to the TEC to provide a cooling temperature on a side of the TEC in contact with the gas block to cool the source of the flow of air or breathable gas and provide the flow of cooled air or breathable gas or to provide a heating temperature on a side of the TEC in contact with the gas block to heat the source of the flow of air or breathable gas to increase the temperature of the flow of cooled air or breathable gas.

14. The system of claim 13 further including a heat exchange transfer subsystem coupled to the heat transfer subsystem configured to remove heat from the heat transfer subsystem.

15. The system of claim 14 in which heat exchange transfer subsystem includes a conductor block coupled to a side of the TEC and conductive pipes coupled to conductive fins.

16. The system of claim 15 further including a fan coupled to the conductive fins.

17. A method for cooling the brain of a human subject, the method comprising:
receiving a flow of the air or breathable gas;
cooling the air or breathable gas;
outputting a flow of cooled air or breathable gas to a line coupled to a device adapted to deliver the cooled air or breathable gas to a human subject, the device including a flat gas block comprised of a thermally conductive material and a flat thermal electric cooling (TEC) device coupled between the flat gas block and a flat conductor block
controlling a flow rate of the flow of the air or breathable gas and a flow rate of the cooled air or breathable gas output to the line;
measuring at least a flow rate of flow of cooled air or breathable gas;
measuring at least a temperature of a brain or brain correlative site of the human subject and a temperature of the flow of cooled air or breathable gas; and
adjusting a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject based on at least the measured temperature of the brain or the brain correlative site and the measured flow rate of the flow of cooled air or breathable gas to cool the brain of the human subject.

18. The method of claim 17 further including adjusting the temperature and the flow rate of the flow of cooled air or breathable gas to provide therapeutic hypothermic (TH) and target temperature management (TTM) to normothermic levels.

19. The method of claim 17 further including providing a flow rate of cooled air or breathable gas at a flow rate in the range of about 0 to about 50 L/m.

20. The method of claim 17 further including receiving the flow of the air or breathable gas having a temperature in the range of about −10° C. to about 10° C.

21. The method of claim 20 further including cooling the flow of the air or breathable gas to a temperature in the range of about −14° C. to about 7° C.

22. The method of claim 17 in which the device adapted to deliver the flow of the air or breathable gas to the human subject includes a nasal cannula.

23. The method of claim 17 further including adjusting a pressure of the flow of cooled air or breathable gas.

24. The method of claim 17 further including providing a gas block comprised of a thermally conductive material, the gas block including an inlet to receive the flow of air or breathable gas and an outlet configured to output the flow of cooled air or breathable gas.

25. The method of claim 24 further including providing a heat transfer subsystem coupled to the gas block configured as a thermal electric cooling (TEC) device.

Assignees

• Vivonics Inc

Inventors

• Myers Ryan
• Binette Ryan

Classifications

• A61B5/4836

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61B5/6817

  Ear canal · CPC title

• A61B5/01

  Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20) · CPC title

• A61M5/44 Primary

  having means for cooling or heating the devices or media · CPC title

• A61F2007/0095

  with a temperature indicator · CPC title