Pharmaceutical compositions of near IR closed chain, sulfo-cyanine dyes

Patent metadata

Field	Value
Publication number	US-10405753-B2
Application number	US-201514937641-A
Country	US
Kind code	B2
Filing date	Nov 10, 2015
Priority date	Nov 10, 2015
Publication date	Sep 10, 2019
Grant date	Sep 10, 2019

Abstract

Sterile and non-toxic pharmaceutical compositions of near IR, closed chain, sulfo-cyanine dyes and methods for visualizing tissue under illumination with near-infrared radiation are provided.

First claim

What is claimed is:

1. A method of visualizing tissue in a patient, the method comprising the step of administering a sterile pharmaceutical composition comprising a unit dosage form of a compound having the formula:

wherein,
R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, C 1-3 alkyl, or —CO 2 T;
X is a single bond, —O—, or —S—;
subscripts a, b, c, and d are each independently an integer from 1 to 6, and
T is a metal ion, H, or a negative charge;
wherein the composition is non-toxic, and wherein the unit dosage form delivers to the patient an amount sufficient to visualize tissue; and further comprising imaging the tissue under illumination with near-infrared radiation, and obtaining at least one image of the tissue from the patient using the composition.

2. The method of claim 1 wherein the unit dosage form delivers to the patient an amount between 0.05 and 8 mg/kg.

3. The method of claim 1 further comprising obtaining the image during administration, after administration, or both during and after administration of the composition.

4. The method of claim 1 where the step of administering a sterile pharmaceutical composition is by intravenous injection.

5. The method of claim 1 where the composition is injected into a circulatory system.

6. The method of claim 1 further comprising visualizing a patient area on which surgery is or will be performed, or for viewing a patient area otherwise being examined by a medical professional.

7. The method of claim 6 further comprising performing a surgical procedure on the patient area based on the visualization of the surgical area.

8. The method of claim 6 further comprising viewing a patient area on which an ophthalmic, arthroscopic, laparoscopic, cardiothoracic, muscular, or neuro procedure is or will be performed.

9. The method of claim 1 further comprising obtaining ex vivo images of at least a portion of the patient.

10. The method of claim 1 wherein the compound has the formula:

wherein,
R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, —CH 3 , or —CO 2 T.

11. The method of claim 1 wherein the compound is:

Assignees

• Intuitive Surgical Operations

Inventors

• Sorger Jonathan

Classifications

• A61K9/00

  Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12)} · CPC title

• C09B23/0025 Primary

  the substituent being bound through an oxygen atom · CPC title

• C09B23/0066

  the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid) · CPC title

• A61B5/0082 Primary

  adapted for particular medical purposes · CPC title

• C09B23/086

  more than five >CH- groups · CPC title