Compounds and methods for preventing or treating sensory hair cell death
US-9493482-B2 · Nov 15, 2016 · US
Compounds and methods for preventing or treating sensory hair cell death
US10399994B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10399994-B2 |
| Application number | US-201615547438-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 5, 2016 |
| Priority date | Feb 6, 2015 |
| Publication date | Sep 3, 2019 |
| Grant date | Sep 3, 2019 |
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- Title
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Abstract
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Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for preventing and/or protecting against sensory hair cell death associated with exposure to an ototoxic agent in an individual comprising administering to the individual a therapeutically effective amount of: or a pharmaceutically acceptable salt thereof. 2. The method of claim 1 , wherein the ototoxic agent is an aminoglycoside antibiotic, chemotherapeutic agent, loop diuretic, antimalarial sesquiterpene lactone endoperoxide, antimalarial quinine, salicylate, or interferon polypeptide. 3. The method of claim 2 , wherein the ototoxic agent is an aminoglycoside antibiotic. 4. The method of claim 3 , wherein the aminoglycoside antibiotic is selected from streptomycin, neomycin, framycetin, paromomycin, paromomycin sulfate, ribostamycin, kanamycin, amikacin, arbekacin, bekanamycin, dibekacin, tobramycin, spectinomycin, hygromycin B, gentamicin, netilmicin, sisomicin, isepamicin, verdamicin, and astromicin. 5. The method of claim 4 , wherein the aminoglycoside antibiotic is streptomycin. 6. The method of claim 4 , wherein the aminoglycoside antibiotic is neomycin. 7. The method of claim 4 , wherein the aminoglycoside antibiotic is amikacin. 8. The method of claim 2 , wherein the ototoxic agent is a chemotherapeutic agent. 9. The method of claim 8 , wherein the chemotherapeutic agent is cisplatin or carboplatin.
Assignees
Inventors
Classifications
Drugs for disorders of the senses · CPC title
- C07D495/18Primary
Bridged systems · CPC title
8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine · CPC title
having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins · CPC title
Platinum; Compounds thereof · CPC title
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- What does patent US10399994B2 cover?
- Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Met…
- Who is the assignee on this patent?
- Univ Washington, Hutchinson Fred Cancer Res, Oricula Therapeutics Llc
- What technology area does this patent fall under?
- Primary CPC classification C07D495/18. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).