Optical imaging device and method for imaging a sample

Patent metadata

Field	Value
Publication number	US-10398306-B2
Application number	US-201414765778-A
Country	US
Kind code	B2
Filing date	Mar 3, 2014
Priority date	Mar 7, 2013
Publication date	Sep 3, 2019
Grant date	Sep 3, 2019

Abstract

According to embodiments of the present invention, an optical imaging device is provided. The optical imaging device includes an optics arrangement configured to generate an extended-source illumination pattern including a plurality of separate spectral bands, and to illuminate a respective section of a sample to be imaged with a respective spectral band of the plurality of separate spectral bands, wherein the optics arrangement is further configured to form an interference signal from a sample light comprising respective return lights from respective sections of the sample illuminated by respective spectral bands of the extended-source illumination pattern, and a reference light, and a detector configured to receive the interference signal for generating an image corresponding to the sections of the sample. According to further embodiments of the present invention, a method for imaging a sample and a method for generating an image are also provided.

First claim

The invention claimed is:

1. An optical imaging device comprising:
an optics arrangement comprising:
a dispersive element configured to receive a first light and generate an extended-source illumination pattern comprising a plurality of separate spectral bands from the first light, the extended-source illumination pattern having a form which is elongated in a direction and the optics arrangement being configured to illuminate sections of a sample to be imaged with the plurality of separate spectral bands, and
a scanning device configured to scan the extended-source illumination pattern across the sections of the sample at least along said direction such that each section of the sections of the sample is illuminated by each of the plurality of separate spectral bands as a function of time at respective time instances, wherein the optics arrangement is further configured to form an interference signal from a sample light comprising respective return lights from the sections of the sample, and a reference light; and

a detector configured to receive the interference signal for generating an image corresponding to the sections of the sample, including, for each section of the sections of the sample, imaging said section based on information obtained from the interference signal corresponding to said each of the plurality of separate spectral bands that illuminated said section at said respective time instances.

2. The optical imaging device as claimed in claim 1 , wherein the dispersive element comprises at least one of a prism and a grating.

3. The optical imaging device as claimed in claim 1 , wherein the optics arrangement comprises a collimation lens configured to collimate the first light from which the extended-source illumination pattern is generated.

4. The optical imaging device as claimed in claim 1 , wherein the optics arrangement comprises a beam splitter arranged to receive and split a light into the first light from which the extended-source illumination pattern is generated, and a second light from which the reference light is derived.

5. The optical imaging device as claimed in claim 1 , wherein the optics arrangement comprises a relay optics assembly optically coupled to the extended-source illumination pattern.

6. The optical imaging device as claimed in claim 1 , wherein the optics arrangement comprises a beam splitter arranged to receive and split light corresponding to the extended-source illumination pattern into a first portion for illuminating the respective sections of the sample, and a second portion from which the reference light is derived.

7. The optical imaging device as claimed in claim 1 , wherein the optics arrangement comprises focusing optics for focusing the extended-source illumination pattern onto a focal plane on the sample corresponding to the sections of the sample.

8. The optical imaging device as claimed in claim 1 , wherein the detector comprises a grating arranged to spectrally disperse the interference signal.

9. The optical imaging device as claimed in claim 1 , further comprising a processor configured to obtain said information for each section of the sections of the sample from the interference signal for generating the image corresponding to the sections of the sample.

10. The optical imaging device as claimed in claim 9 , wherein the processor is configured:
to obtain, from the interference signal for each section of the sections of the sample, said information corresponding to said each of the plurality of separate spectral bands that illuminated said section at said respective time instances; and
to interpolate the obtained information in time domain to obtain information corresponding to said section for a subsequent spectral band adjacent to a respective spectral band of the plurality of separate spectral bands.

11. The optical imaging device as claimed in claim 9 , wherein the processor is configured to perform Fourier transform on the interference signal.

12. The optical imaging device as claimed in claim 1 , further comprising a light source, wherein the optics arrangement is configured to generate the extended-source illumination pattern based on a light produced by the light source.

13. The optical imaging device as claimed in claim 1 , wherein the extended-source illumination pattern is an oblong illumination pattern.

14. The optical imaging device as claimed in claim 1 , wherein the extended-source illumination pattern is a line illumination pattern.

15. The optical imaging device as claimed in claim 1 , wherein the extended-source illumination pattern has a length with a corresponding angular dimension that is more than 1.5 mrad.

16. A method for imaging a sample, the method comprising:
generating, by a dispersive element, an extended-source illumination pattern comprising a plurality of separate spectral bands, from a first light received by the dispersive element, the extended-source illumination pattern having a form which is elongated in a direction;
illuminating sections of a sample to be imaged with the plurality of separate spectral bands;
scanning the extended-source illumination pattern across the sections of the sample at least along said direction such that each section of the sections of the sample is illuminated by each of the plurality of separate spectral bands as a function of time at respective time instances;
forming an interference signal from a sample light comprising respective return lights from the sections of the sample, and a reference light; and
generating an image corresponding to the sections of the sample based on the interference signal, including, for each section of the sections of the sample, imaging said section based on information obtained from the interference signal corresponding to said each of the plurality of separate spectral bands that illuminated said section at said respective time instances.

17. The method as claimed in claim 16 , further comprising providing a collimated light, wherein generating an extended-source illumination pattern comprises generating the extended-source illumination pattern from the collimated light.

18. The method as claimed in claim 16 , further comprising:
receiving a light; and
splitting the light into the first light from which the extended-source illumination pattern is generated, and a second light from which the reference light is derived.

19. The method as claimed in claim 16 , further comprising focusing and collimating the plurality of separate spectral bands of the extended-source illumination pattern.

20. The method as claimed in claim 16 , further comprising splitting light corresponding to the extended-source illumination pattern into a first portion for illuminating the respective sections of the sample, and a second portion from which the reference light is derived.

21. The method as claimed in claim 16 , further comprising focusing the extended-source illumination pattern onto a focal plane on the sample corresponding to the sections of the sample.

22. The method as claimed in claim 16 , further comprising spectrally dispersing the interference signal.

23. The method as claimed in claim 16 , wherein generating an image comprises obtaining said information for each section of the sections of the sample from the interference signal.

24. The method as claimed in claim 23 , wherein obtaining information comprises:
obtaining, from the interference signal for each section of the sections of t

Assignees

• Univ Nanyang Tech

Inventors

• Liu Linbo

Classifications

• G01B2290/20

  Dispersive element for generating dispersion · CPC title

• G01B9/02044

  Imaging in the frequency domain, e.g. by using a spectrometer · CPC title

• G01B9/02034

  characterised by particularly shaped beams or wavefronts · CPC title

• G01B9/02007 Primary

  Two or more frequencies or sources used for interferometric measurement (using only beat G01B9/02003) · CPC title

• A61B5/0066

  Optical coherence imaging · CPC title