Detection and use of low molecular-weight modulators of the cold-menthol receptor TRPM8
US-9346823-B2 · May 24, 2016 · US
US10398159B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10398159-B2 |
| Application number | US-201715610958-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 1, 2017 |
| Priority date | Sep 20, 2011 |
| Publication date | Sep 3, 2019 |
| Grant date | Sep 3, 2019 |
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The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.
Opening claim text (preview).
The invention claimed is: 1. A method for the in-vitro or in-vivo modulation of the cold menthol receptor TRPM8, where the receptor is brought into contact with a substance selected from compounds P1 to P31: No. Formula P1 P2 P3 P4 P5 P6 P7 P8 P9 P10 P11 P12 P13 P14 P15 P16 P17 P18 P19 P20 P21 P22 P23 P24
Ortho-condensed systems · CPC title
Ketones, e.g. benzophenone · CPC title
Cyclic thioketals · CPC title
having condensed rings, e.g. indol · CPC title
linked by a carbon chain containing only aliphatic carbon atoms · CPC title
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