Biscationic and triscationic amphiphiles as antimicrobial agents
US-2016278375-A1 · Sep 29, 2016 · US
Polycationic amphiphiles as antimicrobial agents
US10398142B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10398142-B2 |
| Application number | US-201615147219-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 5, 2016 |
| Priority date | Nov 5, 2013 |
| Publication date | Sep 3, 2019 |
| Grant date | Sep 3, 2019 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 10 , or R 11 is H or a C 1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH 2 , —NHR′, —NR′ 2 , —N—C(O)R′, —N—C(O)CR′═CR′, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF 3 , —OCF 3 , halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R 7 , R 8 or R 9 is a C 1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH 2 , —NHR′, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF 3 , and —OCF 3 . R′ is H or a C 1-4 alkyl. X or Y is a halogen. m and n are integers in the range from 1 to 25.
First claim
Opening claim text (preview).
What is claimed is: 1. An antimicrobial composition comprising a compound having the formula wherein each of m and n is 10, 11 or 12, and each of R 1 , R 2 , R 3 , R 5 and R 6 is methyl or ethyl, R 4 is hydrogen, methyl or ethyl, and each of X and Y is independently selected from the group consisting of halogen, tosylate, citrate and combinations thereof. 2. The antimicrobial composition of claim 1 , wherein the compound has the formula 3. The antimicrobial composition of claim 1 , wherein the compound is compound (10, 3, 0′, 3, 10) having the formula: compound (10,3,1,3,10) having the formula:
Assignees
Inventors
Classifications
the carbon skeleton being acyclic and saturated · CPC title
having quaternised nitrogen atoms bound to acyclic carbon atoms · CPC title
- A01N33/12Primary
Quaternary ammonium compounds · CPC title
six-membered rings · CPC title
containing two or more pyridine rings directly linked together, e.g. bipyridyl · CPC title
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- What does patent US10398142B2 cover?
- The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 10 , or R 11 is H or a C 1-12 alkyl unsubstituted or optionally substituted with a functional group such as —O…
- Who is the assignee on this patent?
- Univ Temple, Univ Villanova
- What technology area does this patent fall under?
- Primary CPC classification A01N33/12. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).