N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)cinnamamides as potential anticancer agents and preparation thereof

Patent metadata

Field	Value
Publication number	US-10392385-B2
Application number	US-201716071687-A
Country	US
Kind code	B2
Filing date	Jan 20, 2017
Priority date	Jan 22, 2016
Publication date	Aug 27, 2019
Grant date	Aug 27, 2019

Abstract

A compound of general formula A, useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. General formula A R 1 =3-F, 3,4,5-OMe, 4-OMe, H, 4-CF 3 , 4-Cl, 4-OH-3-OMe, 3,4-CH 2 —O—CH 2 , 3,5-F, 4-OH, 1-napthyl, 9-phenanthryl, 4-Me. R 2 =3,4,5-OMe, 3,4-Cl, 4-F, 3,5-F, 2,5-OMe, 4-Cl, 4-OH-3-OMe, 3-OH, 3,4,5-OH, 4-CF 3 , 4-OMe, 4-NH 2 .

First claim

We claim:

1. N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl) cinnamamides of formula A:

wherein
R 1 =3-F, 3,4,5-OMe, 4-OMe, H, 4-CF 3 , 4-Cl, 4-OH-3-OMe, 3,4-CH 2 —O—CH 2 , 3,5-F, 4-OH, 1-napthyl, 9-phenanthryl, or 4-Me, and
R 2 =3,4,5-OMe, 3,4-Cl, 4-F, 3,5-F, 2,5-OMe, 4-Cl, 4-OH-3-OMe, 3-OH, 3,4,5-OH, 4-CF 3 , 4-OMe, or 4-NH 2 .

2. The compound of formula A as claimed in claim 1 , wherein the representative compounds of formula 1a-l to 13a-l comprises;
(E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl) acrylamide (1a)
(E)-3-(3,4-dichlorophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1b)
(E)-3-(4-fluorophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1c)
(E)-3-(3,5-difluorophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1d)
(E)-3-(2,5-dimethoxyphenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1e)
(E)-3-(4-chlorophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1f)
(E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (1g)
(E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3-hydroxyphenyl)acrylamide (1h)
(E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (1i)
(E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (1j)
(E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-methoxyphenyl)acrylamide (1k)
(E)-3-(4-aminophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1l)
(E)-3-(3,4,5-trimethoxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2a)
(E)-3-(3,4-dichlorophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2b)
(E)-3-(4-fluorophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2c)
(E)-3-(3,5-difluorophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2d)
(E)-3-(2,5-dimethoxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2e)
(E)-3-(4-chlorophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2f)
(E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2g)
(E)-3-(3-hydroxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2h)
(E)-3-(3,4,5-trihydroxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2i)
(E)-3-(4-(trifluoromethyl)phenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2j)
(E)-3-(4-methoxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2k)
(E)-3-(4-aminophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2l)
(E)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (3a)
(E)-3-(3,4-dichlorophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3b)
(E)-3-(4-fluorophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3c)
(E)-3-(3,5-difluorophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3d)
(E)-3-(2,5-dimethoxyphenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3e)
(E)-3-(4-chlorophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3f)
(E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3g)
(E)-3-(3-hydroxyphenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3h)
(E)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (3i)
(E)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (3j)
(E)-3-(4-methoxyphenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3k)
(E)-3-(4-aminophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3l)
(E)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (4a)
(E)-3-(3,4-dichlorophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4b)
(E)-3-(4-fluorophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4c)
(E)-3-(3,5-difluorophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4d)
(E)-3-(2,5-dimethoxyphenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4e)
(E)-3-(4-chlorophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4f)
(E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4g)
(E)-3-(3-hydroxyphenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4h)
(E)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (4i);
(E)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (4j)
(E)-3-(4-methoxyphenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4k)
(E)-3-(4-aminophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4l)
(E)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (5a)
(E)-3-(3,4-dichlorophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5b)
(E)-3-(4-fluorophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5c)
(E)-3-(3,5-difluorophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5d)
(E)-3-(2,5-dimethoxyphenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5e)
(E)-3-(4-chlorophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5f)
(E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5g)
(E)-3-(3-hydroxyphenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5h)
(E)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (5i)
(E)-3-(4-(trifluoromethyl)phenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5j)
(E)-3-(4-methoxyphenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5k)
(E)-3-(4-aminophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5l)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (6a)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4-dichlorophenyl)acrylamide (6b)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-fluorophenyl)acrylamide (6c)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,5-difluorophenyl)acrylamide (6d)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(2,5-dimethoxyphenyl)acrylamide (6e)
(E)-3-(4-chlorophenyl)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (6f)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (6g)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3-hydroxyphenyl)acrylamide (6h)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (6i)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (6j)
(E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-methoxyphen

Assignees

• Council Scient Ind Res

Inventors

• Kamal Ahmed
• Manda Sathish
• Narayana Nagesh
• Nagula Shankaraiah
• Sabanis Chetan Dushantrao
• Namballa Hari Krishna

Classifications

• C07D471/04 Primary

  Ortho-condensed systems · CPC title